Areas of Focus
- Pathology and Pathophysiology - Nutrient Sensing and Metabolic Regulation
- Physiology - Nutrient Sensing and Metabolic Regulation
Work Experience
- 2017-01~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
- 2013-01~2016-12 - Institute of Nutrition, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Researcher
- 2009-03~2013-01 - Whitaker Cardiovascular Institute, Boston University - Postdoctoral Fellow
- 2008-09~2009-02 - University of Guelph, Department of Molecular and Cellular Biology - Postdoctoral Fellow
- 2004-07~2008-04 - University of Guelph, Department of Molecular and Cellular Biology - Teaching Assistant
Academic Background & Achievements
- 2004-04--2008-08 PhD: University of Guelph, Department of Molecular and Cellular Biology
- 2000-09--2003-08 Master's: Tianjin University of Science and Technology, Department of Bioengineering
- 1996-09--2000-08 Bachelor's: Tianjin University of Science and Technology, Department of Bioengineering
Publications
- Macrophage CREBZF orchestrates inflammatory response to potentiate insulin resistance and type 2 diabetes, Liu Y#, Su W#, Liu Z#, Hu Z, Shen J, Zheng Z, Ding D, Huang W, Li W, Cai G, Wei S, Li N, Fang X, Li H, Qin J, Zhang H, Xiao Y, Bi Y, Cui A*, Zhang C*, Li Y*, 2024
- Glucose regulation of adipose tissue browning by CBP/p300 and HDAC3-mediated reversible acetylation of CREBZF, Cui A#, Xue Y#, Su W#, Lin J, Liu Y, Cai G, Wan Q, Jiang Y, Ding D, Zheng Z, Wei S, Li W, Shen J, Wen J, Huang M, Zhao J, Zhang X, Zhao Y, Li H, Ying H, Zhang H, Bi Y, Chen Y, Xu A, Xu Y*, Li Y*, 2024
- Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism, Xue Y#, Cui A#, Wei S, Ma F, Liu Z, Fang X, Huo S, Sun X, Li W, Hu Z, Liu Y, Cai G, Su W, Zhao J, Yan X, Gao C, Wen J, Zhang H, Li H, Liu Y, Lin X, Xu Y, Fu W*, Fang J*, Li Y*, 2023
- Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression, Ma F, Liu Y, Hu Z, Xue Y, Liu Z, Cai G, Su W, Zheng Z, Fang Z, Yan X, Ding D, Sun X, Jiang Y, Wei S, Li W, Zhao J, Zhang H, Li H, Xiao D, Zhang C, Ying H, Qin J, Gao X, Dai X, Fu W, Xu Y*, Li Y*, Cui A*, 2023
- Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic Sirtuin 1-C/EBP��-miRNA-223 axis, Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B*, Wang H*, 2022
- MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM, Not mentioned, 2022
- Emerging Roles of Selenium on Metabolism and Type 2 Diabetes, Zhao J#, Zou H#, Huo Y, Wei X, Li Y*, 2022
- Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs, Not mentioned, 2022
- Ginsenoside Rb1 improves metabolic disorder in high-fat diet-induced obese mice associated with modulation of gut microbiota, Zou H, Zhang M, Zhu X, Zhu L, Chen S, Luo M, Xie Q, Chen Y, Zhang K, Bu Q, Wei Y, Ye T, Li Q, Yan X, Zhou Z, Yang C, Li Y, Zhou H*, Zhang C*, You X*, Zheng G*, Zhao G*, 2022
- Regulation of hepatic metabolism and cell growth by the ATF/CREB family of transcription factors, Cui A, Ding D, Li Y*, 2021
- CREB/ATF碱性亮氨酸拉链转录因子在代谢和细胞生长中的生物学功能, 刘雨笑， 苏维彤， 李于*, 2021
- Sodium butyrate supplementation inhibits hepatic steatosis by stimulating liver kinase B1 and insulin-induced gene, Zhao Z, Wang Z, Zhou D, Han Y, Ma F, Hu Z, Xin F, Liu XL, Ren T, Zhang F, Xue Y, Cui A, Liu Z, Bai J, Liu Y, Cai G, Su W, Dai X, Shen F, Pan Q, Li Y*, Fan J*, 2021
- Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis, Hou X, Yin S, Ren R, Liu S, Yong L, Liu L, Li Y, Zheng M, Kunos G, Gao B, Wang H*, 2021
- The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18 (Pten) and independent of daf-16, Shi D#, Xia X#, Cui A#, Xiong Z, Yan Y, Luo J, Chen G, Zeng Y, Cai D, Hou L, McDermott J, Li Y, Zhang H, Han J*, 2020
- The effects of B1344, a novel fibroblast growth factor 21 analog, on nonalcoholic steatohepatitis in nonhuman primates, Cui A#, Li J#, Ji S#, Ma F, Wang G, Xue Y, Liu Z, Gao J, Han J, Tai P, Wang T, Chen J, Ma X*, Li Y*, 2020
- Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways, Li M, He X, Guo W, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H*, 2020
- CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mice., Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*, 2020
- Thrombospondin1 improves hepatic steatosis in diet-induced insulin-resistant mice and are associated with hepatic fat content in humans, Bai J, Xia M, Xue Y, Ma F, Cui A, Sun Y, Han Y, Xu X, Zhang F, Hu Z, Liu Z, Liu Y, Cai G, Su W, Sun X, Wu H, Yan H, Chang X, Hu X, Bian H, Xia P, Gao J, Li Y*, Gao X*, 2020
- Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals, Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*, 2019
- 碱性亮氨酸拉链转录因子CREBZF通过STAT3通路调控肝脏组织再生, Not mentioned, 2019
- Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3, Not mentioned, 2019
- The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3, Not mentioned, 2019
- The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex, Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*, 2019
- Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway, Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X, 2019
- Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats, Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*, 2019
- Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene, Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*, 2019
Awards
- Chinese Medical Association Medical Science and Technology Award (2023): Third Prize
- Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (2023): Second Prize
- Sichuan Provincial Science and Technology Progress Award (2022): Second Prize
- Chinese Medical Association Medical Science and Technology Award (2019): Third Prize
