Areas of Focus
- Molecular Mechanisms of Virus-Host Interactions
- Co-infection and Inhibition of HSV-2/HIV-1
- Self-replicating RNA Vaccines
- HIV-1 Inhibitors
- Antiviral Drug Research
Work Experience
- 2018-09~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher
- 2010-07~2018-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher
- 2005-09~2010-06 - Wuhan Institute of Virology, Chinese Academy of Sciences - Ph.D. Student
- 2003-08~2005-06 - Gong'an County No.1 High School, Hubei Province - Biology Teacher
- 1999-09~2003-06 - Hubei University - Bachelor's Degree in Science
Academic Background & Achievements
- 2005-09--2010-06 Ph.D.: Wuhan Institute of Virology, Chinese Academy of Sciences
- 1999-09--2003-06 Bachelor's Degree in Science: Hubei University
Publications
- Tat-dependent conditionally replicating adenoviruses expressing diphtheria toxin A for specifically killing HIV-1-infected cells, 11th Author, 2024
- Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses, 11th Author, 2023
- Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread, 11th Author, 2023
- Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22), 11th Author, 2022
- A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration, 11th Author, 2021
- Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-kB Activation by Interacting with p65, 11th Author, 2021
- Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells, 7th Author, 2020
- Self-assembled fluorescent Ce(III) coordination polymer as ratiometric probe for HIV antigen detection, 9th Author, 2019
- Hsv-2 glycoprotein j promotes viral protein expression and virus spread, 1st Author, 2018
- Tick-borne encephalitis virus nonstructural protein ns5 induces rantes expression dependent on the rna-dependent rna polymerase activity, 11th Author, 2018
- Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 + T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4, 12th Author, 2018
- DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses, 11th Author, 2017
- Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E, 11th Author, 2017
- DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein, 14th Author, 2016
- HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway, 11th Author, 2016
- HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter, 2nd Author, 2015
- Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin, 5th Author, 2015
- Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge, 10th Author, 2015
- Inhibition of HIV-1 infection of primary CD4(+) T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9, 6th Author, 2015
- Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins, 1st Author, 2015
- Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry, 9th Author, 2015
- Binding of HIV-1 virions to α4β7 expressing cells and impact of antagonizing α4β7 on HIV-1 infection of primary CD4+ T cells, 5th Author, 2014
- Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES, 1st Author, 2012
- Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4(+) T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-beta Pathway, 7th Author, 2012
- Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci, 4th Author, 2009
- The tegument protein UL94 of human cytomegalovirus as a binding partner for tegument protein pp28 identified by intracellular imaging, 1st Author, 2009
