Professor | Xingguo Liu | Asia Growth Partners

Name	Xingguo Liu
Contact Information	liu_xingguo@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Xingguo Liu

Contact Information

liu_xingguo@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2002-09--2007-01 PhD: Tsinghua University 1998-09--2002-07 Bachelor: Shandong University 2007-2010: Postdoctoral Research at Thomas Jefferson University
Work Experience	2010-present: Researcher at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences 2007-2010: Postdoctoral Researcher at Thomas Jefferson University
Awards	2016: Guangdong Province Science and Technology Innovation 'Leading Talent' 2015: First Guangdong Province Science and Technology Innovation Young Top Talent 2012: First Guangdong Province Natural Science Outstanding Youth Fund (Talent Program, 16 people) 2011: Selected for Chinese Academy of Sciences '****', received preferential support in 2012 2011: 'Young Bioenergeticist Award' from the International Biophysics Society

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2002-09--2007-01 PhD: Tsinghua University
1998-09--2002-07 Bachelor: Shandong University
2007-2010: Postdoctoral Research at Thomas Jefferson University

Work Experience

2010-present: Researcher at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
2007-2010: Postdoctoral Researcher at Thomas Jefferson University

Awards

2016: Guangdong Province Science and Technology Innovation 'Leading Talent'
2015: First Guangdong Province Science and Technology Innovation Young Top Talent
2012: First Guangdong Province Natural Science Outstanding Youth Fund (Talent Program, 16 people)
2011: Selected for Chinese Academy of Sciences '****', received preferential support in 2012
2011: 'Young Bioenergeticist Award' from the International Biophysics Society

