Areas of Focus
- Drug Synthesis Chemistry
Work Experience
- 2000-05 to 2016-06 - Shanghai Institute of Materia Medica - Researcher
- 1997-08 to 2000-05 - Georgetown University Medical Center - Postdoctoral
- 2014-08-31 to 2016-06-17 - East China Normal University - Adjunct Professor
- 2011-05-01 to 2016-06-17 - Shanghai Pharmaceutical Association - Director
- 2005-07-01 to 2016-06-17 - Drug Discovery Today - Advisory Editorial Board
- 2004-09-01 to 2016-06-17 - Huazhong University of Science and Technology - Adjunct Professor
Academic Background & Achievements
- 1994-09 to 1997-06 PhD: Shanghai Institute of Organic Chemistry
- 1991-09 to 1994-06 Master's: Lanzhou University
- 1987-09 to 1991-06 Bachelor's: Lanzhou University
Publications
- Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 11th Author, 2016
- Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 5th Author, 2016
- Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 11th Author, 2016
- Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 8th Author, 2015
- P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 10th Author, 2015
- Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 13th Author, 2015
- Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 11th Author, 2015
- Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 7th Author, 2014
- Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 7th Author, 2014
- Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 6th Author, 2014
- Total Synthesis of Aphadilactones A-D, 4th Author, 2014
- Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 11th Author, 2014
- Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 8th Author, 2014
- Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 7th Author, 2014
- Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 11th Author, 2014
- Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 9th Author, 2014
Awards
- Pudong New Area Science and Technology Progress Award (2015): First Prize
- First Batch of Leading Talents in Scientific and Technological Innovation of the 'Ten Thousand Talents Program' (2013): National Level
- National 'New Century Talents Project' (2009): National Level
- Shanghai Leading Talent Award (2007): Provincial Level
- Shanghai Science and Education Party Committee System Youth Science and Technology Innovation Talent Award (2006): Provincial Level
- 8th Wu Jieping Medical Research Award - Paul Janssen Pharmaceutical Research (2004): Second Prize
- Establishment of National New Drug Screening Center and Research and Application of High-Throughput Screening Technology (2003): Second Prize, National Level
- Research and Application of Modern New Drug Screening System and High-Throughput Screening Technology (2002): First Prize, Provincial Level
