Professor | Jia Li | Asia Growth Partners

Name	Jia Li
Contact Information	jli@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Jia Li

Contact Information

jli@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1994-09--2000-06 Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1988-09--1992-06 Bachelor's: Zhejiang Medical University
Work Experience	2019-02~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Director 2013-12~2019-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Deputy Director 2010-09~2013-12 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Director 2006-07~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Doctoral Supervisor 1994-09~2000-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Graduate/Ph.D. 1988-09~1992-06 - Zhejiang Medical University - Undergraduate
Awards	2023: Pudong New Area Pearl Leading Talent 2017: Third Batch of National 'Ten Thousand Talents Program' Technology Innovation Leading Talent 2016: Shanghai Leading Talent 2016: National Young and Middle-aged Technology Innovation Leading Talent 2014: National Hundred, Thousand, and Ten Thousand Talent Project 2012: Eleventh Chinese Academy of Sciences Outstanding Youth, First Prize 2011: Shanghai Pharmaceutical Science and Technology Award, First Prize 2011: Twelfth China Youth Science and Technology Award 2011: Sanofi-Aventis—Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award Fund 2003: National Science and Technology Progress Award, Second Prize 2002: Shanghai Science and Technology Progress Award, First Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1994-09--2000-06 Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1988-09--1992-06 Bachelor's: Zhejiang Medical University

Work Experience

2019-02~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Director
2013-12~2019-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Deputy Director
2010-09~2013-12 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Director
2006-07~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Doctoral Supervisor
1994-09~2000-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Graduate/Ph.D.
1988-09~1992-06 - Zhejiang Medical University - Undergraduate

Awards

2023: Pudong New Area Pearl Leading Talent
2017: Third Batch of National 'Ten Thousand Talents Program' Technology Innovation Leading Talent
2016: Shanghai Leading Talent
2016: National Young and Middle-aged Technology Innovation Leading Talent
2014: National Hundred, Thousand, and Ten Thousand Talent Project
2012: Eleventh Chinese Academy of Sciences Outstanding Youth, First Prize
2011: Shanghai Pharmaceutical Science and Technology Award, First Prize
2011: Twelfth China Youth Science and Technology Award
2011: Sanofi-Aventis—Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award Fund
2003: National Science and Technology Progress Award, Second Prize
2002: Shanghai Science and Technology Progress Award, First Prize

Areas of Focus	Molecular Pharmacology Traditional Chinese Medicine Pharmacology
Publications	Nuclear Translocation Mechanism of Transcription Factors, Jia Li, 2023 Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, Jia Li, 2023 Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, Jia Li, 2023 The Application of APEX/APEX2-Based Proximity Labeling in MP Research, Jia Li, 2023 Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis., Jia Li, 2023 Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons., Jia Li, 2023 Targeting C/EBPβ overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia., Jia Li, 2023 Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15., Jia Li, 2023 Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer., Jia Li, 2023 生物医药那片海, Jia Li, 2022 Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia., Jia Li, 2022 Discovery of a Potent and Selective Degrader for USP7., Jia Li, 2022 Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGFβ signaling., Jia Li, 2022 Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex., Jia Li, 2022 Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis., Jia Li, 2022 Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy., Jia Li, 2022 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, Jia Li, 2021 Synthesis of 2-ethoxycarbonylthieno2,3-bquinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B, Jia Li, 2021 Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, Jia Li, 2021 SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Jia Li, 2021 Fluorescent probes for the imaging of lipid droplets in live cells, Jia Li, 2021 Guaianolide sesquiterpene lactones from Achillea millefolium L, Jia Li, 2021 Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, Jia Li, 2021 新型含咔唑环和芳环/芳稠杂环的N-酰腙衍生物的合成及蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性评价, Jia Li, 2021 Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects, Jia Li, 2021 新型含咔唑环芳氨基乙酰腙衍生物的合成及其蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性评价, Jia Li, 2021 Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity, Jia Li, 2021 Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice, Jia Li, 2021 Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, Jia Li, 2021 Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors, Jia Li, 2021 Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2, Jia Li, 2021 Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, Jia Li, 2021 Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, Jia Li, 2021 Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia, Jia Li, 2021 Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening, Jia Li, 2021 Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, Jia Li, 2021 Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening, Jia Li, 2021 Development of peptide epoxyketones as selective

Areas of Focus

Molecular Pharmacology
Traditional Chinese Medicine Pharmacology

Publications

Nuclear Translocation Mechanism of Transcription Factors, Jia Li, 2023
Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, Jia Li, 2023
Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, Jia Li, 2023
The Application of APEX/APEX2-Based Proximity Labeling in MP Research, Jia Li, 2023
Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis., Jia Li, 2023
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons., Jia Li, 2023
Targeting C/EBPβ overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia., Jia Li, 2023
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15., Jia Li, 2023
Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer., Jia Li, 2023
生物医药那片海, Jia Li, 2022
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia., Jia Li, 2022
Discovery of a Potent and Selective Degrader for USP7., Jia Li, 2022
Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGFβ signaling., Jia Li, 2022
Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex., Jia Li, 2022
Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis., Jia Li, 2022
Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy., Jia Li, 2022
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, Jia Li, 2021
Synthesis of 2-ethoxycarbonylthieno2,3-bquinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B, Jia Li, 2021
Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, Jia Li, 2021
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Jia Li, 2021
Fluorescent probes for the imaging of lipid droplets in live cells, Jia Li, 2021
Guaianolide sesquiterpene lactones from Achillea millefolium L, Jia Li, 2021
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, Jia Li, 2021
新型含咔唑环和芳环/芳稠杂环的N-酰腙衍生物的合成及蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性评价, Jia Li, 2021
Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects, Jia Li, 2021
新型含咔唑环芳氨基乙酰腙衍生物的合成及其蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性评价, Jia Li, 2021
Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity, Jia Li, 2021
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice, Jia Li, 2021
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, Jia Li, 2021
Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors, Jia Li, 2021
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2, Jia Li, 2021
Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, Jia Li, 2021
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, Jia Li, 2021
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia, Jia Li, 2021
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening, Jia Li, 2021
Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, Jia Li, 2021
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening, Jia Li, 2021
Development of peptide epoxyketones as selective

Molecular Pharmacology Drug Discovery Signal Transduction Receptor Pharmacology Cell Signaling Pharmacodynamics Pharmacokinetics Biochemical Pharmacology Pharmacogenomics Pharmacovigilance

Hongbing Shu - Wuhan University

Yong Ran - University of Chinese Academy of Sciences

Yu-Bo Zhou - University of Chinese Academy of Sciences

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