Areas of Focus
- 神经药理学
Work Experience
- 2004-01~2023-08 - 中国科学院上海药物研究所 - 研究员，课题组长
- 1999-11~2003-12 - 中国科学院神经科学研究所 - 研究员，课题组长
- 1997-07~1999-11 - 中国科学院上海脑研究所 - 研究员，课题组长
- 1994-07~1997-06 - 中国科学院上海脑研究所 - 副研究员，课题组长
- 1992-01~1994-07 - 中国科学院上海脑研究所 - 博士后
- 1986-01~1988-12 - 江西医学院解剖教研室 - 助教、讲师
Academic Background & Achievements
- 1989-01--1991-12 博士: 上海医科大学
- 1983-01--1985-12 硕士: 江西医学院
- 1978-01--1982-12 学士: 江西医学院
Publications
- Paeoniflorin Ameliorates Ischemic Neuronal Damage in vitro via Adenosine A1 Receptor-Mediated Transactivation of the Epidermal Growth Factor Receptor., Acta Pharmacology Sinica, 2015
- Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
- Connexin 43 stabilizes astrocytes in a stroke-like milier to faclitate neuronal recovery., Acta Pharmacology Sinica, 2015
- Modulation of A 2a receptor antagonist on D 2 receptor internalization and ERK phosphorylation, ACTA PHARMACOLOGICA SINICA, 2013
- Transferrin-Modified cRGDfK-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy, MOLECULAR PHARMACEUTICS, 2012
- Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation, JOURNAL OF CONTROLLED RELEASE, 2012
- LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression, ACTA PHARMACOLOGICA SINICA, 2012
- Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells, BRITISH JOURNAL OF PHARMACOLOGY, 2011
- Micelle-Based Brain-Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011
- Poly(epsilon-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation, PHARMACEUTICAL RESEARCH, 2010
- Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model., J Neurol Sci., 2009
- Adenosine A1 receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro, 中国药理学报：英文版, 2009
- AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by ��� Aminoimidazole -4- carboxamide -1-_-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D., J Biol Chem., 2009
- Low temperature induced de-differentiation of astrocytes, JOURNAL OF CELLULAR BIOCHEMISTRY, 2006
- Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats, JOURNAL OF CELLULAR PHYSIOLOGY, 2006
- NT3 inhibits FGF2-induced neural progenitor cell proliferation via the PI3K/GSK3 pathway, JOURNAL OF NEUROCHEMISTRY, 2005
- Cyclic A SCIMP Controls BDNF-induced TrkB Phosphorylation and Dendritic Spine Formation in Mature Hippocampal Neurons., Nature Neuroscience, 2005
- Implication of c-secretase in neuregulin-induced maturation of oligodendrocytes, Biochem Biophys Res Commun, 2004
- Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004
- Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion, FEBS LETTERS, 2004
- Erk1/2 but not PI3K pathway is required for neurotrophin 3-induced oligodendrocyte differentiation of post-natal neural stem cells, JOURNAL OF NEUROCHEMISTRY, 2004
