Professor | Ming-Yuan Su | Asia Growth Partners

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Name	Ming-Yuan Su
Contact Information	sumy@sustech.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Ming-Yuan Su

Contact Information

sumy@sustech.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2012-08 to 2015-08, PhD in Biochemical Science, National Taiwan University 2010-08 to 2012-07, Master's in Biochemical Science, National Taiwan University 2005-08 to 2009-07, Bachelor's in Chemistry, National Taiwan University
Work Experience	2022-06 to present, Southern University of Science and Technology, Associate Professor 2021-05 to 2022-05, Southern University of Science and Technology, Assistant Professor 2016-08 to 2021-03, University of California, Berkeley/Lawrence Berkeley National Lab, Postdoctoral Researcher 2015-09 to 2016-07, Academia Sinica, Postdoctoral Researcher
Awards	2019-2021: AFTD Basic Science Postdoctoral Fellowship 2016-2017: Academia Sinica Postdoctoral Research Fellowship 2012-2014: Macau Postgraduate Scholarship 2011, 2013: National Taiwan University Outstanding Overseas Student Scholarship 2012: National Taiwan University College of Life Science Dean's Award 2005-2009: Macau Education and Youth Affairs Bureau College Scholarship

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2012-08 to 2015-08, PhD in Biochemical Science, National Taiwan University
2010-08 to 2012-07, Master's in Biochemical Science, National Taiwan University
2005-08 to 2009-07, Bachelor's in Chemistry, National Taiwan University

Work Experience

2022-06 to present, Southern University of Science and Technology, Associate Professor
2021-05 to 2022-05, Southern University of Science and Technology, Assistant Professor
2016-08 to 2021-03, University of California, Berkeley/Lawrence Berkeley National Lab, Postdoctoral Researcher
2015-09 to 2016-07, Academia Sinica, Postdoctoral Researcher

Awards

2019-2021: AFTD Basic Science Postdoctoral Fellowship
2016-2017: Academia Sinica Postdoctoral Research Fellowship
2012-2014: Macau Postgraduate Scholarship
2011, 2013: National Taiwan University Outstanding Overseas Student Scholarship
2012: National Taiwan University College of Life Science Dean's Award
2005-2009: Macau Education and Youth Affairs Bureau College Scholarship

Areas of Focus	Lysosomal function research including cell autophagy, mTORC1, and lysosomal signaling pathways related to disease mechanisms
Publications	Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation, Ming Liu, Yang Wang, Fei Teng, Xinyi Mai, Xi Wang, Ming-Yuan Su & Goran Stjepanovic, 2023 Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme, Fei Teng, Yang Wang, Ming Liu, Shuyun Tian, Goran Stjepanovic & Ming-Yuan Su, 2023 Structural basis for the ARF GAP activity and specificity of the C9orf72 complex, Su M-Y, Fromm SA, Remis J, Toso DB, Hurley JH, 2021 Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD, Su M-Y, Fromm SA, Zoncu R, Hurley JH, 2020 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019 How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019 Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex, Su M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH, 2017 Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc, Su M-Y, Som N, Wu C-Y, Su S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I, 2017 Structural Insights into the Allosteric Operation of the Lon AAA+ Protease, Lin C-C, Su S-C, Su M-Y, Liang P-H, Feng C-C, Wu S-H, Chang C-I, 2016 Structure of yeast Ape1 and its role in autophagic vesicle formation, Su M-Y, Peng W-H, Ho M-R, Su S-C, Chang Y-C, Chen G-C, Chang C-I, 2015 Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1, Chao S-W, Su M-Y, Chiou L-C, Chen L-C, Chang C-I, Huang W-J, 2015 1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD, Su M-Y, Chang C-I, Chang C-F, 2013 Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue, Su M-Y, Kuo C-I, Chang C-F, Chang C-I, 2013

Areas of Focus

Lysosomal function research including cell autophagy, mTORC1, and lysosomal signaling pathways related to disease mechanisms

Publications

Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation, Ming Liu, Yang Wang, Fei Teng, Xinyi Mai, Xi Wang, Ming-Yuan Su & Goran Stjepanovic, 2023
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme, Fei Teng, Yang Wang, Ming Liu, Shuyun Tian, Goran Stjepanovic & Ming-Yuan Su, 2023
Structural basis for the ARF GAP activity and specificity of the C9orf72 complex, Su M-Y, Fromm SA, Remis J, Toso DB, Hurley JH, 2021
Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD, Su M-Y, Fromm SA, Zoncu R, Hurley JH, 2020
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019
How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019
Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex, Su M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH, 2017
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc, Su M-Y, Som N, Wu C-Y, Su S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I, 2017
Structural Insights into the Allosteric Operation of the Lon AAA+ Protease, Lin C-C, Su S-C, Su M-Y, Liang P-H, Feng C-C, Wu S-H, Chang C-I, 2016
Structure of yeast Ape1 and its role in autophagic vesicle formation, Su M-Y, Peng W-H, Ho M-R, Su S-C, Chang Y-C, Chen G-C, Chang C-I, 2015
Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1, Chao S-W, Su M-Y, Chiou L-C, Chen L-C, Chang C-I, Huang W-J, 2015
1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD, Su M-Y, Chang C-I, Chang C-F, 2013
Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue, Su M-Y, Kuo C-I, Chang C-F, Chang C-I, 2013

Lysosomal Function Cell Autophagy Mtorc1 Lysosomal Signaling Disease Mechanisms Structural Biology Biochemistry Cell Biology Mass Spectrometry Drug Design

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