Professor | Nan Fajun | Asia Growth Partners

Name	Nan Fajun
Contact Information	fjnan@mail.shcnc.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Nan Fajun

Contact Information

fjnan@mail.shcnc.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1994-09 to 1997-06 PhD: Shanghai Institute of Organic Chemistry 1991-09 to 1994-06 Master's: Lanzhou University 1987-09 to 1991-06 Bachelor's: Lanzhou University
Work Experience	2000-05 to 2016-06 - Shanghai Institute of Materia Medica - Researcher 1997-08 to 2000-05 - Georgetown University Medical Center - Postdoctoral 2014-08-31 to 2016-06-17 - East China Normal University - Adjunct Professor 2011-05-01 to 2016-06-17 - Shanghai Pharmaceutical Association - Director 2005-07-01 to 2016-06-17 - Drug Discovery Today - Advisory Editorial Board 2004-09-01 to 2016-06-17 - Huazhong University of Science and Technology - Adjunct Professor
Awards	Pudong New Area Science and Technology Progress Award (2015): First Prize First Batch of Leading Talents in Scientific and Technological Innovation of the 'Ten Thousand Talents Program' (2013): National Level National 'New Century Talents Project' (2009): National Level Shanghai Leading Talent Award (2007): Provincial Level Shanghai Science and Education Party Committee System Youth Science and Technology Innovation Talent Award (2006): Provincial Level 8th Wu Jieping Medical Research Award - Paul Janssen Pharmaceutical Research (2004): Second Prize Establishment of National New Drug Screening Center and Research and Application of High-Throughput Screening Technology (2003): Second Prize, National Level Research and Application of Modern New Drug Screening System and High-Throughput Screening Technology (2002): First Prize, Provincial Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1994-09 to 1997-06 PhD: Shanghai Institute of Organic Chemistry
1991-09 to 1994-06 Master's: Lanzhou University
1987-09 to 1991-06 Bachelor's: Lanzhou University

Work Experience

2000-05 to 2016-06 - Shanghai Institute of Materia Medica - Researcher
1997-08 to 2000-05 - Georgetown University Medical Center - Postdoctoral
2014-08-31 to 2016-06-17 - East China Normal University - Adjunct Professor
2011-05-01 to 2016-06-17 - Shanghai Pharmaceutical Association - Director
2005-07-01 to 2016-06-17 - Drug Discovery Today - Advisory Editorial Board
2004-09-01 to 2016-06-17 - Huazhong University of Science and Technology - Adjunct Professor

Awards

Pudong New Area Science and Technology Progress Award (2015): First Prize
First Batch of Leading Talents in Scientific and Technological Innovation of the 'Ten Thousand Talents Program' (2013): National Level
National 'New Century Talents Project' (2009): National Level
Shanghai Leading Talent Award (2007): Provincial Level
Shanghai Science and Education Party Committee System Youth Science and Technology Innovation Talent Award (2006): Provincial Level
8th Wu Jieping Medical Research Award - Paul Janssen Pharmaceutical Research (2004): Second Prize
Establishment of National New Drug Screening Center and Research and Application of High-Throughput Screening Technology (2003): Second Prize, National Level
Research and Application of Modern New Drug Screening System and High-Throughput Screening Technology (2002): First Prize, Provincial Level

Areas of Focus	Drug Synthesis Chemistry
Publications	Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 11th Author, 2016 Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 5th Author, 2016 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 11th Author, 2016 Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 8th Author, 2015 P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 10th Author, 2015 Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 13th Author, 2015 Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 11th Author, 2015 Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 7th Author, 2014 Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 7th Author, 2014 Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 6th Author, 2014 Total Synthesis of Aphadilactones A-D, 4th Author, 2014 Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 11th Author, 2014 Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 8th Author, 2014 Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 7th Author, 2014 Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 11th Author, 2014 Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 9th Author, 2014

Areas of Focus

Drug Synthesis Chemistry

Publications

Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 11th Author, 2016
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 5th Author, 2016
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 11th Author, 2016
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 8th Author, 2015
P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 10th Author, 2015
Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 13th Author, 2015
Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 11th Author, 2015
Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 7th Author, 2014
Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 7th Author, 2014
Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 6th Author, 2014
Total Synthesis of Aphadilactones A-D, 4th Author, 2014
Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 11th Author, 2014
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 8th Author, 2014
Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 7th Author, 2014
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 11th Author, 2014
Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 9th Author, 2014

Drug Synthesis Organic Chemistry Pharmaceutical Chemistry Chemical Synthesis Medicinal Chemistry Drug Development Synthetic Methods Chemical Reactions Molecular Design Bioorganic Chemistry

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