Areas of Focus
- Protein Homeostasis Regulation
- Personalized Innovative Drug Research
- Traditional Chinese Medicine Pharmacology
Work Experience
- 2006-08~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher
- 2005-04~2006-07 - National Human Genome South Research Center - Assistant Researcher
- 2001-03~2005-04 - Shanghai Jiao Tong University - PhD
- 1994-09~2000-07 - Huazhong Agricultural University - Bachelor's + Master's
Academic Background & Achievements
- 2001-03--2005-04 PhD: Shanghai Jiao Tong University
- 1994-09--2000-07 Bachelor's + Master's: Huazhong Agricultural University
Publications
- Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia., 11th Author, 2023
- Discovery of a Potent and Selective Degrader for USP7, 11th Author, 2022
- Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins, 10th Author, 2022
- Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, 11th Author, 2022
- Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, 11th Author, 2022
- Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia, 11th Author, 2022
- 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, 7th Author, 2021
- Synthesis of 2-ethoxycarbonylthieno2,3-bquinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B, 11th Author, 2021
- SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 19th Author, 2021
- Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, 13th Author, 2021
- Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, 11th Author, 2021
- Divalent tranylcypromine derivative as lysine-specific demethylase 1 inhibitor, 11th Author, 2021
- Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity, 6th Author, 2021
- Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors, 11th Author, 2021
- Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, 11th Author, 2021
- Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, 11th Author, 2021
- Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia, 11th Author, 2021
- Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening, 11th Author, 2021
- Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening, 11th Author, 2021
- Development of peptide epoxyketones as selective immunoproteasome inhibitors, 11th Author, 2021
- Determination of maytansinoids in Trewia nudiflora using QuEChERS extraction combined with HPLC, 11th Author, 2021
- Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors, 11th Author, 2020
- Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii, 6th Author, 2020
- Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer, 9th Author, 2020
- Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo, 5th Author, 2020
- Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction, 4th Author, 2020
- Design, Synthesis, and In Vitro Evaluation of Benzofuro3,2- c Quinoline Derivatives as Potential Antileukemia Agents, 7th Author, 2020
- Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla, 7th Author, 2020
- Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells, 12th Author, 2020
- New Steroids from the South China Sea Soft Coral Lobophytum sp., 2nd Author, 2020
- Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, 7th Author, 2019
- Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model, 11th Author, 2019
- Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles, 11th Author, 2019
- Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation, 11th Author, 2019
- Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies, 10th Author, 2019
- Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design, 8th Author, 2019
- Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors, 7th Author, 2019
- Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis, 6th Author, 2019
- Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor, 11th Author, 2019
- Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors, 11th Author, 2019
- Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors, 6th Author, 2019
- Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors, 11th Author, 2019
- 3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluation, 8th Author, 2018
- Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors, 11th Author, 2018
- A series of camptothecin prodrugs exhibit HDAC inhibition activity, 6th Author, 2018
- Convenient preparation
