Professor | Xiaoxia Lu | Asia Growth Partners

Name	Xiaoxia Lu
Contact Information	luxx@cib.ac.cn
Language ability	Chinese, English
Province	Sichuan

Name

Xiaoxia Lu

Contact Information

luxx@cib.ac.cn

Language ability

Chinese, English

Province

Sichuan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2000-08--2004-02 Postdoctoral: University of Hong Kong 1997-09--2000-07 PhD: Sichuan University, University of Hong Kong
Work Experience	2010-08~2011-08 - Washington University in St. Louis - Visiting Scholar 2004-04~Present - Chengdu Institute of Biology, Chinese Academy of Sciences - Researcher 2000-08~2004-02 - University of Hong Kong - Visiting Scholar

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2000-08--2004-02 Postdoctoral: University of Hong Kong
1997-09--2000-07 PhD: Sichuan University, University of Hong Kong

Work Experience

2010-08~2011-08 - Washington University in St. Louis - Visiting Scholar
2004-04~Present - Chengdu Institute of Biology, Chinese Academy of Sciences - Researcher
2000-08~2004-02 - University of Hong Kong - Visiting Scholar

Areas of Focus	Organic Chemistry Medicinal Chemistry Natural Medicines Glycochemistry Molecular Targeted Drugs
Publications	Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors, Liu, Gang, Mondal, Prasenjit, Sang, Na, Li, Zihuai, Ding, Weihua, Yang, Liuyue, Liu, Yan, Birar, Vishal C, Gomm, Ashley, Tanzi, Rudolph E, Zhang, Can, Shen, Shiqian, Wang, Changning, Lu, Xiaoxia, Bai, Ping, 2023 Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC) Inhibitors Against Hepatocellular Carcinoma Cells, Shi Hailong, Yang Jinlian, Qiao Zenen, Lingyu Li, Liu Gang, Dai Qi, Xu Li, Jiao Wei, Zhang Guolin, Wang Fei, Lu Xiaoxia, Ma Xiaofeng, 2023 1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction, Shi Hailong, Yang Jian, Cheng Yao, Lu Xiaoxia, Ma Xiaofeng, 2022 Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP- Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Peng, Ting, He, Yujiao, Wang, Tao, Yu, Jialing, Ma, Xiaofang, Zhou, Zongyuan, Sheng, Yuwen, Li, Lingyu, Peng, Huipan, Li, Sheng, Zou, Jiawei, Yuan, Yi, Zhao, Yongyun, Shi, Hailong, Li, Fu, Liu, Wanli, Hu, Kaifeng, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, 2022 选择性HDAC6抑制剂4-（（2，4-二氧基-3-苯乙基-3，4-二氢喹唑啉-1（2 H）-基）-甲基）-N-羟基苯甲酰胺的合成, 杨建, 石海龙, 刘钢, 卢晓霞, 2022 Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo, Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang, 2022 Discovery of a Positron Emission Tomography Radiotracer Selectively Targeting the BD1 Bromodomains of BET Proteins, Ping Bai, Xiaoxia Lu, Yan Liu, Yu Lan, Hao Wang, Stephanie Fiedler, Robin Striar, Changning Wang, 2021 Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins, Bai, Ping, Lu, Xiaoxia, Lan, Yu, Chen, Zude, Patnaik, Debasis, Fiedler, Stephanie, Striar, Robin, Haggarty, Stephen J, Wang, Changning, 2020 Design, Synthesis, and Insecticidal Activity of Novel Doramectin Derivatives Containing Acylurea and Acylthiourea Based on Hydrogen Bonding, Zhang, Qi, Cheng, Yao, Zheng, Cheng, Bai, Ping, Yang, Jian, Lu, Xiaoxia, 2020 Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins, Bai, Ping, Lan, Yu, Wang, Hao, Chen, Zude, Fiedler, Stephanie, Striar, Robin, Lu, Xiaoxia, Wang, Changning, 2020 盐霉素原料药中新杂质的检测、分离、鉴定及抗肿瘤活性, 程瑶, 熊峰, 王涛, 谢昌贤, 