Professor | Wei Huang | Asia Growth Partners

Name	Wei Huang
Contact Information	huangwei@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Wei Huang

Contact Information

huangwei@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Areas of Focus	Drug Synthesis Chemistry
Publications	Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance, Liu, Bo, Yu, Xueni, Liu, Liping, Wang, Lei, Wang, Jie, Huang, Qianqian, Xu, Zhongliang, Luo, Cheng, Lou, Liguang, Huang, Wei, Yang, Weibo, 2023 Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C–H activation: Macrocyclic oxime inhibitor of influenza H1N1, Hao Wang, Zhongyu Li, Xiangyang Chen, Jonathan J Wong, Tongyu Bi, Xiankun Tong, Zhongliang Xu, Mingyue Zhen, Yunhui Wan, Li Tang, Bo Liu, Xinlei Zong, Dandan Xu, Jianping Zuo, Li Yang, Wei Huang, Kendall N Houk, Weibo Yang, 2023 Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N ‐Glycan Library for Functional Glycomics, Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li, 2023 A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria, Dongliang Guan, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Yue Yu, Xinxin Feng, Lefu Lan, Wei Huang, 2023 Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates, Shi, Wei, Zhang, Jianxin, Liu, Liya, Li, Wanzhen, Liu, Zhi, Ren, Anni, Wang, Jie, Tang, Caihong, Yang, Yang, Xu, Dandan, Huang, Qianqian, Wang, Yongqin, Luo, Caili, Huang, Wei, Tang, Feng, 2022 Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization, Zou, Xiangman, Liu, Zhi, Liu, Liya, Shi, Wei, Li, Wanzhen, Guo, Zifen, Tang, Feng, Huang, Wei, 2022 CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, Long, Yiru, Sun, Jianhua, Song, TianZhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, HongYi, Long, XinYan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, YongTang, Jin, Guangyi, Gong, Likun, 2022 A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly, Zeng, Yue, Shi, Wei, Dong, Qian, Li, Wanzhen, Zhang, Jianxin, Ren, Xuelian, Tang, Caihong, Liu, Bo, Song, Yuanli, Wu, Yali, Diao, Xingxing, Zhou, Hu, Huang, He, Tang, Feng, Huang, Wei, 2022 Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a 'Derivatization-for-Sensitization' Approach, Lei, E, Tao, Huanyu, Jiao, Shang, Yang, Anming, Zhou, Yu, Wang, Min, Wen, Kang, Wang, Yi, Chen, Zhiyong, Chen, Xianhui, Song, Junfeng, Zhou, Cailing, Huang, Wei, Xu, Lili, Guan, Dongliang, Tan, Cuiyan, Liu, Haoran, Cai, Qingyun, Zhou, Kai, Modica, Justin, Huang, ShengYou, Huang, Wei, Feng, Xinxin, 2022 Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis, Chen, Yao, Tang, Feng, Qin, Hongqiang, Yue, Xuyang, Nie, Yongzhan, Huang, Wei, Ye, Mingliang, 2022 Recent advances in synthetic glycoengineering for biological applications, Zeng, Yue, Tang, Feng, Shi, Wei, Dong, Qian, Huang, Wei, 2022 One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates, Shi, Wei, Li, Wanzhen, Zhang, Jianxin, Li, Tiehai, Song, Yakai, Zeng, Yue, Dong, Qian, Lin, Zeng, Gong, Likun, Fan, Shuquan, Tang, Feng, Huang, Wei, 2022 An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids, Li, Jian, Zhu, Yue, Liu, Bo, Tang, Feng, Zheng, Xing, Huang, Wei, 2021 Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates, Shi, Weiwei, Chen, Feifei, Zou, Xiangman, Jiao, Shang, Wang, Siqi, Hu, Yu, Lan, Lefu, Tang, Feng, Huang, Wei, 2021 