Areas of Focus
- Pharmacokinetics
- Traditional Chinese Medicine
- Herbal Medicine
- Drug Metabolism
- Clinical Pharmacology
- Toxicology
- Analytical Chemistry
- New Drug Development
- Herb-Drug Interactions
- Quality Control of Herbal Medicines
Work Experience
- 2000-12 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
- 1998-05 to 2000-11 - Rutgers University, New Jersey - Postdoctoral Researcher
- 1986-08 to 1995-03 - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences - Assistant Researcher
Academic Background & Achievements
- 1995-05 to 1998-04 Ph.D.: Tokyo University of Pharmacy and Life Sciences
- 1982-09 to 1986-07 Bachelor's Degree: Chengdu University of Traditional Chinese Medicine
Publications
- Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation, Li Chuan, 2024
- Novel assays for quality evaluation of XueBiJing: quality variability of a Chinese herbal injection for sepsis management, Li Chuan, 2022
- High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care, Li Chuan, 2019
- Glycyrrhizin has a high likelihood to be a victim of drug interactions mediated by hepatic OATP1B1/1B3, Li Chuan, 2018
- Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management, Li Chuan, 2018
- 中药多成分药代动力学研究：思路与方法, 李川, 2017
- Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine, Li Chuan, 2016
- Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats, Li Chuan, 2016
- Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen), Li Chuan, 2015
- Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs, Li Chuan, 2015
- Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions, Li Chuan, 2015
- Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3, Li Chuan, 2015
- Mass Spectrometry Imaging: Applications in Drug Distribution Studies, Li Chuan, 2015
- Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different administration routes., Li Chuan, 2013
- Combinatorial Metabolism Notably Affects Human Systemic Exposure to Ginsenosides from Orally Administered Extract of Panax notoginseng Roots (Sanqi), Li Chuan, 2013
- Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian), Li Chuan, 2013
- Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves, Li Chuan, 2012
- Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?, Li Chuan, 2012
- Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement, Li Chuan, 2012
- Editorial: absorption, disposition, and pharmacokinetics of herbal medicines: what and how?, Li Chuan, 2012
- Metabolic capabilities of cytochrome P450s in Chinese liver microsomes compared with those in Caucasian liver microsomes., Li Chuan, 2012
- Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases, Li Chuan, 2011
- Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D-1 and antagonist at D-2 receptors, in rats, Li Chuan, 2009
- Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats, Li Chuan, 2009
- 1,4-Diamino-2,3-dicyano-1,4- bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase., Li Chuan, 2009
- Pulse gradient, large-volume injection, high-throughput ultra-performance liquid chromatographic/tandem mass spectrometry bioanalysis for measurement of plasma amrubicin and its metabolite amrubicinol, Li Chuan, 2008
- Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers, Li Chuan, 2008
- Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine, Li Chuan, 2008
- Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: Ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity, Li Chuan, 2008
- Comparative metabolic capabilities and inhibitor profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17., Li Chuan, 2007
- Simultaneous quantification of multiple licorice flavonoids in rat plasma, Li Chuan, 2007
- “LC-electrolyte effects” improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting drug discovery pharmacokinetic study., Li Chuan, 2007
- Design and synthesis of novel bis( l-amino acid) ester prodrugs of 9-2-(phosphonomethoxy)ethyladenine (PMEA) with improved anti-HBV activity, Li Chuan, 2007
- A sensitive method for the detection and quantification of ginkgo flavonols from plasma, Li Chuan, 2007
- Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma, Li Chuan, 2006
- Study of inhibition of six new drugs on five human cytochrome P450 isozymes in vitro system., Li Chuan, 2006
- Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang, Li Chuan, 2006
Awards
- Second Prize (2022): Research and Industrialization of Thrombotic Injection (Freeze-dried)
- First Prize (2015): Secondary Development of Ginkgolide and Artificial Musk
- Institute Award (2014): Tang's Traditional Chinese Medicine Development Award (Young Researcher Award)
- First Prize (2010): Research and Application of Key Technologies for New Drug Discovery and Evaluation of Traditional Chinese Medicine for Metabolic Diseases
- First Prize (2008): WuXi AppTec Life Chemistry Research Award
- Third Prize (2007): Discovery of Electrolyte Effects in Liquid Chromatography and Methodological Research on Multi-component Analysis of Traditional Chinese Medicine Using LC-MS