云喜报, 张国林, 卢晓霞, 2020 Isolation,identiﬁcation,andcharacterizationofpotentialimpuritiesofdoramectinandevaluationoftheirinsecticidalactivity, 卢晓霞, 2020 Isolation, identification, and characterization of potential impurities of doramectin and evaluation of their insecticidal activity, Zhang, Qi, Cheng, Yao, Yang, Jian, Zheng, Cheng, Lu, Xiaoxia, 2020 Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells, Ebokaiwe, Azubuike Peter, Njoya, Emmanuel Mfotie, Sheng, Yuwen, Zhang, Zhonghui, Li, Sheng, Zhou, Zongyuan, Qiang, Zhe, Peng, Ting, Hussein, Ahmed A, Zhang, Guolin, Lu, Xiaoxia, Li, Lin, Wang, Fei, 2020 A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging, Bai, Ping, Bai, Sha, Placzek, Michael S, Lu, Xiaoxia, Fiedler, Stephanie A, Ntaganda, Brenda, Wey, HsiaoYing, Wang, Changning, 2020 Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease, Bai, Ping, Wang, Keren, Zhang, Pengfei, Shi, Jian, Cheng, Xinfeng, Zhang, Qi, Zheng, Cheng, Cheng, Yao, Yang, Jian, Lu, Xiaoxia, Sang, Zhipei, 2019 Design, synthesis, insecticidal activity and molecular docking of doramectin derivatives, Zhang, Qi, Bai, Ping, Zheng, Cheng, Cheng, Yao, Wang, Tao, Lu, Xiaoxia, 2019 Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1, Wu, Jiasi, Luo, Yu, Jiang, Qing, Li, Sheng, Huang, Wenge, Xiang, Li, Liu, Deming, Hu, Yingfan, Wang, Ping, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, Meng, Xianli, 2019 Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging, Bai, Ping, Wey, HsiaoYing, Patnaik, Debasis, Lu, Xiaoxia, Lan, Yu, Rokka, Johanna, Stephanie, Fiedler, Haggarty, Stephen J, Wang, Changning, 2019 盐霉素类似物的分离及抑制吲哚胺2，3-双加氧酶活性研究, 郑城, 王涛, 谢昌贤, 云喜报, 卢晓霞, 2019 Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities, Wen, Yongju, Zhou, Zongyuan, Zhang, Guolin, Lu, Xiaoxia, 2018 Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethyl-2,3-dehydrosilybin from silybin and their antitumor activities, Yongju Wen, Zongyuan Zhou, Guolin Zhang, Xiaoxia Lu, 2018 脂肪酶催化吉法酯的合成研究, 王涛, 熊峰, 赵澜宁, 卢晓霞, 2018 具抗病毒黄精寡糖核心片段的分离纯化与四糖结构, 万振江, 潘伟, 卢晓霞, 2017 σ1受体配体的合成及其生物活性, 张琪, 赵澜宁, 潘伟, 王涛, 卢晓霞, 2017 Isolation, identification and characterization of potential impurities of anidulafungin, Zhao, Lanning, Wang, Qilong, Bie, Yi, Lu, Xiaoxia, 2017 Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids, Lan, Jianyong, Xie, Haisheng, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huanfeng, Zeng, Wei, 2017 Copper-Catalyzed Addition of Alkylboranes to Iminoacetates: Access to alpha-Alkyl Branched alpha-Amino Acids, Xiao, Xinsheng, Zhang, Wei, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huangfeng, Zeng, Wei, 2016 Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated C-sp(3)-H Bonds, Liu, Jianzhong, Xie, Ying, Zeng, Wei, Lin, Dongen, Deng, Yuanfu, Lu, Xiaoxia, 2015 炔醛参与的直接Mannich反应, 黄涌澜, 董理进, 王超, 卢晓霞, 孙健, 2013 Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of alpha-Imino Esters with Dienes, Zhu, Shujie, Lu, Xiaoxia, Luo, Yueting, Zhang, Wei, Jiang, Huanfeng, Yan, Ming, Zeng, Wei, 2013 Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of r?Imino Esters with Dienes, 卢晓霞, 2013 Palladium-Catalyzed Cascade Oxidation/sp(2) C-H Acylation of Azoarenes with Aryl Methanes, Xiong, Feng, Qian, Cheng, Lin, Dongen, Zeng, Wei, Lu, Xiaoxia, 2013 Pd-Catalyzed Tand

