2013-09--2016-06 PhD: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
2009-09--2012-07 Master's in Medicine: Shantou University
2005-09--2009-07 Bachelor's in Science: Yantai University
2016-07~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
2012-07~2013-09 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Research Intern
2019: Second Prize, Establishment and Application of Humanized Mouse and Its Preclinical Evaluation Platform, Provincial Level
2017: China Patent Excellence Award, National Level
2017: Guangdong Province Patent Excellence Award, Provincial Level
Research
Tumor Immunotherapy Research Humanized Mouse Research
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation, 8th Author, 2019
Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, 5th Author, 2019
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells, 3rd Author, 2018
InVitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Collaborative Group Author, 2018
Emerging role of C5a/C5aR IL-17A axis in cGVHD, Collaborative Group Author, 2018
Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia, 3rd Author, 2018
A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia, 5th Author, 2018
The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells, 7th Author, 2017
Low-dose decitabine enhances chidamide-induced apoptosis in adult acute lymphoblast leukemia, especially for p16-deleted patients through DNA damage, 4th Author, 2017
Toll-like Receptor 2 Costimulation Potentiates the Antitumor Efficacy of CAR T Cells, 7th Author, 2017
Anti-GPC3 CAR T cells suppress the growth of tumour cells in patient-derived xenografts of hepatocellular carcinoma, 1st Author, 2017
Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia, 1st Author, 2017
Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption, 4th Author, 2016
GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways, 2nd Author, 2016
Identification of growth factors that promote the proliferation and drug resistance of human primary acute B lymphoblastic cells, 2nd Author, 2016
Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication, 3rd Author, 2016
Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models, 2nd Author, 2016
Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized, 1st Author, 2016
CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia, 1st Author, 2016
Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized, 1st Author, 2015
A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor, 6th Author, 2015
Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments, 2nd Author, 2015
Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes, 2nd Author, 2015
ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells, 2nd Author, 2015
Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site, 7th Author, 2013
Generation of RAG 1 and 2 deficient rabbits by embryo microinjection of TALENs, 5th Author, 2013
Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes, 7th Author, 2013
Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition, 8th Author, 2012
Keywords
Car T CellsMalignant TumorsImmunotherapyPreclinical EvaluationClinical TranslationPdx ModelsHumanized Mouse ModelsLiver HumanizationTumor XenograftsImmunodeficiency
Area of Focus
Lung Cancer | Diagnosis | Treatment | Clinical Research | Immunotherapy | Tumor | Oncology | Therapy | Clinical Trials | Cancer Research | Clinical Translation | Cancer Treatment | Research | Immune Response
