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Huiling Cao
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Osteoclasts
Osteoblasts
Differentiation
Bone Remodeling
Cancer Metastasis
Bone Angiogenesis
Molecular Biology
Cell Signaling
Pathophysiology
Therapeutic Targets
Areas of Focus
- Molecular mechanisms of osteoclast and osteoblast formation and differentiation
- Molecular mechanisms of bone remodeling
- Cancer bone metastasis
- Molecular mechanisms of bone angiogenesis
Work Experience
- 2021/04 - Present: Researcher, Medical School, Southern University of Science and Technology
- 2020/03-2021/03: Associate Professor (Associate Researcher), Medical School, Southern University of Science and Technology
- 2017/01-2020/02: Associate Professor (Associate Researcher), Department of Biology, Southern University of Science and Technology
- 2014/11-2016/12: Lecturer, Department of Biology, Southern University of Science and Technology
- 2010/07-2011/08: Postdoctoral Fellow, Medical School, University of Pittsburgh
Academic Background & Achievements
- 2004-2010 PhD in Immunology, Joint program between Tianjin Medical University and University of Pittsburgh
- Published multiple papers in top-tier journals
- Received three patents
Publications
- Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone, Yu S., Franceschi R.T., Luo M., Fan J., Jiang D., Cao H., Kwon T.G., Lai Y., Zhang J., Patrene K., Hankenson K., Roodman G.D., and Xiao G., 2009
- Activating transcription factor 4 regulates osteoclast differentiation in mice, Cao H., Yu S., Yao Z., Galson D.L., Jiang Y., Zhang X., Fan J., Lu B., Guan Y., Luo M., Lai Y., Zhu Y., Kurihara N., Patrene K., Roodman G.D., and Xiao G., 2010
- Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts, Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., and Xiao G., 2011
- Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling, Xiao G., Cheng H., Cao H., Chen K., Tu Y., Yu S., Jiao H., Yang S., Im H.J., Chen D., Chen J., and Wu C., 2012
- Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease, Teramachi J., Hiruma Y., Ishizuka S., Ishizuka H., Brown J.P., Michou L., Cao H., Galson D.L., Subler M.A., Zhou H., Dempster D.W., Windle J.J., Roodman G.D., and Kurihara N., 2013
- ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment, Zhu K., Jiao H., Li S., Cao H., Galson D.L., Zhao Z., Zhao X., Lai Y., Fan J., Im H.J., Chen D., and Xiao G., 2013
- Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis, Cao H., Zhu K., Qiu L., Li S., Niu H., Hao M., Yang S., Zhao Z., Lai Y., Anderson J.L., Fan J., Im H.J., Chen D., Roodman G.D., and Xiao G., 2013
- Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells, Qin T.T., Xu G.C., Qi J.W., Yang G.L., Zhang K., Liu H.L., Xu L.X., Xiang R., Xiao G., Cao H., Wei Y., Zhang Q.Z., and Li L.Y., 2015
- Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis, Wu C., Jiao H., Lai Y., Zheng W., Chen K., Qu H., Deng W., Song P., Zhu K., Cao H., Galson D.L., Fan J., Im H.J., Liu Y., Chen J., Chen D., and Xiao G., 2015
- ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming, Yang X., Xia R., Yue C., Zhai W., Du W., Yang Q., Cao H., Chen X., Obando D., Zhu Y., Chen X., Chen J.J., Piganelli J., Jiang Y., Xiao G., Wu C., Jiang J., and Lu B., 2018
- Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2, Gao H., Guo Y., Yan Q., Yang W., Li R., Lin S., Bai X., Liu C., Chen D., Cao H., and Xiao G., 2019
- Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice, Wang Y., Yan Q., Zhao Y., Liu X., Lin S., Zhang P., Ma L., Lai Y., Bai X., Liu C., Wu C., Feng J.Q., Chen D., Cao H., and Xiao G., 2019
- Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice, Cao H., Yan Q., Wang D., Lai Y., Zhou B., Zhang Q., Jin W., Lin S., Lei Y., Ma L., Guo Y., Wang Y., Wang Y., Bai X., Liu C., Feng J.Q., Wu C., Chen D., Cao X., and Xiao G., 2020
- Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice, Zhu K., Lai Y., Cao H., Bai X., Liu C., Yan Q., Ma L., Chen D., Kanaporis G., Wang J., Li L., Cheng T., Wang Y., Wu C., and Xiao G., 2020
- Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells, Chen S., Qin L., Wu X., Fu X., Lin S., Chen D., Xiao G., Shao Z., and Cao H., 2020
- LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice, Lei Y., Fu X., Li P., Lin S., Yan Q., Lai Y., Liu X., Wang Y., Bai X., Liu C., Chen D., Cao H., Xiao G., 2020
- Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice, Fu X., Zhou B., Yan Q., Tao C., Qin L., Wu X., Lin S., Chen S., Lai Y., Zou X., Shao Z., Wang M., Chen D., Jin W., Song Y., Cao H., Zhang G., and Xiao G., 2020
- Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes, Qin L., Fu X., Ma J., Lin M., Zhang P., Wang Y., Yan Q., Tao C., Liu W., Tang B., Chen D., Bai X., Cao H., Xiao G., 2021
- Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice, Gao H., Zhong Y., Ding Z., Lin S., Hou X., Tang W., Zhou X., Zou X., Shao J., Yang F., Bai X., Liu C., Cao H., Xiao G., 2021
- Kindlin-2 inhibits NLRP3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc, Chen S., Wu X., Lai Y., Chen D., Bai X., Liu S., Wu Y., Cao H., Shao Z., Xiao G., 2022
- Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis, Wu X., Lai Y., Chen S., Zhou C., Tao C., Fu X., Li J., Huang J., Tong W., Tian H., Shao Z., Liu C., Chen D., Bai X., Cao H., Xiao G., 2022
- Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice, Gao H., Zhou L., Zhong Y., Ding Z., Lin S., Hou X., Zhou X., Shao J., Yang F., Zou X., Cao H., Xiao G., 2022
- A novel sprayable thermosensitive hydrogel coupled with
Awards
- 2016 ASBMR Young Investigator Travel Grant, Plenary Poster, ASBMR 2016 Annual Meeting
- 2012 Chinese National Excellent Doctoral Dissertation nomination
- 2012 Excellent Doctoral Dissertation Award, Tianjin city, China
- 2011 ASBMR Young Investigator Award, ASBMR annual meeting
- 2011 Young Investigator Award, 9th International Conference on Bone and Mineral Research & 11th International Osteoporosis Symposium
- 2010 Excellent PhD Graduate Award, Tianjin Medical University