Areas of Focus

Organic Chemistry
Medicinal Chemistry
Natural Medicines
Glycochemistry
Molecular Targeted Drugs

Publications

Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors, Liu, Gang, Mondal, Prasenjit, Sang, Na, Li, Zihuai, Ding, Weihua, Yang, Liuyue, Liu, Yan, Birar, Vishal C, Gomm, Ashley, Tanzi, Rudolph E, Zhang, Can, Shen, Shiqian, Wang, Changning, Lu, Xiaoxia, Bai, Ping, 2023
Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC) Inhibitors Against Hepatocellular Carcinoma Cells, Shi Hailong, Yang Jinlian, Qiao Zenen, Lingyu Li, Liu Gang, Dai Qi, Xu Li, Jiao Wei, Zhang Guolin, Wang Fei, Lu Xiaoxia, Ma Xiaofeng, 2023
1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction, Shi Hailong, Yang Jian, Cheng Yao, Lu Xiaoxia, Ma Xiaofeng, 2022
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP- Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Peng, Ting, He, Yujiao, Wang, Tao, Yu, Jialing, Ma, Xiaofang, Zhou, Zongyuan, Sheng, Yuwen, Li, Lingyu, Peng, Huipan, Li, Sheng, Zou, Jiawei, Yuan, Yi, Zhao, Yongyun, Shi, Hailong, Li, Fu, Liu, Wanli, Hu, Kaifeng, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, 2022
选择性HDAC6抑制剂4-（（2，4-二氧基-3-苯乙基-3，4-二氢喹唑啉-1（2 H）-基）-甲基）-N-羟基苯甲酰胺的合成, 杨建, 石海龙, 刘钢, 卢晓霞, 2022
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo, Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang, 2022
Discovery of a Positron Emission Tomography Radiotracer Selectively Targeting the BD1 Bromodomains of BET Proteins, Ping Bai, Xiaoxia Lu, Yan Liu, Yu Lan, Hao Wang, Stephanie Fiedler, Robin Striar, Changning Wang, 2021
Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins, Bai, Ping, Lu, Xiaoxia, Lan, Yu, Chen, Zude, Patnaik, Debasis, Fiedler, Stephanie, Striar, Robin, Haggarty, Stephen J, Wang, Changning, 2020
Design, Synthesis, and Insecticidal Activity of Novel Doramectin Derivatives Containing Acylurea and Acylthiourea Based on Hydrogen Bonding, Zhang, Qi, Cheng, Yao, Zheng, Cheng, Bai, Ping, Yang, Jian, Lu, Xiaoxia, 2020
Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins, Bai, Ping, Lan, Yu, Wang, Hao, Chen, Zude, Fiedler, Stephanie, Striar, Robin, Lu, Xiaoxia, Wang, Changning, 2020
盐霉素原料药中新杂质的检测、分离、鉴定及抗肿瘤活性, 程瑶, 熊峰, 王涛, 谢昌贤, 云喜报, 张国林, 卢晓霞, 2020
Isolation,identiﬁcation,andcharacterizationofpotentialimpuritiesofdoramectinandevaluationoftheirinsecticidalactivity, 卢晓霞, 2020
Isolation, identification, and characterization of potential impurities of doramectin and evaluation of their insecticidal activity, Zhang, Qi, Cheng, Yao, Yang, Jian, Zheng, Cheng, Lu, Xiaoxia, 2020
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells, Ebokaiwe, Azubuike Peter, Njoya, Emmanuel Mfotie, Sheng, Yuwen, Zhang, Zhonghui, Li, Sheng, Zhou, Zongyuan, Qiang, Zhe, Peng, Ting, Hussein, Ahmed A, Zhang, Guolin, Lu, Xiaoxia, Li, Lin, Wang, Fei, 2020
