2001-03--2005-04 PhD: Shanghai Jiao Tong University
1994-09--2000-07 Bachelor's + Master's: Huazhong Agricultural University
2006-08~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher
2005-04~2006-07 - National Human Genome South Research Center - Assistant Researcher
2001-03~2005-04 - Shanghai Jiao Tong University - PhD
1994-09~2000-07 - Huazhong Agricultural University - Bachelor's + Master's
Research
Protein Homeostasis Regulation Personalized Innovative Drug Research Traditional Chinese Medicine Pharmacology
Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia., 11th Author, 2023
Discovery of a Potent and Selective Degrader for USP7, 11th Author, 2022
Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins, 10th Author, 2022
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, 11th Author, 2022
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, 11th Author, 2022
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia, 11th Author, 2022
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, 7th Author, 2021
Synthesis of 2-ethoxycarbonylthieno2,3-bquinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B, 11th Author, 2021
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 19th Author, 2021
Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, 13th Author, 2021
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, 11th Author, 2021
Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity, 6th Author, 2021
Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors, 11th Author, 2021
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, 11th Author, 2021
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, 11th Author, 2021
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia, 11th Author, 2021
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening, 11th Author, 2021
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening, 11th Author, 2021
Development of peptide epoxyketones as selective immunoproteasome inhibitors, 11th Author, 2021
Determination of maytansinoids in Trewia nudiflora using QuEChERS extraction combined with HPLC, 11th Author, 2021
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors, 11th Author, 2020
Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii, 6th Author, 2020
Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer, 9th Author, 2020
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo, 5th Author, 2020
Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction, 4th Author, 2020
Design, Synthesis, and In Vitro Evaluation of Benzofuro3,2- c Quinoline Derivatives as Potential Antileukemia Agents, 7th Author, 2020
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla, 7th Author, 2020
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells, 12th Author, 2020
New Steroids from the South China Sea Soft Coral Lobophytum sp., 2nd Author, 2020
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, 7th Author, 2019
Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model, 11th Author, 2019
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles, 11th Author, 2019
Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation, 11th Author, 2019
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies, 10th Author, 2019
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design, 8th Author, 2019
Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors, 7th Author, 2019
Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis, 6th Author, 2019
Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor, 11th Author, 2019
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors, 11th Author, 2019
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors, 6th Author, 2019
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors, 11th Author, 2019
3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluation, 8th Author, 2018
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors, 11th Author, 2018
A series of camptothecin prodrugs exhibit HDAC inhibition activity, 6th Author, 2018
Convenient preparation
Keywords
Protein HomeostasisRegulationProteinsCell BiologyMolecular BiologyBiochemistryCell SignalingProtein DegradationProtein SynthesisProtein FoldingPersonalized MedicineInnovative DrugsDrug DevelopmentPharmacologyClinical TrialsBiotechnologyMolecular MedicineTargeted TherapyPrecision MedicineDrug DiscoveryTraditional Chinese MedicineHerbal MedicineNatural ProductsChinese HerbsPhytochemistryEthnopharmacologyMedicinal PlantsAlternative MedicineIntegrative Medicine
