Professor | Wei Jiao | Asia Growth Partners

Name	Wei Jiao
Contact Information	jiaowei@cib.ac.cn
Language ability	Chinese, English
Province	Sichuan

Name

Wei Jiao

Contact Information

jiaowei@cib.ac.cn

Language ability

Chinese, English

Province

Sichuan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2002 - Bachelor's Degree in Chemistry: Inner Mongolia University 2008 - Ph.D. in Medicinal Chemistry: Chengdu Institute of Biology, Chinese Academy of Sciences 2015 - Study in Bioorganic Chemistry: École Polytechnique Fédérale de Lausanne (EPFL)
Work Experience	Current - Chengdu Institute of Biology, Chinese Academy of Sciences - Associate Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2002 - Bachelor's Degree in Chemistry: Inner Mongolia University
2008 - Ph.D. in Medicinal Chemistry: Chengdu Institute of Biology, Chinese Academy of Sciences
2015 - Study in Bioorganic Chemistry: École Polytechnique Fédérale de Lausanne (EPFL)

Work Experience

Current - Chengdu Institute of Biology, Chinese Academy of Sciences - Associate Researcher

Areas of Focus	Structure-activity relationship of natural drug active ingredients and drug delivery system construction Synthesis methodology of special nuclei of active molecules Computer-aided drug design and mechanism research
Publications	Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors., Wang, H. B., Huang, X. J., Pan, Y., Zhang, G. Q., Tang, S. L., Shao, H. W., Wei Jiao, 2024 Mechanistic understanding and the rational design of a SiO2@CD catalyst for selective protection of l-lysine., Li, Pinyi, Fu, Xue, Zhou, Qiang, Fu, Xuewen, Wang, An, Zhang, Guolin, Wei Jiao, Wang, Chun, 2023 Enantioselective Cu-Catalyzed Nucleophilic Substitutions of Polyfluoroarenes: Synthesis of Chiral Polyfluoroaryl Diarylmethanes., Lin, H. X., Huang X., Wei Jiao, Fang D. M., Wang M., Liao J., 2023 New Monoterpene Glycoside Paeoniflorin Derivatives as NO and IL-1β Inhibitors: Synthesis and Biological Evaluation., Chen, Yongjie, Zhang, Guoqing, Cao, Dongyi, Wang, Fei, Zhang, Fan, Shao, Huawu, Wei Jiao, 2023 Dess-Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide., Yang, Chunmei, Zhang, Guoqing, Tang, Senling, Pan, Yang, Shao, Huawu, Wei Jiao, 2023 Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC) Inhibitors Against Hepatocellular Carcinoma Cells., Shi Hailong, Yang Jinlian, Qiao Zenen, Lingyu Li, Liu Gang, Dai Qi, Xu Li, Wei Jiao, Zhang Guolin, Wang Fei, Lu Xiaoxia, Ma Xiaofeng, 2023 多奈哌齐和美金刚与千金子活性P-糖蛋白调控剂联用的药代动力学., 陈泳洁, 李攀, 向玲, 杨春梅, 张帆, 焦威, 2022 Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming., Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang, 2022 Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]-pyran Derivatives containing Indole catalyzed by BF3.Et2O., Zhang Guoqing, Tang Senling, Yang Chunmei, Cheng Yongjie, Xiang Ling, Shao Huawu, Ma Xiaofeng, Zhang Fan, Wei Jiao, 2022 大孔树脂串联富集沙漠肉苁蓉苯乙醇苷的工艺., 向玲, 陈一鸣, 王松涛, 陈泳洁, 李姝, 焦威, 2022 Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising alpha-Glucosidase Inhibitors., Wang, Haibo, Tang, Senling, Zhang, Guoqing, Pan, Yang, Wei Jiao, Shao, Huawu, 2022 One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction., Shen, Zhongke, Tang