Areas of Focus	Role of metabolic changes and mitochondria in stem cell fate regulation Role of cell signaling in stem cell fate regulation Mechanism of human mitochondrial diseases and stem cell therapy
Publications	MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Xing, Guangsuo, Liu, Zichao, Huang, Luyuan, Zhao, Danyun, Wang, Tao, Yuan, Hao, Wu, Yi, Li, Linpeng, Long, Qi, Zhou, Yanshuang, Hao, Zhihong, Liu, Yang, Lu, Jianghuan, Li, Shiting, Zhu, Jieying, Wang, Bo, Wang, Junwei, Liu, Jing, Chen, Jiekai, Pei, Duanqing, Liu, Xingguo, Chen, Keshi, 2022 Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation, Li, Wei, Long, Qi, Wu, Hao, Zhou, Yanshuang, Duan, Lifan, Yuan, Hao, Ding, Yingzhe, Huang, Yile, Wu, Yi, Huang, Jinyu, Liu, Delong, Chen, Baodan, Zhang, Jian, Qi, Juntao, Du, Shiwei, Li, Linpeng, Liu, Yang, Ruan, Zifeng, Liu, Zihuang, Liu, Zichao, Zhao, Yifan, Lu, Jianghuan, Wang, Junwei, Chan, WaiYee, Liu, Xingguo, 2022 Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms, Liu, Xingguo, 2022 Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation (vol 28, pg 900, 2021), Long, Qi, Zhou, Yanshuang, Wu, Hao, Du, Shiwei, Hu, Mingli, Qi, Juntao, Li, Wei, Guo, Jingyi, Wu, Yi, Yang, Liang, Xiang, Ge, Wang, Liang, Ye, Shouhua, Wen, Jiayuan, Mao, Heng, Wang, Junwei, Zhao, Hui, Chan, WaiYee, Liu, Jinsong, Chen, Yonglong, Li, Pilong, Liu, Xingguo, 2021 Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space, Liu, Xingguo, 2021 A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome, Guo, Jingyi, Duan, Lifan, He, Xueying, Li, Shengbiao, Wu, Yi, Xiang, Ge, Bao, Feixiang, Yang, Liang, Shi, Hongyan, Gao, Mi, Zheng, Lingjun, Hu, Huili, Liu, Xingguo, 2021 A new sight: topology-dependent mitophagy, Zhou, Yanshuang, Long, Qi, Liu, Xingguo, 2020 Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, Li, Linpeng, Chen, Keshi, Wang, Tianyu, Wu, Yi, Xing, Guangsuo, Chen, Mengqi, Hao, Zhihong, Zhang, Cheng, Zhang, Jinye, Ma, Bochao, Liu, Zihuang, Yuan, Hao, Liu, Zijian, Long, Qi, Zhou, Yanshuang, Qi, Juntao, Zhao, Danyun, Gao, Mi, Pei, Duanqing, Nie, Jinfu, Ye, Dan, Pan, Guangjin, Liu, Xingguo, 2020 Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+)redox, Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo, 2020 Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade, Liu, Xingguo, 2020 线粒体定位circRNA调控肝脏免疫代谢性炎症机制, 苏士成, 宋保亮, 陈玲玲, 刘兴国, 2020 Topology-dependent, bifurcated mitochondrial quality control under starvation, Zhou, Yanshuang, Long, Qi, Wu, Hao, Li, Wei, Qi, Juntao, Wu, Yi, Xiang, Ge, Tang, Haite, Yang, Liang, Chen, Keshi, Li, Linpeng, Bao, Feixiang, Li, Heying, Wang, Yaofeng, Li, Min, Liu, Xingguo, 2020 OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion, Yang, Liang, Tang, Haite, Lin, Xiaobing, Wu, Yi, Zeng, Sheng, Li, Yukun, Xiang, Ge, Lin, YiFang, Zhuang, ShiMei, Song, Zhiyin, Jiang, Yiguo, Liu, Xingguo, 2020 Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, Chen, Keshi, Long, Qi, Xing, Guangsuo, Wang, Tianyu, Wu, Yi, Li, Linpeng, Qi, Juntao, Zhou, Yanshuang, Ma, Bochao, Schoeler, Hans R, Nie, Jinfu, Pei, Duanqing, Liu, Xingguo, 2020 Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, Wu, Yi, Chen, Keshi, Xing, Guangsuo, Li, Linpeng, Ma, Bochao, Hu, Zhijuan, Duan, Lifan, Liu, Xingguo, 2019 Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition, Liu, Xingguo, 2019 Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming, Ying, Zhongfu, Xiang, Ge, Zheng, Lingjun, Tang, Haite, Duan, Lifan, Lin, Xiaobing, Zhao, Qiuge, Chen, Keshi, Wu, Yi, Xing, Guangsuo, Lv, Yiwang, Li, Linpeng, Yang, Liang, Bao, Feixiang, Long, Qi, Zhou, Yanshuang, He, Xueying, Wang, Yaofeng, Gao, Minghui, Pei, Duanqing, Chan, WaiYee, Liu, Xingguo, 2018 Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, Bao, Feixiang, Shi, Hongyan, Gao, Mi, Yang, Liang, Zhou, Lingyan, Zhao, Qiuge, Wu, Yi, Chen, Keshi, Xiang, Ge, Long, Qi, Guo, Jingyi, Zhang, Jian, Liu, Xingguo, 2018 Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes, Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Liu, Xingguo, Chen, Yu, Ji, Liangnian, Chao, Hui, 2017 Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(III) complexes, Cao, JianJun, Tan, CaiPing, Chen, MuHe, Wu, Na, Yao, DeYang, Liu, XingGuo, Ji, LiangNian, Mao, ZongWan, 2017 BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Xiang, Ge, Yang, Liang, Long, Qi, Chen, Keshi, Tang, Haite, Wu, Yi, Liu, Zihuang, Zhou, Yanshuang, Qi, Juntao, Zheng, Lingjun, Liu, Wenbo, Ying, Zhongfu, Fan, Weimin, Shi, Hongyan, Li, Hongmei, Lin, Xiaobing, Gao, Mi, Liu, Jinglei, Bao, Feixiang, Li, Linpeng, Duan, Lifan, Li, Min, Liu, Xingguo, 2017 Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes, Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Chen, Yu, Liu, Xingguo, Ji, Liangnian, Chao, Hui, 2017 BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming, Liu, Xingguo, 2017 Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Li, Linpeng, Chen, Keshi, Wu, Yi, Long, Qi, Zhao, Danyun, Ma, Bochao, Pei, Duanqing, Liu, Xingguo, 2017 Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells, Liu Xingguo, Yang Liang, Long Qi, Weaver David, Hajnoczky Gyorgy, 2017 Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, Wu, Yi, Chen, Keshi, Liu, Xiyin, Huang, Lili,

