Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM), Eur J Med Chem, 2023
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice, ACTA PHARMACOLOGICA SINICA, 2023
Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis, Journal of Medicinal Chemistry, 2023
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice, NUTRIENTS, 2022
Development and structure-activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors, NATURAL PRODUCTS AND BIOPROSPECTING, 2022
Design, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022
Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022
Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects, CHEMISTRY & BIODIVERSITY, 2021
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage, METABOLISM-CLINICAL AND EXPERIMENTAL, 2021
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Discovery of Highly Polar beta-Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2019
TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice, METABOLISM-CLINICAL AND EXPERIMENTAL, 2019
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, FRONTIERS IN PHARMACOLOGY, 2018
Structural Elucidation and Bioinspired Total Syntheses of Ascorbylated Diterpenoid Hongkonoids A-D, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018
Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017
Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN, 2017
Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata, PHYTOCHEMISTRY, 2017
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017
16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors, SCIENTIFIC REPORTS, 2016
Synthesis of hupehenols A, B, and E from protopanaxadiol, RSC ADVANCES, 2016
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, ACTA PHARMACOLOGICA SINICA, 2016
Analysis of diacylglycerols by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Double bond location and isomers separation, ANALYTICA CHIMICA ACTA, 2016
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, SCIENTIFIC REPORTS, 2016
Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists, CHEMICAL & PHARMACEUTICAL BULLETIN, 2016
Limonoids and Triterpenoids as 11 beta-HSD1 Inhibitors from Walsura robusta, JOURNAL OF NATURAL PRODUCTS, 2016
Design and Synthesis of Novel Arctigenin Analoguesfor the Amelioration of Metabolic Disorders, ACS MEDICINAL CHEMISTRY LETTERS, 2015
Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015
HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes, JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015
Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense, JOURNAL OF NATURAL PRODUCTS, 2015
AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015
Ricinodols A-G: new tetracyclic triterpenoids as 11 beta-HSD1 inhibitors from Ricinodendron heudelotii, RSC ADVANCES, 2015
Limonoids with 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum, JOURNAL OF NATURAL PRODUCTS, 2015
Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2015
Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia, ORGANIC & BIOMOLECULAR CHEMISTRY, 2014
New rearranged limonoids from Walsura cochinchinensis, RSC ADVANCES, 2014
Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014
Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity, JOURNAL OF NATURAL PRODUCTS, 2014
Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus, JOURNAL OF NATURAL PRODUCTS, 2014
SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models, ACTA PHARMACOLOGICA SINICA, 2014
4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014
Further cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca, PHYTOCHEMISTRY LETTERS, 2014
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes, BIOORGANIC MEDICINAL CHEMISTRY, 2013
11 beta-HSD1 Inhibitors from Walsura cochinchinensis