Qin, Wei Jiao, Shao, Huawu, Ma, Xiaofeng, 2022 A Novel Method to Construct 2-Aminobenzofurans via 4+1 Cycloaddition Reaction of In Situ Generated Ortho-Quinone Methides with Isocyanides., Lin, Huaxin, Tang, Senling, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2022 不同大孔树脂苦荞黄酮富集品中4种主要黄酮的定量检测., 李姝, 王松涛, 吴萌萌, 邵华武, 赵建, 焦威, 2021 Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated 4+1 Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents., Zhang, Xiaoke, Pan, Yang, Wang, Haibo, Liang, Chong, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2021 Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl center dot H2O., Liang, Peng, Zhao, Hang, Zhou, Tingting, Zeng, Kaiyun, Wei Jiao, Pan, Yang, Liu, Yazhou, Fang, Dongmei, Ma, Xiaofeng, Shao, Huawu, 2021 UPLC-MS/MS测定大鼠血浆中多奈哌齐和美金刚在两种活性大戟二萜类化合物作用下的含量及其在药代动力学研究中的应用., 焦威, 2020 An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes., Pan, Yang, Li, Jiangtao, Li, Zhefeng, Huang, Feng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2020 An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation., Zhang, Xiaoke, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2019 A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3)., Liang, Peng, Pan, Yang, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018 丁香的化学成分研究., 但春, 焦威, 2018 A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3)., Liang, Peng, Pan, Yang, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018 Oxadiazepine Synthesis by Formal 4+3 Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3., Zhang, Xiaoke, Pan, Yang, Liang, Peng, Pang, Lu, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018 Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N., Yuan, Wen, Pan, Yang, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Wei Jiao, Shao, Huawu, 2018 Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase., Igbe, Ighodaro, Shen, XiaoFei, Wei Jiao, Qiang, Zhe, Deng, Teng, Li, Sheng, Liu, WanLi, Liu, HanWei, Zhang, GuoLin, Wang, Fei, 2017 Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase., Fei Wang, 2017 An efficient method for the stereoselective synthesis of N-substituted trihydroxypiperidine derivatives promoted by p-TsOH., Yuan, Wen, Xia, Jianhui, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Wei Jiao, Shao, Huawu, 2016 不同品种苦荞中的4种活性黄酮含量., 濮生财, 鲁璐, 焦威, 邵华武, 阳小成, 2015 Zn(OTf)(2) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives., Shen, Xudong, Xia, Jianhui, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2015 Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure-Activity Relationship Studies on Euphorbia Factor L-3 Derivatives., Wei Jiao, Wan, Zhongmin, Chen, Shuang, Lu, Runhua, Chen, Xiaozhen, Fang, Dongmei, Wang, Jiufeng, Pu, Shengcai, Huang, Xin, Gao, Haixiang, Shao, Huawu, 2015 Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose., Wang, Cong, Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Wei Jiao, Shao, Huawu, 2014 减压内沸腾和响应面分析优化苦荞总黄酮提取工艺., 焦威, 万忠民, 濮生财, 焦威, 阳小成, 邵华武, 2014 Biphenyls from aerial parts of Ribes takare., Chen, XiaoZhen, Lu, ShengMing, Li, GuoYou, Wei Jiao, Huang, TianFang, Yang, Tao, Fang, DongMei, 2014 太子

