Professor | Li Chuan | Asia Growth Partners

Name	Li Chuan
Contact Information	chli@simm.ac.cn
Language ability	Chinese, English, Japanese
Province	Shanghai

Name

Li Chuan

Contact Information

chli@simm.ac.cn

Language ability

Chinese, English, Japanese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1995-05 to 1998-04 Ph.D.: Tokyo University of Pharmacy and Life Sciences 1982-09 to 1986-07 Bachelor's Degree: Chengdu University of Traditional Chinese Medicine
Work Experience	2000-12 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader 1998-05 to 2000-11 - Rutgers University, New Jersey - Postdoctoral Researcher 1986-08 to 1995-03 - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences - Assistant Researcher
Awards	Second Prize (2022): Research and Industrialization of Thrombotic Injection (Freeze-dried) First Prize (2015): Secondary Development of Ginkgolide and Artificial Musk Institute Award (2014): Tang's Traditional Chinese Medicine Development Award (Young Researcher Award) First Prize (2010): Research and Application of Key Technologies for New Drug Discovery and Evaluation of Traditional Chinese Medicine for Metabolic Diseases First Prize (2008): WuXi AppTec Life Chemistry Research Award Third Prize (2007): Discovery of Electrolyte Effects in Liquid Chromatography and Methodological Research on Multi-component Analysis of Traditional Chinese Medicine Using LC-MS

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1995-05 to 1998-04 Ph.D.: Tokyo University of Pharmacy and Life Sciences
1982-09 to 1986-07 Bachelor's Degree: Chengdu University of Traditional Chinese Medicine

Work Experience

2000-12 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
1998-05 to 2000-11 - Rutgers University, New Jersey - Postdoctoral Researcher
1986-08 to 1995-03 - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences - Assistant Researcher

Awards

Second Prize (2022): Research and Industrialization of Thrombotic Injection (Freeze-dried)
First Prize (2015): Secondary Development of Ginkgolide and Artificial Musk
Institute Award (2014): Tang's Traditional Chinese Medicine Development Award (Young Researcher Award)
First Prize (2010): Research and Application of Key Technologies for New Drug Discovery and Evaluation of Traditional Chinese Medicine for Metabolic Diseases
First Prize (2008): WuXi AppTec Life Chemistry Research Award
Third Prize (2007): Discovery of Electrolyte Effects in Liquid Chromatography and Methodological Research on Multi-component Analysis of Traditional Chinese Medicine Using LC-MS

Areas of Focus	Pharmacokinetics Traditional Chinese Medicine Herbal Medicine Drug Metabolism Clinical Pharmacology Toxicology Analytical Chemistry New Drug Development Herb-Drug Interactions Quality Control of Herbal Medicines
Publications	Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation, Li Chuan, 2024 Novel assays for quality evaluation of XueBiJing: quality variability of a Chinese herbal injection for sepsis management, Li Chuan, 2022 High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care, Li Chuan, 2019 Glycyrrhizin has a high likelihood to be a victim of drug interactions mediated by hepatic OATP1B1/1B3, Li Chuan, 2018 Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management, Li Chuan, 2018 中药多成分药代动力学研究：思路与方法, 李川, 2017 Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine, Li Chuan, 2016 Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats, Li Chuan, 2016 Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen), Li Chuan, 2015 Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs, Li Chuan, 2015 Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions, Li Chuan, 2015 Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3, Li Chuan, 2015 Mass Spectrometry Imaging: Applications in Drug Distribution Studies, Li Chuan, 2015 Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different administration routes., Li Chuan, 2013 Combinatorial Metabolism Notably Affects Human Systemic Exposure to Ginsenosides from Orally Administered Extract of Panax notoginseng Roots (Sanqi), Li Chuan, 2013 Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian), Li Chuan, 2013 Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves, Li Chuan, 2012 Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?, Li Chuan, 2012 Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement, Li Chuan, 2012 Editorial: absorption, disposition, and pharmacokinetics of herbal medicines: what and how?, Li Chuan, 2012 Metabolic capabilities of cytochrome P450s in Chinese liver microsomes compared with those in Caucasian liver microsomes., Li Chuan, 2012 Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases, Li Chuan, 2011 Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D-1 and antagonist at D-2 receptors, in rats, Li Chuan, 2009 Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats, Li Chuan, 2009 1,4-Diamino-2,3-dicyano-1,4- bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase., Li Chuan, 2009 Pulse gradient, large-volume injection, high-throughput ultra-performance liquid chromatographic/tandem mass spectrometry bioanalysis for measurement of plasma amrubicin and its metabolite amrubicinol, Li Chuan, 2008 Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers, Li Chuan, 2008 Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine, Li Chuan, 2008 Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: Ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity, Li Chuan, 2008 Comparative metabolic capabilities and inhibitor profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17., Li Chuan, 2007 Simultaneous quantification of multiple licorice flavonoids in rat plasma, Li Chuan, 2007 “LC-electrolyte effects” improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting drug discovery pharmacokinetic study., Li Chuan, 2007 Design and synthesis of novel bis( l-amino acid) ester prodrugs of 9-2-(phosphonomethoxy)ethyladenine (PMEA) with improved anti-HBV activity, Li Chuan, 2007 A sensitive method for the detection and quantification of ginkgo flavonols from plasma, Li Chuan, 2007 Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma, Li Chuan, 2006 Study of inhibition of six new drugs on five human cytochrome P450 isozymes in vitro system., Li Chuan, 2006 Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang, Li Chuan, 2006

