1989-01--1991-12 Ph.D.: Shanghai Medical University
1983-01--1985-12 Master's: Jiangxi Medical College
1978-01--1982-12 Bachelor's: Jiangxi Medical College
2004-01~2023-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
1999-11~2003-12 - Institute of Neuroscience, Chinese Academy of Sciences - Researcher, Group Leader
1997-07~1999-11 - Shanghai Brain Research Institute, Chinese Academy of Sciences - Researcher, Group Leader
1994-07~1997-06 - Shanghai Brain Research Institute, Chinese Academy of Sciences - Associate Researcher, Group Leader
1992-01~1994-07 - Shanghai Brain Research Institute, Chinese Academy of Sciences - Postdoctoral Researcher
1986-01~1988-12 - Department of Anatomy, Jiangxi Medical College - Assistant Lecturer, Lecturer
Research
Neuropharmacology
Paeoniflorin Ameliorates Ischemic Neuronal Damage in vitro via Adenosine A1 Receptor-Mediated Transactivation of the Epidermal Growth Factor Receptor., Acta Pharmacology Sinica, 2015
Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
Connexin 43 stabilizes astrocytes in a stroke-like milier to faclitate neuronal recovery., Acta Pharmacology Sinica, 2015
Modulation of A 2a receptor antagonist on D 2 receptor internalization and ERK phosphorylation, ACTA PHARMACOLOGICA SINICA, 2013
Transferrin-Modified cRGDfK-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy, MOLECULAR PHARMACEUTICS, 2012
Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation, JOURNAL OF CONTROLLED RELEASE, 2012
LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression, ACTA PHARMACOLOGICA SINICA, 2012
Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells, BRITISH JOURNAL OF PHARMACOLOGY, 2011
Micelle-Based Brain-Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011
Poly(epsilon-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation, PHARMACEUTICAL RESEARCH, 2010
Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model., J Neurol Sci., 2009
Adenosine A1 receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro, 中国药理学报：英文版, 2009
AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by ��� Aminoimidazole -4- carboxamide -1-_-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D., J Biol Chem., 2009
Low temperature induced de-differentiation of astrocytes, JOURNAL OF CELLULAR BIOCHEMISTRY, 2006
Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats, JOURNAL OF CELLULAR PHYSIOLOGY, 2006
NT3 inhibits FGF2-induced neural progenitor cell proliferation via the PI3K/GSK3 pathway, JOURNAL OF NEUROCHEMISTRY, 2005
Cyclic A SCIMP Controls BDNF-induced TrkB Phosphorylation and Dendritic Spine Formation in Mature Hippocampal Neurons., Nature Neuroscience, 2005
Implication of c-secretase in neuregulin-induced maturation of oligodendrocytes, Biochem Biophys Res Commun, 2004
Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004
Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion, FEBS LETTERS, 2004
Erk1/2 but not PI3K pathway is required for neurotrophin 3-induced oligodendrocyte differentiation of post-natal neural stem cells, JOURNAL OF NEUROCHEMISTRY, 2004
Calcium signaling in Slit-dependent regulation of neuron migration., PN AS, 2004
Area of Focus
Peptides | Drug Discovery | Pharmacology | Drug Delivery | Clinical Medication | Precision Medicine | Therapeutics | Pharmaceutical Research | Clinical Trials | Drug Development
