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Ming-Yuan Su
Medical School
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Lysosomal Function
Cell Autophagy
Mtorc1
Lysosomal Signaling
Disease Mechanisms
Structural Biology
Biochemistry
Cell Biology
Mass Spectrometry
Drug Design
Areas of Focus
- Lysosomal function research including cell autophagy, mTORC1, and lysosomal signaling pathways related to disease mechanisms
Work Experience
- 2022-06 to present, Southern University of Science and Technology, Associate Professor
- 2021-05 to 2022-05, Southern University of Science and Technology, Assistant Professor
- 2016-08 to 2021-03, University of California, Berkeley/Lawrence Berkeley National Lab, Postdoctoral Researcher
- 2015-09 to 2016-07, Academia Sinica, Postdoctoral Researcher
Academic Background & Achievements
- 2012-08 to 2015-08, PhD in Biochemical Science, National Taiwan University
- 2010-08 to 2012-07, Master's in Biochemical Science, National Taiwan University
- 2005-08 to 2009-07, Bachelor's in Chemistry, National Taiwan University
Publications
- Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation, Ming Liu, Yang Wang, Fei Teng, Xinyi Mai, Xi Wang, Ming-Yuan Su & Goran Stjepanovic, 2023
- Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme, Fei Teng, Yang Wang, Ming Liu, Shuyun Tian, Goran Stjepanovic & Ming-Yuan Su, 2023
- Structural basis for the ARF GAP activity and specificity of the C9orf72 complex, Su M-Y, Fromm SA, Remis J, Toso DB, Hurley JH, 2021
- Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD, Su M-Y, Fromm SA, Zoncu R, Hurley JH, 2020
- FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, GamperA, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019
- How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, Turco E, Witt M, Abert C, Bock-Bierbaum T, Su M-Y, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S, 2019
- Hybrid Structure of the RagA/CRagulator mTORC1 Activation Complex, Su M-Y, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH, 2017
- Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc, Su M-Y, Som N, Wu C-Y, Su S-C, Kuo Y-T, Ke L-C, Ho M-R, Tzeng S-R, Teng C-H, Mengin-Lecreulx D, Reddy M, Chang C-I, 2017
- Structural Insights into the Allosteric Operation of the Lon AAA+ Protease, Lin C-C, Su S-C, Su M-Y, Liang P-H, Feng C-C, Wu S-H, Chang C-I, 2016
- Structure of yeast Ape1 and its role in autophagic vesicle formation, Su M-Y, Peng W-H, Ho M-R, Su S-C, Chang Y-C, Chen G-C, Chang C-I, 2015
- Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1, Chao S-W, Su M-Y, Chiou L-C, Chen L-C, Chang C-I, Huang W-J, 2015
- 1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD, Su M-Y, Chang C-I, Chang C-F, 2013
- Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue, Su M-Y, Kuo C-I, Chang C-F, Chang C-I, 2013
Awards
- 2019-2021: AFTD Basic Science Postdoctoral Fellowship
- 2016-2017: Academia Sinica Postdoctoral Research Fellowship
- 2012-2014: Macau Postgraduate Scholarship
- 2011, 2013: National Taiwan University Outstanding Overseas Student Scholarship
- 2012: National Taiwan University College of Life Science Dean's Award
- 2005-2009: Macau Education and Youth Affairs Bureau College Scholarship
