Areas of Focus
- 病毒与宿主相互作用的分子机制
- HSV-2/HIV-1的共感染及抑制
- 自复制RNA疫苗
- HIV-1抑制剂
- 抗病毒药物研究
Work Experience
- 2018-09~现在 - 中国科学院武汉病毒研究所 - 副研究员
- 2010-07~2018-08 - 中国科学院武汉病毒研究所 - 助理研究员
- 2005-09~2010-06 - 中国科学院武汉病毒研究所 - 博士学位
- 2003-08~2005-06 - 湖北省公安县第一高级中学 - 生物教师
- 1999-09~2003-06 - 湖北大学 - 理学学士
Academic Background & Achievements
- 2005-09--2010-06 博士学位: 中国科学院武汉病毒研究所
- 1999-09--2003-06 理学学士: 湖北大学
Publications
- Tat-dependent conditionally replicating adenoviruses expressing diphtheria toxin A for specifically killing HIV-1-infected cells, 第11作者, 2024
- Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses, 第11作者, 2023
- Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread, 第11作者, 2023
- Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22), 第11作者, 2022
- A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration, 第11作者, 2021
- Herpes Simplex Virus Type 2 Glycoprotein D Inhibits NF-kB Activation by Interacting with p65, 第11作者, 2021
- Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells, 第7作者, 2020
- Self-assembled fluorescent Ce(III) coordination polymer as ratiometric probe for HIV antigen detection, 第9作者, 2019
- Hsv-2 glycoprotein j promotes viral protein expression and virus spread, 第1作者, 2018
- Tick-borne encephalitis virus nonstructural protein ns5 induces rantes expression dependent on the rna-dependent rna polymerase activity, 第11作者, 2018
- Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 + T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4, 第12作者, 2018
- DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses, 第11作者, 2017
- Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E, 第11作者, 2017
- DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein, 第14作者, 2016
- HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway, 第11作者, 2016
- HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter, 第2作者, 2015
- Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin, 第5作者, 2015
- Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge, 第10作者, 2015
- Inhibition of HIV-1 infection of primary CD4(+) T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9, 第6作者, 2015
- Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins, 第1作者, 2015
- Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry, 第9作者, 2015
- Binding of HIV-1 virions to α4β7 expressing cells and impact of antagonizing α4β7 on HIV-1 infection of primary CD4+ T cells, 第5作者, 2014
- Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES, 第1作者