Areas of Focus

Role of metabolic changes and mitochondria in stem cell fate regulation
Role of cell signaling in stem cell fate regulation
Mechanism of human mitochondrial diseases and stem cell therapy

Publications

MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Xing, Guangsuo, Liu, Zichao, Huang, Luyuan, Zhao, Danyun, Wang, Tao, Yuan, Hao, Wu, Yi, Li, Linpeng, Long, Qi, Zhou, Yanshuang, Hao, Zhihong, Liu, Yang, Lu, Jianghuan, Li, Shiting, Zhu, Jieying, Wang, Bo, Wang, Junwei, Liu, Jing, Chen, Jiekai, Pei, Duanqing, Liu, Xingguo, Chen, Keshi, 2022
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation, Li, Wei, Long, Qi, Wu, Hao, Zhou, Yanshuang, Duan, Lifan, Yuan, Hao, Ding, Yingzhe, Huang, Yile, Wu, Yi, Huang, Jinyu, Liu, Delong, Chen, Baodan, Zhang, Jian, Qi, Juntao, Du, Shiwei, Li, Linpeng, Liu, Yang, Ruan, Zifeng, Liu, Zihuang, Liu, Zichao, Zhao, Yifan, Lu, Jianghuan, Wang, Junwei, Chan, WaiYee, Liu, Xingguo, 2022
Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms, Liu, Xingguo, 2022
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation (vol 28, pg 900, 2021), Long, Qi, Zhou, Yanshuang, Wu, Hao, Du, Shiwei, Hu, Mingli, Qi, Juntao, Li, Wei, Guo, Jingyi, Wu, Yi, Yang, Liang, Xiang, Ge, Wang, Liang, Ye, Shouhua, Wen, Jiayuan, Mao, Heng, Wang, Junwei, Zhao, Hui, Chan, WaiYee, Liu, Jinsong, Chen, Yonglong, Li, Pilong, Liu, Xingguo, 2021
Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space, Liu, Xingguo, 2021
A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome, Guo, Jingyi, Duan, Lifan, He, Xueying, Li, Shengbiao, Wu, Yi, Xiang, Ge, Bao, Feixiang, Yang, Liang, Shi, Hongyan, Gao, Mi, Zheng, Lingjun, Hu, Huili, Liu, Xingguo, 2021
A new sight: topology-dependent mitophagy, Zhou, Yanshuang, Long, Qi, Liu, Xingguo, 2020
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, Li, Linpeng, Chen, Keshi, Wang, Tianyu, Wu, Yi, Xing, Guangsuo, Chen, Mengqi, Hao, Zhihong, Zhang, Cheng, Zhang, Jinye, Ma, Bochao, Liu, Zihuang, Yuan, Hao, Liu, Zijian, Long, Qi, Zhou, Yanshuang, Qi, Juntao, Zhao, Danyun, Gao, Mi, Pei, Duanqing, Nie, Jinfu, Ye, Dan, Pan, Guangjin, Liu, Xingguo, 2020
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+)redox, Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo, 2020
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade, Liu, Xingguo, 2020
线粒体定位circRNA调控肝脏免疫代谢性炎症机制, 苏士成, 宋保亮, 陈玲玲, 刘兴国, 2020
Topology-dependent, bifurcated mitochondrial quality control under starvation, Zhou, Yanshuang, Long, Qi, Wu, Hao, Li, Wei, Qi, Juntao, Wu, Yi, Xiang, Ge, Tang, Haite, Yang, Liang, Chen, Keshi, Li, Linpeng, Bao, Feixiang, Li, Heying, Wang, Yaofeng, Li, Min, Liu, Xingguo, 2020
OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion, Yang, Liang, Tang, Haite, Lin, Xiaobing, Wu, Yi, Zeng, Sheng, Li, Yukun, Xiang, Ge, Lin, YiFang, Zhuang, ShiMei, Song, Zhiyin, Jiang, Yiguo, Liu, Xingguo, 2020
Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, Chen, Keshi, Long, Qi, Xing, Guangsuo, Wang, Tianyu, Wu, Yi, Li, Linpeng, Qi, Juntao, Zhou, Yanshuang, Ma, Bochao, Schoeler, Hans R, Nie, Jinfu, Pei, Duanqing, Liu, Xingguo, 2020
Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, Wu, Yi, Chen, Keshi, Xing, Guangsuo, Li, Linpeng, Ma, Bochao, Hu, Zhijuan, Duan, Lifan, Liu, Xingguo, 2019
Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition, Liu, Xingguo, 2019
Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming, Ying, Zhongfu, Xiang, Ge, Zheng, Lingjun, Tang, Haite, Duan, Lifan, Lin, Xiaobing, Zhao, Qiuge, Chen, Keshi, Wu, Yi, Xing, Guangsuo, Lv, Yiwang, Li, Linpeng, Yang, Liang, Bao, Feixiang, Long, Qi, Zhou, Yanshuang, He, Xueying, Wang, Yaofeng, Gao, Minghui, Pei, Duanqing, Chan, WaiYee, Liu, Xingguo, 2018
Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, Bao, Feixiang, Shi, Hongyan, Gao, Mi, Yang, Liang, Zhou, Lingyan, Zhao, Qiuge, Wu, Yi, Chen, Keshi, Xiang, Ge, Long, Qi, Guo, Jingyi, Zhang, Jian, Liu, Xingguo, 2018
Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes, Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Liu, Xingguo, Chen, Yu, Ji, Liangnian, Chao, Hui, 2017
Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(III) complexes, Cao, JianJun, Tan, CaiPing, Chen, MuHe, Wu, Na, Yao, DeYang, Liu, XingGuo, Ji, LiangNian, Mao, ZongWan, 2017
BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Xiang, Ge, Yang, Liang, Long, Qi, Chen, Keshi, Tang, Haite, Wu, Yi, Liu, Zihuang, Zhou, Yanshuang, Qi, Juntao, Zheng, Lingjun, Liu, Wenbo, Ying, Zhongfu, Fan, Weimin, Shi, Hongyan, Li, Hongmei, Lin, Xiaobing, Gao, Mi, Liu, Jinglei, Bao, Feixiang, Li, Linpeng, Duan, Lifan, Li, Min, Liu, Xingguo, 2017
Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes, Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Chen, Yu, Liu, Xingguo, Ji, Liangnian, Chao, Hui, 2017
BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming, Liu, Xingguo, 2017
Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Li, Linpeng, Chen, Keshi, Wu, Yi, Long, Qi, Zhao, Danyun, Ma, Bochao, Pei, Duanqing, Liu, Xingguo, 2017
Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells, Liu Xingguo, Yang Liang, Long Qi, Weaver David, Hajnoczky Gyorgy, 2017
Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, Wu, Yi, Chen, Keshi, Liu, Xiyin, Huang, Lili,

Metabolic Changes Mitochondria Stem Cell Fate Cell Signaling Mitochondrial Diseases Stem Cell Therapy Regulation Mechanism Human Diseases Therapy

Yu-Bo Zhou - University of Chinese Academy of Sciences

Min Liu - Wuhan University

Honglei Chen - Wuhan University

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