A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies, Song, Yakai, Deng, Xiaojie, Shi, Wei, Tang, Feng, Huang, Wei, Gong, Likun, Qin, Qiuping, 2021 An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer, Pan, Deng, Tang, Yubo, Tong, Jiao, Xie, Chengmei, Chen, Jiaxi, Feng, Chunchao, Hwu, Patrick, Huang, Wei, Zhou, Dapeng, 2020 Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation, Lu, Dan, Yin, Hongli, Wang, Siyao, Tang, Feng, Huang, Wei, Wang, Ping, 2020 Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp., Ming Li, Yaqiang Bai, Jiaorui Zhou, Wei Huang, Jingyu Yan, Jia Tao, Qingjie Fan, Yang Liu, Di Mei, Qiulong Yan, Jieli Yuan, Patrice Malard, Zhongfu Wang, Jianguo Gu, Naoyuki Tanigchi, Wenzhe Li, 2019 One-step immobilization and purification of genetic engineering CBD fusion EndoS on cellulose for antibodies Fc-glycan remodeling, Zhao, Kai, Tang, Feng, Shi, Wei, Hong, Haofei, Zhou, Zhifang, Huang, Wei, Wu, Zhimeng, 2019 蛋黄及其提取物中唾液酸糖肽的分离与测定, 李名洁, 唐峰, 郭伟来, 徐莉英, 黄蔚, 2018 Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy, Zhou, Dapeng, Xu, Lan, Huang, Wei, Tonn, Torsten, 2018 On-resin peptide ligation via C-terminus benzyl ester, Zhou, Bin, Faridoon, Tian, Xiaobo, Li, Jian, Guan, Dongliang, Zheng, Xing, Guo, Yu, Huang, Wei, 2018 Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities, Yang, Liyun, Liu, Xiaofang, Yang, Yang, Yang, Linlin, Liu, Kaiwen, Tang, Yubo, Zhang, Min, Tan, Minjia, Cheng, Shanmei, Xu, Yechun, Yang, Huaiyu, Liu, Zhijie, Song, Gaojie, Huang, Wei, 2017 Asp side-chain benzyl ester as a multi-functionalization precursor for synthesis of branched and cyclic RGD peptides, Huang Yu, 2017 N-glycosylation of the beta(2) adrenergic receptor regulates receptor function by modulating dimerization, Li, Xiaona, Zhou, Mang, Huang, Wei, Yang, Huaiyu, 2017 特拉万星合成工艺研究, 熊伦, 管栋梁, 李剑, 黄蔚, 2017 Glycoengineering and glycosite-specific labeling of serum IgGs from various species, Guo, Weilai, Tang, Feng, Qin, Ken, Zhou, Mang, Le, Zhiping, Huang, Wei, 2017 Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat, Peng, Huige, Chen, Binfan, Huang, Wei, Tang, Yubo, Jiang, Yifan, Zhang, Wenyuan, Huang, Yongzhuo, 2017 A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy, Pan, Zhenzhen, Kang, Xuejia, Zeng, Yuaner, Zhang, Wenyuan, Peng, Huige, Wang, Jinyu, Huang, Wei, Wang, Huiyuan, Shen, Youqing, Huang, Yongzhuo, 2017 eprogramming tumor-associated macrophages to reverse EGFRT790M resistance by dual-targeting codelivery of gefitinib/vorinostat., Huang Yu, 2017 Glycoconjugate probes containing a core-fucosylated N-glycan trisaccharide for fucose lectin identification and purification, Cai, Deqin, Xun, Chaochao, Tang, Feng, Tian, Xiaobo, Yang, Liyun, Ding, Kan, Li, Wenzhe, Le, Zhiping, Huang, Wei, 2017 Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control, Yubo Tang, Feng Tang, Yang Yang, Lei Zhao, Hu Zhou, Jinhua Dong, Wei Huang, 2017 Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates (gsADCs), Huang Yu, 2017 Regioselective protection of xylose for efficient synthesis of arabino-alpha-1,3-xylosides, Cai, Deqin, Guan, Dongliang, Ding, Kan, Huang, Wei, 2017 Optimal peptide hydrazide ligation with C-terminus Asp, Asn, and Gln hydrazides, Tian, Xiaobo, Li, Jie, Huang, Wei, 2016 Molecular basis of antibody binding to mucin glycopeptides in lung cancer, Qu, Jin, Yu