Areas of Focus

Structure-activity relationship of natural drug active ingredients and drug delivery system construction
Synthesis methodology of special nuclei of active molecules
Computer-aided drug design and mechanism research

Publications

Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors., Wang, H. B., Huang, X. J., Pan, Y., Zhang, G. Q., Tang, S. L., Shao, H. W., Wei Jiao, 2024
Mechanistic understanding and the rational design of a SiO2@CD catalyst for selective protection of l-lysine., Li, Pinyi, Fu, Xue, Zhou, Qiang, Fu, Xuewen, Wang, An, Zhang, Guolin, Wei Jiao, Wang, Chun, 2023
Enantioselective Cu-Catalyzed Nucleophilic Substitutions of Polyfluoroarenes: Synthesis of Chiral Polyfluoroaryl Diarylmethanes., Lin, H. X., Huang X., Wei Jiao, Fang D. M., Wang M., Liao J., 2023
New Monoterpene Glycoside Paeoniflorin Derivatives as NO and IL-1β Inhibitors: Synthesis and Biological Evaluation., Chen, Yongjie, Zhang, Guoqing, Cao, Dongyi, Wang, Fei, Zhang, Fan, Shao, Huawu, Wei Jiao, 2023
Dess-Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide., Yang, Chunmei, Zhang, Guoqing, Tang, Senling, Pan, Yang, Shao, Huawu, Wei Jiao, 2023
Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC) Inhibitors Against Hepatocellular Carcinoma Cells., Shi Hailong, Yang Jinlian, Qiao Zenen, Lingyu Li, Liu Gang, Dai Qi, Xu Li, Wei Jiao, Zhang Guolin, Wang Fei, Lu Xiaoxia, Ma Xiaofeng, 2023
多奈哌齐和美金刚与千金子活性P-糖蛋白调控剂联用的药代动力学., 陈泳洁, 李攀, 向玲, 杨春梅, 张帆, 焦威, 2022
Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming., Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang, 2022
Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]-pyran Derivatives containing Indole catalyzed by BF3.Et2O., Zhang Guoqing, Tang Senling, Yang Chunmei, Cheng Yongjie, Xiang Ling, Shao Huawu, Ma Xiaofeng, Zhang Fan, Wei Jiao, 2022
大孔树脂串联富集沙漠肉苁蓉苯乙醇苷的工艺., 向玲, 陈一鸣, 王松涛, 陈泳洁, 李姝, 焦威, 2022
Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising alpha-Glucosidase Inhibitors., Wang, Haibo, Tang, Senling, Zhang, Guoqing, Pan, Yang, Wei Jiao, Shao, Huawu, 2022
One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction., Shen, Zhongke, Tang Qin, Wei Jiao, Shao, Huawu, Ma, Xiaofeng, 2022
A Novel Method to Construct 2-Aminobenzofurans via 4+1 Cycloaddition Reaction of In Situ Generated Ortho-Quinone Methides with Isocyanides., Lin, Huaxin, Tang, Senling, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2022
不同大孔树脂苦荞黄酮富集品中4种主要黄酮的定量检测., 李姝, 王松涛, 吴萌萌, 邵华武, 赵建, 焦威, 2021
Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated 4+1 Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents., Zhang, Xiaoke, Pan, Yang, Wang, Haibo, Liang, Chong, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2021
Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl center dot H2O., Liang, Peng, Zhao, Hang, Zhou, Tingting, Zeng, Kaiyun, Wei Jiao, Pan, Yang, Liu, Yazhou, Fang, Dongmei, Ma, Xiaofeng, Shao, Huawu, 2021
UPLC-MS/MS测定大鼠血浆中多奈哌齐和美金刚在两种活性大戟二萜类化合物作用下的含量及其在药代动力学研究中的应用., 焦威, 2020
An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes., Pan, Yang, Li, Jiangtao, Li, Zhefeng, Huang, Feng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2020
An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation., Zhang, Xiaoke, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2019
A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3)., Liang, Peng, Pan, Yang, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018
丁香的化学成分研究., 但春, 焦威, 2018
A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3)., Liang, Peng, Pan, Yang, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018
Oxadiazepine Synthesis by Formal 4+3 Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3., Zhang, Xiaoke, Pan, Yang, Liang, Peng, Pang, Lu, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2018
Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N., Yuan, Wen, Pan, Yang, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Wei Jiao, Shao, Huawu, 2018
Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase., Igbe, Ighodaro, Shen, XiaoFei, Wei Jiao, Qiang, Zhe, Deng, Teng, Li, Sheng, Liu, WanLi, Liu, HanWei, Zhang, GuoLin, Wang, Fei, 2017
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase., Fei Wang, 2017
An efficient method for the stereoselective synthesis of N-substituted trihydroxypiperidine derivatives promoted by p-TsOH., Yuan, Wen, Xia, Jianhui, Zhang, Xiaoke, Liang, Peng, Zhang, Jichao, Wei Jiao, Shao, Huawu, 2016
不同品种苦荞中的4种活性黄酮含量., 濮生财, 鲁璐, 焦威, 邵华武, 阳小成, 2015
Zn(OTf)(2) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives., Shen, Xudong, Xia, Jianhui, Liang, Peng, Ma, Xiaofeng, Wei Jiao, Shao, Huawu, 2015
Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure-Activity Relationship Studies on Euphorbia Factor L-3 Derivatives., Wei Jiao, Wan, Zhongmin, Chen, Shuang, Lu, Runhua, Chen, Xiaozhen, Fang, Dongmei, Wang, Jiufeng, Pu, Shengcai, Huang, Xin, Gao, Haixiang, Shao, Huawu, 2015
Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose., Wang, Cong, Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Wei Jiao, Shao, Huawu, 2014
减压内沸腾和响应面分析优化苦荞总黄酮提取工艺., 焦威, 万忠民, 濮生财, 焦威, 阳小成, 邵华武, 2014
Biphenyls from aerial parts of Ribes takare., Chen, XiaoZhen, Lu, ShengMing, Li, GuoYou, Wei Jiao, Huang, TianFang, Yang, Tao, Fang, DongMei, 2014
太子

Natural Drugs Active Ingredients Structure-Activity Relationship Drug Delivery Synthesis Methodology Active Molecules Computer-Aided Design Drug Design Mechanism Research Computational Chemistry

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