A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging, Bai, Ping, Bai, Sha, Placzek, Michael S, Lu, Xiaoxia, Fiedler, Stephanie A, Ntaganda, Brenda, Wey, HsiaoYing, Wang, Changning, 2020
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease, Bai, Ping, Wang, Keren, Zhang, Pengfei, Shi, Jian, Cheng, Xinfeng, Zhang, Qi, Zheng, Cheng, Cheng, Yao, Yang, Jian, Lu, Xiaoxia, Sang, Zhipei, 2019
Design, synthesis, insecticidal activity and molecular docking of doramectin derivatives, Zhang, Qi, Bai, Ping, Zheng, Cheng, Cheng, Yao, Wang, Tao, Lu, Xiaoxia, 2019
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1, Wu, Jiasi, Luo, Yu, Jiang, Qing, Li, Sheng, Huang, Wenge, Xiang, Li, Liu, Deming, Hu, Yingfan, Wang, Ping, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, Meng, Xianli, 2019
Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging, Bai, Ping, Wey, HsiaoYing, Patnaik, Debasis, Lu, Xiaoxia, Lan, Yu, Rokka, Johanna, Stephanie, Fiedler, Haggarty, Stephen J, Wang, Changning, 2019
盐霉素类似物的分离及抑制吲哚胺2，3-双加氧酶活性研究, 郑城, 王涛, 谢昌贤, 云喜报, 卢晓霞, 2019
Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities, Wen, Yongju, Zhou, Zongyuan, Zhang, Guolin, Lu, Xiaoxia, 2018
Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethyl-2,3-dehydrosilybin from silybin and their antitumor activities, Yongju Wen, Zongyuan Zhou, Guolin Zhang, Xiaoxia Lu, 2018
脂肪酶催化吉法酯的合成研究, 王涛, 熊峰, 赵澜宁, 卢晓霞, 2018
具抗病毒黄精寡糖核心片段的分离纯化与四糖结构, 万振江, 潘伟, 卢晓霞, 2017
σ1受体配体的合成及其生物活性, 张琪, 赵澜宁, 潘伟, 王涛, 卢晓霞, 2017
Isolation, identification and characterization of potential impurities of anidulafungin, Zhao, Lanning, Wang, Qilong, Bie, Yi, Lu, Xiaoxia, 2017
Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids, Lan, Jianyong, Xie, Haisheng, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huanfeng, Zeng, Wei, 2017
Copper-Catalyzed Addition of Alkylboranes to Iminoacetates: Access to alpha-Alkyl Branched alpha-Amino Acids, Xiao, Xinsheng, Zhang, Wei, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huangfeng, Zeng, Wei, 2016
Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated C-sp(3)-H Bonds, Liu, Jianzhong, Xie, Ying, Zeng, Wei, Lin, Dongen, Deng, Yuanfu, Lu, Xiaoxia, 2015
炔醛参与的直接Mannich反应, 黄涌澜, 董理进, 王超, 卢晓霞, 孙健, 2013
Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of alpha-Imino Esters with Dienes, Zhu, Shujie, Lu, Xiaoxia, Luo, Yueting, Zhang, Wei, Jiang, Huanfeng, Yan, Ming, Zeng, Wei, 2013
Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of r?Imino Esters with Dienes, 卢晓霞, 2013
Palladium-Catalyzed Cascade Oxidation/sp(2) C-H Acylation of Azoarenes with Aryl Methanes, Xiong, Feng, Qian, Cheng, Lin, Dongen, Zeng, Wei, Lu, Xiaoxia, 2013
Pd-Catalyzed Tand

Organic Chemistry Medicinal Chemistry Natural Medicines Glycochemistry Molecular Targeted Drugs Synthesis Inhibitors Pharmacology Biochemistry Drug Design

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