Areas of Focus
- Tumor Immunotherapy Research
- Humanized Mouse Research
Work Experience
- 2016-07~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
- 2012-07~2013-09 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Research Intern
Academic Background & Achievements
- 2013-09--2016-06 PhD: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- 2009-09--2012-07 Master's in Medicine: Shantou University
- 2005-09--2009-07 Bachelor's in Science: Yantai University
Publications
- CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation, 8th Author, 2019
- Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, 5th Author, 2019
- DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells, 3rd Author, 2018
- InVitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Collaborative Group Author, 2018
- Emerging role of C5a/C5aR IL-17A axis in cGVHD, Collaborative Group Author, 2018
- Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia, 3rd Author, 2018
- A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia, 5th Author, 2018
- The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells, 7th Author, 2017
- Low-dose decitabine enhances chidamide-induced apoptosis in adult acute lymphoblast leukemia, especially for p16-deleted patients through DNA damage, 4th Author, 2017
- Toll-like Receptor 2 Costimulation Potentiates the Antitumor Efficacy of CAR T Cells, 7th Author, 2017
- Anti-GPC3 CAR T cells suppress the growth of tumour cells in patient-derived xenografts of hepatocellular carcinoma, 1st Author, 2017
- Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia, 1st Author, 2017
- Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption, 4th Author, 2016
- GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways, 2nd Author, 2016
- Identification of growth factors that promote the proliferation and drug resistance of human primary acute B lymphoblastic cells, 2nd Author, 2016
- Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication, 3rd Author, 2016
- Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models, 2nd Author, 2016
- Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized, 1st Author, 2016
- CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia, 1st Author, 2016
- Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized, 1st Author, 2015
- A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor, 6th Author, 2015
- Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments, 2nd Author, 2015
- Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes, 2nd Author, 2015
- ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells, 2nd Author, 2015
- Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site, 7th Author, 2013
- Generation of RAG 1 and 2 deficient rabbits by embryo microinjection of TALENs, 5th Author, 2013
- Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes, 7th Author, 2013
- Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition, 8th Author, 2012
Awards
- 2019: Second Prize, Establishment and Application of Humanized Mouse and Its Preclinical Evaluation Platform, Provincial Level
- 2017: China Patent Excellence Award, National Level
- 2017: Guangdong Province Patent Excellence Award, Provincial Level
