1999-09--2002-06 Master's: Central China Normal University
1995-09--1999-06 Bachelor's: Wuhan Institute of Technology
2008-07~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Group Leader
2006-03~2008-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
2002-09~2005-12 - Zhejiang University - PhD
1999-09~2002-06 - Central China Normal University - Master's
1995-09~1999-06 - Wuhan Institute of Technology - Bachelor's
Outstanding Communist Party Member of Shanghai Branch, Chinese Academy of Sciences (2022): Other
May Fourth Youth Commando of Shanghai Branch, Chinese Academy of Sciences (2021): Municipal Level
Commemorative Medal for Fighting COVID-19, Shanghai Institute of Materia Medica (2020): Institute Level
Research
Small Molecule Structure-Activity Relationship Research Modification of Natural Product Structures Drug Synthesis Process Research
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, 5th Author, 2023
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir, 1st Author, 2023
Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL pro inhibitors against SARS-CoV-2, 8th Author, 2023
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety, 9th Author, 2023
Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2, 8th Author, 2023
Synthesis and biological evaluation of artemisinin derivatives as potential MS agents, 11th Author, 2022
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor, 14th Author, 2022
Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis, 2nd Author, 2022
9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation, 11th Author, 2021
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 13th Author, 2021
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, 13th Author, 2021
Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor, 11th Author, 2020
The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis, 3rd Author, 2020
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives, 3rd Author, 2020
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning, 2nd Author, 2020
Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts, 6th Author, 2019
Metal-free quinolylation of the primary amino groups of amino acid derivatives and peptides with dihydrooxazolo3,2-aquinoliniums, 10th Author, 2019
Nature brings new avenues to the therapy of central nervous system diseases--an overview of possible treatments derived from natural products, 3rd Author, 2019
Pharmacokinetics-driven optimization of 4(3h)-pyrimidinones as phosphodiesterase type 5 inhibitors leading to tpn171, a clinical candidate for the treatment of pulmonary arterial hypertension, 2nd Author, 2019
Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors, 3rd Author, 2019
Continuation of structure-activity relationship study of novel benzamide derivatives as potential antipsychotics, 6th Author, 2019
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry, 4th Author, 2019
Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents, 5th Author, 2019
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs, 7th Author, 2018
Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect, 7th Author, 2018
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics, 7th Author, 2017
Synthesis of Impurities of Pramipexole Dihydrochloride, 11th Author, 2016
Research progress of antipsychotics, 5th Author, 2016
Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics, 2nd Author, 2016
Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review, 3rd Author, 2016
Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride, 11th Author, 2015
Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, 11th Author, 2015
A neighboring group participation strategy: facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-D-arabino-gamma-lactone, 6th Author, 2015
Design, Synthesis, and Pharmacological Evaluationof Fused β-Homophenylalanine Derivatives as Potent DPP-4Inhibitors, 9th Author, 2015
New Synthesis of N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide, 11th Author, 2015
Design, Synthesis, and Pharmacological Evaluation of Fused beta-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors, 11th Author, 2015
An Improved Synthesis of 4-(1-Piperazinyl)benzobthiophene Dihydrochloride, 11th Author, 2015
Improvement of the Process for Sodium Gslycocholate, 3rd Author, 2014
Area of Focus
Drug Synthesis | Organic Chemistry | Pharmaceutical Chemistry | Chemical Synthesis | Medicinal Chemistry | Drug Development | Synthetic Methods | Chemical Reactions | Molecular Design | Bioorganic Chemistry