Areas of Focus

Drug Synthesis Chemistry

Publications

Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance, Liu, Bo, Yu, Xueni, Liu, Liping, Wang, Lei, Wang, Jie, Huang, Qianqian, Xu, Zhongliang, Luo, Cheng, Lou, Liguang, Huang, Wei, Yang, Weibo, 2023
Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C–H activation: Macrocyclic oxime inhibitor of influenza H1N1, Hao Wang, Zhongyu Li, Xiangyang Chen, Jonathan J Wong, Tongyu Bi, Xiankun Tong, Zhongliang Xu, Mingyue Zhen, Yunhui Wan, Li Tang, Bo Liu, Xinlei Zong, Dandan Xu, Jianping Zuo, Li Yang, Wei Huang, Kendall N Houk, Weibo Yang, 2023
Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N ‐Glycan Library for Functional Glycomics, Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li, 2023
A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria, Dongliang Guan, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Yue Yu, Xinxin Feng, Lefu Lan, Wei Huang, 2023
Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates, Shi, Wei, Zhang, Jianxin, Liu, Liya, Li, Wanzhen, Liu, Zhi, Ren, Anni, Wang, Jie, Tang, Caihong, Yang, Yang, Xu, Dandan, Huang, Qianqian, Wang, Yongqin, Luo, Caili, Huang, Wei, Tang, Feng, 2022
Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization, Zou, Xiangman, Liu, Zhi, Liu, Liya, Shi, Wei, Li, Wanzhen, Guo, Zifen, Tang, Feng, Huang, Wei, 2022
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, Long, Yiru, Sun, Jianhua, Song, TianZhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, HongYi, Long, XinYan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, YongTang, Jin, Guangyi, Gong, Likun, 2022
A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly, Zeng, Yue, Shi, Wei, Dong, Qian, Li, Wanzhen, Zhang, Jianxin, Ren, Xuelian, Tang, Caihong, Liu, Bo, Song, Yuanli, Wu, Yali, Diao, Xingxing, Zhou, Hu, Huang, He, Tang, Feng, Huang, Wei, 2022
Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a 'Derivatization-for-Sensitization' Approach, Lei, E, Tao, Huanyu, Jiao, Shang, Yang, Anming, Zhou, Yu, Wang, Min, Wen, Kang, Wang, Yi, Chen, Zhiyong, Chen, Xianhui, Song, Junfeng, Zhou, Cailing, Huang, Wei, Xu, Lili, Guan, Dongliang, Tan, Cuiyan, Liu, Haoran, Cai, Qingyun, Zhou, Kai, Modica, Justin, Huang, ShengYou, Huang, Wei, Feng, Xinxin, 2022
Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis, Chen, Yao, Tang, Feng, Qin, Hongqiang, Yue, Xuyang, Nie, Yongzhan, Huang, Wei, Ye, Mingliang, 2022
Recent advances in synthetic glycoengineering for biological applications, Zeng, Yue, Tang, Feng, Shi, Wei, Dong, Qian, Huang, Wei, 2022
One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates, Shi, Wei, Li, Wanzhen, Zhang, Jianxin, Li, Tiehai, Song, Yakai, Zeng, Yue, Dong, Qian, Lin, Zeng, Gong, Likun, Fan, Shuquan, Tang, Feng, Huang, Wei, 2022
An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids, Li, Jian, Zhu, Yue, Liu, Bo, Tang, Feng, Zheng, Xing, Huang, Wei, 2021
Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates, Shi, Weiwei, Chen, Feifei, Zou, Xiangman, Jiao, Shang, Wang, Siqi, Hu, Yu, Lan, Lefu, Tang, Feng, Huang, Wei, 2021
A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies, Song, Yakai, Deng, Xiaojie, Shi, Wei, Tang, Feng, Huang, Wei, Gong, Likun, Qin, Qiuping, 2021
An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer, Pan, Deng, Tang, Yubo, Tong, Jiao, Xie, Chengmei, Chen, Jiaxi, Feng, Chunchao, Hwu, Patrick, Huang, Wei, Zhou, Dapeng, 2020
Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation, Lu, Dan, Yin, Hongli, Wang, Siyao, Tang, Feng, Huang, Wei, Wang, Ping, 2020
Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp., Ming Li, Yaqiang Bai, Jiaorui Zhou, Wei Huang, Jingyu Yan, Jia Tao, Qingjie Fan, Yang Liu, Di Mei, Qiulong Yan, Jieli Yuan, Patrice Malard, Zhongfu Wang, Jianguo Gu, Naoyuki Tanigchi, Wenzhe Li, 2019
One-step immobilization and purification of genetic engineering CBD fusion EndoS on cellulose for antibodies Fc-glycan remodeling, Zhao, Kai, Tang, Feng, Shi, Wei, Hong, Haofei, Zhou, Zhifang, Huang, Wei, Wu, Zhimeng, 2019
蛋黄及其提取物中唾液酸糖肽的分离与测定, 李名洁, 唐峰, 郭伟来, 徐莉英, 黄蔚, 2018
Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy, Zhou, Dapeng, Xu, Lan, Huang, Wei, Tonn, Torsten, 2018
On-resin peptide ligation via C-terminus benzyl ester, Zhou, Bin, Faridoon, Tian, Xiaobo, Li, Jian, Guan, Dongliang, Zheng, Xing, Guo, Yu, Huang, Wei, 2018
Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities, Yang, Liyun, Liu, Xiaofang, Yang, Yang, Yang, Linlin, Liu, Kaiwen, Tang, Yubo, Zhang, Min, Tan, Minjia, Cheng, Shanmei, Xu, Yechun, Yang, Huaiyu, Liu, Zhijie, Song, Gaojie, Huang, Wei, 2017
Asp side-chain benzyl ester as a multi-functionalization precursor for synthesis of branched and cyclic RGD peptides, Huang Yu, 2017
N-glycosylation of the beta(2) adrenergic receptor regulates receptor function by modulating dimerization, Li, Xiaona, Zhou, Mang, Huang, Wei, Yang, Huaiyu, 2017
特拉万星合成工艺研究, 熊伦, 管栋梁, 李剑, 黄蔚, 2017
Glycoengineering and glycosite-specific labeling of serum IgGs from various species, Guo, Weilai, Tang, Feng, Qin, Ken, Zhou, Mang, Le, Zhiping, Huang, Wei, 2017
Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat, Peng, Huige, Chen, Binfan, Huang, Wei, Tang, Yubo, Jiang, Yifan, Zhang, Wenyuan, Huang, Yongzhuo, 2017
A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy, Pan, Zhenzhen, Kang, Xuejia, Zeng, Yuaner, Zhang, Wenyuan, Peng, Huige, Wang, Jinyu, Huang, Wei, Wang, Huiyuan, Shen, Youqing, Huang, Yongzhuo, 2017
eprogramming tumor-associated macrophages to reverse EGFRT790M resistance by dual-targeting codelivery of gefitinib/vorinostat., Huang Yu, 2017
Glycoconjugate probes containing a core-fucosylated N-glycan trisaccharide for fucose lectin identification and purification, Cai, Deqin, Xun, Chaochao, Tang, Feng, Tian, Xiaobo, Yang, Liyun, Ding, Kan, Li, Wenzhe, Le, Zhiping, Huang, Wei, 2017
Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control, Yubo Tang, Feng Tang, Yang Yang, Lei Zhao, Hu Zhou, Jinhua Dong, Wei Huang, 2017
Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates (gsADCs), Huang Yu, 2017
Regioselective protection of xylose for efficient synthesis of arabino-alpha-1,3-xylosides, Cai, Deqin, Guan, Dongliang, Ding, Kan, Huang, Wei, 2017
Optimal peptide hydrazide ligation with C-terminus Asp, Asn, and Gln hydrazides, Tian, Xiaobo, Li, Jie, Huang, Wei, 2016
Molecular basis of antibody binding to mucin glycopeptides in lung cancer, Qu, Jin, Yu

Drug Synthesis Chemistry Pharmaceuticals Organic Chemistry Biochemistry Molecular Biology Drug Development Chemical Biology Medicinal Chemistry Synthetic Methods

Jin Tang Dong - Southern University of Science and Technology

Ning Jia - Southern University of Science and Technology

Ji Yang - Southern University of Science and Technology

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us