2004-04--2008-08 PhD: University of Guelph, Department of Molecular and Cellular Biology
2000-09--2003-08 Master's: Tianjin University of Science and Technology, Department of Bioengineering
1996-09--2000-08 Bachelor's: Tianjin University of Science and Technology, Department of Bioengineering
2017-01~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
2013-01~2016-12 - Institute of Nutrition, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher
2009-03~2013-01 - Whitaker Cardiovascular Institute, Boston University - Postdoctoral Fellow
2008-09~2009-02 - University of Guelph, Department of Molecular and Cellular Biology - Postdoctoral Fellow
2004-07~2008-04 - University of Guelph, Department of Molecular and Cellular Biology - Teaching Assistant
Chinese Medical Association Medical Science and Technology Award (2023): Third Prize
Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (2023): Second Prize
Sichuan Provincial Science and Technology Progress Award (2022): Second Prize
Chinese Medical Association Medical Science and Technology Award (2019): Third Prize
Research
Pathology and Pathophysiology - Nutrient Sensing and Metabolic Regulation Physiology - Nutrient Sensing and Metabolic Regulation
Macrophage CREBZF orchestrates inflammatory response to potentiate insulin resistance and type 2 diabetes, Liu Y#, Su W#, Liu Z#, Hu Z, Shen J, Zheng Z, Ding D, Huang W, Li W, Cai G, Wei S, Li N, Fang X, Li H, Qin J, Zhang H, Xiao Y, Bi Y, Cui A*, Zhang C*, Li Y*, 2024
Glucose regulation of adipose tissue browning by CBP/p300 and HDAC3-mediated reversible acetylation of CREBZF, Cui A#, Xue Y#, Su W#, Lin J, Liu Y, Cai G, Wan Q, Jiang Y, Ding D, Zheng Z, Wei S, Li W, Shen J, Wen J, Huang M, Zhao J, Zhang X, Zhao Y, Li H, Ying H, Zhang H, Bi Y, Chen Y, Xu A, Xu Y*, Li Y*, 2024
Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism, Xue Y#, Cui A#, Wei S, Ma F, Liu Z, Fang X, Huo S, Sun X, Li W, Hu Z, Liu Y, Cai G, Su W, Zhao J, Yan X, Gao C, Wen J, Zhang H, Li H, Liu Y, Lin X, Xu Y, Fu W*, Fang J*, Li Y*, 2023
Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression, Ma F, Liu Y, Hu Z, Xue Y, Liu Z, Cai G, Su W, Zheng Z, Fang Z, Yan X, Ding D, Sun X, Jiang Y, Wei S, Li W, Zhao J, Zhang H, Li H, Xiao D, Zhang C, Ying H, Qin J, Gao X, Dai X, Fu W, Xu Y*, Li Y*, Cui A*, 2023
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic Sirtuin 1-C/EBP��-miRNA-223 axis, Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B*, Wang H*, 2022
MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM, Not mentioned, 2022
Emerging Roles of Selenium on Metabolism and Type 2 Diabetes, Zhao J#, Zou H#, Huo Y, Wei X, Li Y*, 2022
Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs, Not mentioned, 2022
Ginsenoside Rb1 improves metabolic disorder in high-fat diet-induced obese mice associated with modulation of gut microbiota, Zou H, Zhang M, Zhu X, Zhu L, Chen S, Luo M, Xie Q, Chen Y, Zhang K, Bu Q, Wei Y, Ye T, Li Q, Yan X, Zhou Z, Yang C, Li Y, Zhou H*, Zhang C*, You X*, Zheng G*, Zhao G*, 2022
Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors, Cui A, Ding D, Li Y*, 2021
Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene, Zhao Z, Wang Z, Zhou D, Han Y, Ma F, Hu Z, Xin F, Liu XL, Ren T, Zhang F, Xue Y, Cui A, Liu Z, Bai J, Liu Y, Cai G, Su W, Dai X, Shen F, Pan Q, Li Y*, Fan J*, 2021
Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis, Hou X, Yin S, Ren R, Liu S, Yong L, Liu L, Li Y, Zheng M, Kunos G, Gao B, Wang H*, 2021
The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18 (Pten) and independent of daf-16, Shi D#, Xia X#, Cui A#, Xiong Z, Yan Y, Luo J, Chen G, Zeng Y, Cai D, Hou L, McDermott J, Li Y, Zhang H, Han J*, 2020
The effects of B1344, a novel fibroblast growth factor 21 analog, on nonalcoholic steatohepatitis in nonhuman primates, Cui A#, Li J#, Ji S#, Ma F, Wang G, Xue Y, Liu Z, Gao J, Han J, Tai P, Wang T, Chen J, Ma X*, Li Y*, 2020
Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways, Li M, He X, Guo W, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H*, 2020
CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mice., Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*, 2020
Thrombospondin1 improves hepatic steatosis in diet-induced insulin-resistant mice and are associated with hepatic fat content in humans, Bai J, Xia M, Xue Y, Ma F, Cui A, Sun Y, Han Y, Xu X, Zhang F, Hu Z, Liu Z, Liu Y, Cai G, Su W, Sun X, Wu H, Yan H, Chang X, Hu X, Bian H, Xia P, Gao J, Li Y*, Gao X*, 2020
Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals, Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*, 2019
碱性亮氨酸拉链转录因子CREBZF通过STAT3通路调控肝脏组织再生, Not mentioned, 2019
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3, Not mentioned, 2019
The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3, Not mentioned, 2019
The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex, Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*, 2019
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway, Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X, 2019
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats, Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*, 2019
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene, Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*, 2019
Area of Focus
Protein Homeostasis | Health | Disease | Ubiquitination | Protein Degradation | Cancer Therapy | Protein Stability | Aging | Neurodegenerative Diseases | Cellular Mechanisms
