Areas of Focus
- Immunotherapy
- Directed Molecular Evolution
- Protein Thermodynamics
- Immunologic Synapse
Work Experience
- 2012.10 — Present - Researcher (Part-time) - National Key Laboratory of Respiratory Diseases, Guangzhou Medical University/CAS Guangzhou Institutes of Biomedicine and Health; President, Joint Laboratory of Health Institute/Xiangxue Pharmaceuticals, Guangzhou
- 2011.12 — Present - Researcher (National Distinguished Expert, Guangdong Leading Talent) - CAS Guangzhou Institutes of Biomedicine and Health, Guangzhou
- 2011.01—2011.11 - Director, Protein Technology - Immunocore Ltd, Oxford, UK
- 2006.01—2010.12 - Director, Protein Engineering - Avidex Ltd, Oxford, UK
- 2003.07—2005.12 - Manager, Protein Engineering - Avidex Ltd, Oxford, UK
- 2002.07—2003.06 - Senior Researcher (Biotechnology) - Avidex Ltd, Oxford, UK
- 2000.12—2002.05 - Research Manager (Antibody Engineering) - Biovation Ltd / Merck KgaA, Cambridge, UK
- 2000.06—2000.11 - Senior Researcher (Biotechnology) - ADAS Ltd, University of Leicester, Department of Biology
- 1997.01—2000.06 - Researcher (Biotechnology) - ADAS Ltd, University of Leicester, Department of Biology
Academic Background & Achievements
- 1996.01—1997.01 Postdoctoral (Immunobiotechnology): University of Leicester, Department of Biology
- 1992.10-1995.12 PhD (Antibody Engineering): University of Leicester, Department of Biology
- 1982.10 – 1987.06 Bachelor's (Medicine): Hunan Medical University, Department of Medicine
Publications
- Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors., Zhang H, Zhang J, Chen L, Weng Z, Tian Y, Zhao H, Li Y, Chen L, Liang Z, Zheng H, Zhao W, Zhong S, Li Y., 2016
- Monoclonal TCR-redirected tumour cell killing., Liddy, N., Bossi, G., Adams, K. J., Lissina, A., Mahon, T. M., Hassan, N. J., Gavarret, J., Bianchi, F. C., Pumphrey, N. J., Ladell, K., Gostick, E., Sewell, A. K., Lissin, N. M., Harwood, N. E., Molloy, P. E., Li, Y., Cameron, B. J., Sami, M., Baston, E. E., Todorov, P. T., Paston, S. J., Dennis, R. E., Harper, J. V., Dunn, S. M., Ashfield, R., Johnson, A., McGrath, Y., Plesa, G., June, C. H., Kalos, M., Price, D. A., Vuidepot, A., Williams, D. D., Sutton, D. H., Jakobsen. B. K., 2012
- T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions., Cole DK, Miles KM, Madura F, Holland CJ, Schauenburg AJ, Godkin AJ, Bulek AM, Fuller A, Akpovwa HJ, Pymm PG, Liddy N, Sami M, Li Y, Rizkallah PJ, Jakobsen BK, Sewell AK, 2014
- Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode., Cole DK, Sami M, Scott DR, Rizkallah PJ, Borbulevych OY, Todorov PT, Moysey RK, Jakobsen BK, Boulter JM, Baker BM, Yi Li., 2013
- Directed evolution of human T-cell receptors with picomolar affinities by phage display., Li, Y., Moysey, R., Molloy, P. E., Vuidepot, A. L., Mahon, T., Baston, E., Dunn, S., Liddy, N., Jacob, J., Jakobsen, B. K. & Boulter, J. M., 2005
- Control of HIV-1 immune escape by CD8 T-cells expressing enhanced T-cell receptor., Varela-Rohena, A., Molloy, P.E., Dunn, S.M., Li, Y., Suhoski, M.M., Carroll, R.G., Milicic, A., Mahon, T., Sutton, D.H., Lauge, B.E., Moysey, R., Cameron, B.J. Vuidepot, A., Purbhoo, M.E., Cole, D.K. Phillips, R.E., June, C.H., Jakobsen, B.K., Sewell, A.K., Riley, J.L., 2008
- The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor., Purbhoo*, M. A.; Li*, Y.; Sutton*, D. H.; Brewer, J. E.; Gostick, E.; Bossi, G.; Laugel, B.; Moysey, R.; Baston, E.; Liddy, N.; Cameron, B.; Bennett, A. D.; Ashfield, R.; Milicic, A.; Price, D. A.; Classon, B. J.; Sewell, A. K.; Jakobsen, B. K., 2007
