Areas of Focus
- 药物合成化学
Work Experience
- 2000-05 至 2016-06 - 上海药物研究所 - 研究员
- 1997-08 至 2000-05 - 乔治城大学医学中心 - 博士后
- 2014-08-31 至 2016-06-17 - 华东师范大学 - 兼职教授
- 2011-05-01 至 2016-06-17 - 上海市药学会 - 理事
- 2005-07-01 至 2016-06-17 - Drug Discovery Today - 咨询编辑委员会
- 2004-09-01 至 2016-06-17 - 华中科技大学 - 兼职教授
Academic Background & Achievements
- 1994-09 至 1997-06 博士: 上海有机化学研究所
- 1991-09 至 1994-06 硕士: 兰州大学
- 1987-09 至 1991-06 学士: 兰州大学
Publications
- Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation, 第11作者, 2016
- Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2), 第5作者, 2016
- Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, 第11作者, 2016
- Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, 第8作者, 2015
- P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, 第10作者, 2015
- Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, 第13作者, 2015
- Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis, 第11作者, 2015
- Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, 第7作者, 2014
- Design and synthesis of 3,3 '-biscoumarin-based c-Met inhibitors, 第7作者, 2014
- Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy, 第6作者, 2014
- Total Synthesis of Aphadilactones A-D, 第4作者, 2014
- Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons, 第11作者, 2014
- Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, 第8作者, 2014
- Discovery of a NegativeAllosteric Modulator of GABA B Receptors, 第7作者, 2014
- Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation, 第11作者, 2014
- Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation, 第9作者, 2014
Awards
- 浦东新区科技进步一等奖 (2015): 一等奖
- “万人计划”第一批科技创新领军人才 (2013): 国家级
- 国家级“新世纪百千万人才工程” (2009): 国家级
- 上海市领军人才奖 (2007): 省级
- 上海市科教党委系统青年科技创新人才奖 (2006): 省级
- 第八届吴阶平医学研究奖-保罗杨森药学研究 (2004): 二等奖
- 国家新药筛选中心的建立和高通量筛选技术的研究及应用 (2003): 二等奖, 国家级
- 现代新药筛选体系和高通量筛选技术的研究及应用 (2002): 一等奖, 省级
