Research on the structure and function of polysaccharides, oligosaccharides, and proteoglycans in organisms using interdisciplinary methods of organic chemistry, cell biology, molecular biology, and traditional Chinese medicine, with a focus on drug development for major diseases.
Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation, Pan, Haoyu, Chen, Xia, Wang, PeiPei, Peng, Junfeng, Li, Judong, Ding, Kan, 2023
Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing, Jiang, Lan, Zhang, Tianji, Lu, Hongzhong, Li, Saijuan, Lv, Kangjie, Tuffour, Alex, Zhang, Lixin, Ding, Kan, Li, JinPing, Li, Hongmei, Liu, Xueting, 2023
A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes, Saijuan Li, Tingting Li, Binqiang Wang, Chang Wen, Meixia Li, Kan Ding, 2023
LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin, Sun, Chuanxin, Chen, Xia, Yang, Shangpo, Jin, Can, Ding, Kan, Chen, Chang, 2023
A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling, Liao, Wenfeng, Hu, Xiaodong, Du, Zhenyun, Wang, Peipei, Ding, Kan, 2022
A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of A beta(42), Li, Saijuan, Jin, Can, Gao, Pengcheng, Zhou, Wanqi, Xiao, Rongrong, Zhang, Zhenqiang, Liao, Wenfeng, Ding, Kan, 2022
Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius, Hu, Chaoyu, Wu, Shengjie, He, Fei, Cai, Deqin, Xu, Zhuojia, Ma, Wenjing, Liu, Yating, Wei, Bangguo, Li, Tiehai, Ding, Kan, 2022
Evaluation of the predominant bacteria and proinflammatory cytokine expressions in odontogenic cysts, Li Yan, Yang Qingran, Yang Chi, Ding Kan, Xu Guangzhou, 2022
Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice, Li, Bingbing, Hong, Ying, Gu, Yu, Ye, Shengjie, Hu, Kaili, Yao, Jian, Ding, Kan, Zhao, Aihua, Jia, Wei, Li, Houkai, 2022
Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs, Huang, Lulin, Zeng, Hui, Jin, Can, Ma, Xiaonan, Zhang, Yiwen, Huang, Chunfan, Du, Zhenyun, Ding, Kan, 2022
Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection, Zhang, Shihai, Pei, Rongjuan, Li, Meixia, Su, Haixia, Sun, Hao, Ding, Yaqi, Su, Minbo, Huang, Chunfan, Chen, Xia, Du, Zhenyun, Jin, Can, Zang, Yi, Li, Jia, Xu, Yechun, Chen, Xinwen, Zhang, Bo, Ding, Kan, 2022
A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice, Pan, HaoYu, Zhang, ChunQian, Zhang, XiuQi, Zeng, Hui, Dong, ChunHong, Chen, Xia, Ding, Kan, 2022
中药多糖抗病毒机制研究进展, 卞娅, 葛广波, 丁侃, 2021
Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism, Guo, Ciliang, Wang, Yeqing, Zhang, Shihai, Zhang, Xiuqi, Du, Zhenyun, Li, Meixia, Ding, Kan, 2021
中药多糖质量控制体系初探, 王莹, 金红宇, 丁侃, 马双成, 2021
Recent progress on discovery and research of aldoxime dehydratases, Ke Chen, Zhongqiang Wang, Kan Ding, Yongzheng Chen, Yasuhisa Asano, 2021
Nostoc sphaeroids Kütz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice, Meixia Li, Ciliang Guo, Yeqing Wang, Zhenyun Du, Sheng Chen, Yulan Wang, Kan Ding, 2020
Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway, Tao, Hong, Chen, Xia, Du, Zhenyun, Ding, Kan, 2020
The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus, Wang, Yeqing, Shao, Saicong, Guo, Ciliang, Zhang, Shihai, Li, Meixia, Ding, Kan, 2020
A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy, Bian, Youcheng, Zeng, Hui, Tao, Hong, Huang, Lulin, Du, Zhenyun, Wang, Jiao, Ding, Kan, 2020
The impact of structural modification of sulfated polysaccharides on bone morphogenic protein 2 and inhibition of endothelial cell angiogenesis, Wang, Ying, Xiao, Fei, Jin, Can, Wang, Wucheng, Chen, Xia, Liu, Qin, Ding, Kan, 2020
Structural elucidation of a pectin from roots of Polygala tenuifolia and its neuritogenesis inducing activity in PC12 cells, Zeng, Hui, Huang, Lulin, Tao, Hong, Zhang, Yiwen, Ding, Kan, 2020
A novel pectin from Polygala tenuifolia blocks A beta(42) aggregation and production by enhancing insulin-degradation enzyme and neprilysin, Zeng, Hui, Li, Piaopiao, Zhou, Lishuang, Ding, Kan, 2020
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling, Li XueYing, Tao Hong, Jin Can, Du ZhenYun, Liao WenFeng, Tang QingJiu, Ding Kan, 2020
A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species, Yue Han, Zeng Hui, Ding Kan, 2020
A novel pectin from Polygala tenuifolia blocks Aβ42 aggregation and production by enhancing insulin-degradation enzyme and neprilysin, Hui Zeng, Piaopiao Li, Lishuang Zhou, Kan Ding, 2020
Intestinal microbes derived butyrate is related to the immunomodulatory activities of Dendrobium officinale polysaccharide, Li, Meixia, Yue, Han, Wang, Yeqing, Guo, Ciliang, Du, Zhenyun, Jin, Can, Ding, Kan, 2020
Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice, Li, Meixia, Guo, Ciliang, Wang, Yeqing, Du, Zhenyun, Chen, Sheng, Wang, Yulan, Ding, Kan, 2020
Characterization of anti-BCG benzalphaanthraquinones and new siderophores from a *** desert-isolated rare actinomycete Nocardia sp. XJ31, Zhang, Li, Zhang, Jingyu, Ren, Biao, Lu, Wanying, Hou, Chengjian, Wang, Jian, Ma, Xiaolong, Ma, Rong, Liu, Mei, Liu, Zhiheng, Li, JinPing, Ding, Kan, Dai, Huanqin, Zhang, Lixin, Liu, Xueting, 2020
Isolation and structure characterization of a polysaccharide from Crataegus pinnatifida and its bioactivity on gut microbiota, Guo, Ciliang, Zhang, Shihai, Wang, Yeqing, Li, Meixia, Ding, Kan, 2020
Galectin3 INHIBITOR X2 ALLEVIATES LIVER FIBROSIS VIA SURPPRESSION OF INFLAMMATION AND HEPATIC STELLATE CELLS ACTIVATION, Zang, Yi, Ding, Kan, Wang, Guanzhen, 2019
Structural characterization of a galactan from Dioscorea opposita Thunb. and its bioactivity on selected Bacteroides strains from human gut microbiota, Zhang, ChunQian, Chen, Xia, Ding, Kan, 2019
Structural elucidation of a glucan from Crataegus pinnatifida and its bioactivity on intestinal bacteria strains, Zhang, Shihai, Zhang, Chunqian, Li, Meixia, Chen, Xia, Ding, Kan, 2019
Sulfated polysaccharide JCS1S2 inhibits angiogenesis via
Keywords
PolysaccharidesOligosaccharidesProteoglycansOrganic ChemistryCell BiologyMolecular BiologyTraditional Chinese MedicineDrug DevelopmentMajor DiseasesInterdisciplinary Research
