Professor | 南发俊 | 数字化转型顾问

Name	南发俊
Contact Information	fjnan@mail.shcnc.ac.cn
Language ability	中文, 英语
Province	上海

Name

南发俊

Contact Information

fjnan@mail.shcnc.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1994-09 至 1997-06 博士: 上海有机化学研究所 1991-09 至 1994-06 硕士: 兰州大学 1987-09 至 1991-06 学士: 兰州大学
Work Experience	2000-05 至 2016-06 - 上海药物研究所 - 研究员 1997-08 至 2000-05 - 乔治城大学医学中心 - 博士后 2014-08-31 至 2016-06-17 - 华东师范大学 - 兼职教授 2011-05-01 至 2016-06-17 - 上海市药学会 - 理事 2005-07-01 至 2016-06-17 - Drug Discovery Today - 咨询编辑委员会 2004-09-01 至 2016-06-17 - 华中科技大学 - 兼职教授
Awards	浦东新区科技进步一等奖 (2015): 一等奖 “万人计划”第一批科技创新领军人才 (2013): 国家级国家级“新世纪百千万人才工程” (2009): 国家级上海市领军人才奖 (2007): 省级上海市科教党委系统青年科技创新人才奖 (2006): 省级第八届吴阶平医学研究奖-保罗杨森药学研究 (2004): 二等奖国家新药筛选中心的建立和高通量筛选技术的研究及应用 (2003): 二等奖, 国家级现代新药筛选体系和高通量筛选技术的研究及应用 (2002): 一等奖, 省级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1994-09 至 1997-06 博士: 上海有机化学研究所
1991-09 至 1994-06 硕士: 兰州大学
1987-09 至 1991-06 学士: 兰州大学

Work Experience

2000-05 至 2016-06 - 上海药物研究所 - 研究员
1997-08 至 2000-05 - 乔治城大学医学中心 - 博士后
2014-08-31 至 2016-06-17 - 华东师范大学 - 兼职教授
2011-05-01 至 2016-06-17 - 上海市药学会 - 理事
2005-07-01 至 2016-06-17 - Drug Discovery Today - 咨询编辑委员会
2004-09-01 至 2016-06-17 - 华中科技大学 - 兼职教授

Awards

浦东新区科技进步一等奖 (2015): 一等奖
“万人计划”第一批科技创新领军人才 (2013): 国家级
国家级“新世纪百千万人才工程” (2009): 国家级
上海市领军人才奖 (2007): 省级
上海市科教党委系统青年科技创新人才奖 (2006): 省级
第八届吴阶平医学研究奖-保罗杨森药学研究 (2004): 二等奖
国家新药筛选中心的建立和高通量筛选技术的研究及应用 (2003): 二等奖, 国家级
现代新药筛选体系和高通量筛选技术的研究及应用 (2002): 一等奖, 省级

Areas of Focus	药物合成化学
Publications	Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 第11作者, 2016 Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 第5作者, 2016 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 第11作者, 2016 Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 第8作者, 2015 P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 第10作者, 2015 Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 第13作者, 2015 Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 第11作者, 2015 Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 第7作者, 2014 Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 第7作者, 2014 Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 第6作者, 2014 Total Synthesis of Aphadilactones A-D, 第4作者, 2014 Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 第11作者, 2014 Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 第8作者, 2014 Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 第7作者, 2014 Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 第11作者, 2014 Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 第9作者, 2014

Areas of Focus

药物合成化学

Publications

Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 第11作者, 2016
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 第5作者, 2016
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 第11作者, 2016
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 第8作者, 2015
P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 第10作者, 2015
Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 第13作者, 2015
Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 第11作者, 2015
Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 第7作者, 2014
Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 第7作者, 2014
Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 第6作者, 2014
Total Synthesis of Aphadilactones A-D, 第4作者, 2014
Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 第11作者, 2014
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 第8作者, 2014
Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 第7作者, 2014
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 第11作者, 2014
Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 第9作者, 2014

药物合成有机化学药物化学化学合成药物开发合成方法化学反应分子设计生物有机化学

林映甫 - 武汉大学

蒋华良 - 中国科学院大学

柳红 - 中国科学院大学

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