Areas of Focus

Pharmacokinetics
Traditional Chinese Medicine
Herbal Medicine
Drug Metabolism
Clinical Pharmacology
Toxicology
Analytical Chemistry
New Drug Development
Herb-Drug Interactions
Quality Control of Herbal Medicines

Publications

Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation, Li Chuan, 2024
Novel assays for quality evaluation of XueBiJing: quality variability of a Chinese herbal injection for sepsis management, Li Chuan, 2022
High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care, Li Chuan, 2019
Glycyrrhizin has a high likelihood to be a victim of drug interactions mediated by hepatic OATP1B1/1B3, Li Chuan, 2018
Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management, Li Chuan, 2018
中药多成分药代动力学研究：思路与方法, 李川, 2017
Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine, Li Chuan, 2016
Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats, Li Chuan, 2016
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen), Li Chuan, 2015
Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs, Li Chuan, 2015
Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions, Li Chuan, 2015
Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3, Li Chuan, 2015
Mass Spectrometry Imaging: Applications in Drug Distribution Studies, Li Chuan, 2015
Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different administration routes., Li Chuan, 2013
Combinatorial Metabolism Notably Affects Human Systemic Exposure to Ginsenosides from Orally Administered Extract of Panax notoginseng Roots (Sanqi), Li Chuan, 2013
Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian), Li Chuan, 2013
Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves, Li Chuan, 2012
Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?, Li Chuan, 2012
Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement, Li Chuan, 2012
Editorial: absorption, disposition, and pharmacokinetics of herbal medicines: what and how?, Li Chuan, 2012
Metabolic capabilities of cytochrome P450s in Chinese liver microsomes compared with those in Caucasian liver microsomes., Li Chuan, 2012
Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases, Li Chuan, 2011
Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D-1 and antagonist at D-2 receptors, in rats, Li Chuan, 2009
Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats, Li Chuan, 2009
1,4-Diamino-2,3-dicyano-1,4- bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase., Li Chuan, 2009
Pulse gradient, large-volume injection, high-throughput ultra-performance liquid chromatographic/tandem mass spectrometry bioanalysis for measurement of plasma amrubicin and its metabolite amrubicinol, Li Chuan, 2008
Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers, Li Chuan, 2008
Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine, Li Chuan, 2008
Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: Ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity, Li Chuan, 2008
Comparative metabolic capabilities and inhibitor profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17., Li Chuan, 2007
Simultaneous quantification of multiple licorice flavonoids in rat plasma, Li Chuan, 2007
“LC-electrolyte effects” improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting drug discovery pharmacokinetic study., Li Chuan, 2007
Design and synthesis of novel bis( l-amino acid) ester prodrugs of 9-2-(phosphonomethoxy)ethyladenine (PMEA) with improved anti-HBV activity, Li Chuan, 2007
A sensitive method for the detection and quantification of ginkgo flavonols from plasma, Li Chuan, 2007
Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma, Li Chuan, 2006
Study of inhibition of six new drugs on five human cytochrome P450 isozymes in vitro system., Li Chuan, 2006
Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang, Li Chuan, 2006

Pharmacokinetics Traditional Chinese Medicine Herbal Medicine Drug Metabolism Clinical Pharmacology Toxicology Analytical Chemistry New Drug Development Herb-Drug Interactions Quality Control

Jiang Yue - Wuhan University

Shuhong Guan - University of Chinese Academy of Sciences

Min Lei - University of Chinese Academy of Sciences

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