Professor | Lei Li | Asia Growth Partners

Name	Lei Li
Contact Information	lil@ioz.ac.cn
Language ability	Chinese, English, Japanese
Province	Beijing

Name

Lei Li

Contact Information

lil@ioz.ac.cn

Language ability

Chinese, English, Japanese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1999-04 to 2002-03 PhD: Gunma University, Japan 1990-09 to 1994-06 Bachelor's Degree: China Agricultural University
Work Experience	2009-05 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher 2003-10 to 2009-05 - National Institutes of Health, USA - Visiting/Research Fellow 2002-04 to 2003-10 - Institute for Molecular and Cellular Regulation, Gunma University, Japan - Foreign Researcher 1998-05 to 1999-03 - Institute for Molecular and Cellular Regulation, Gunma University, Japan - Trainee 1994-07 to 1997-08 - Jiangxi Mingxing Enterprise Group - Engineer
Awards	NIH Fellow Award for Research Excellence (2008) NIDDK Nancy Nossal Fellowship Award (2007) NIH Fellow Award for Research Excellence (2005)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1999-04 to 2002-03 PhD: Gunma University, Japan
1990-09 to 1994-06 Bachelor's Degree: China Agricultural University

Work Experience

2009-05 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
2003-10 to 2009-05 - National Institutes of Health, USA - Visiting/Research Fellow
2002-04 to 2003-10 - Institute for Molecular and Cellular Regulation, Gunma University, Japan - Foreign Researcher
1998-05 to 1999-03 - Institute for Molecular and Cellular Regulation, Gunma University, Japan - Trainee
1994-07 to 1997-08 - Jiangxi Mingxing Enterprise Group - Engineer

Awards

NIH Fellow Award for Research Excellence (2008)
NIDDK Nancy Nossal Fellowship Award (2007)
NIH Fellow Award for Research Excellence (2005)

Areas of Focus	Basic Medicine
Publications	Structural basis of the subcortical maternal complex and its implications in reproductive disorders., Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D., 2024 Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation., Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W, Li L., 2023 Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition., Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F, Li L., 2022 Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and pre-implantation development., Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L, Xie W., 2022 In vitro investigation of mammalian early embryonic development (in Chinese)., Wang Z, Zhang J, Li L., 2022 In vitro investigation of mammalian peri-implantation embryogenesis., Quan Y, Wang X, Li L., 2022 BCAS2 is involved in alternative splicing and mouse oocyte development., Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L., 2022 Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese)., Wang X, Lu X, Xiang Y, Li L., 2021 Formative pluripotent stem cells show features of epiblast cells poised for gastrulation., Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L., 2021 Stabilizing formative pluripotent states with germ cell competency., Shyn-Chang N and Li L., 2021 Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation'., Ma H, Wang H, Zheng P, Li L., 2020 Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency., Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W., 2020 In vitro culture of cynomolgus monkey embryos beyond early gastrulation., Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P, Li L, Wang H., 2019 The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution., Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L., 2019 Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4., Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X., 2019 Putting stem cells on a low-fat diet switches their pluripotent state., Jiang Z, Guang L, Li L, Shyh-Chang N., 2019 Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation., Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY., 2019 An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese)., Wang X, Qin D, Lu X, Li L., 2018 Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs., Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q., 2018 Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis., Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z, Li L., 2018 Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles., Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L., 2018 ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast., Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z, Li L., 2018 Dynamic epigenomic landscapes during early lineage specification., Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W., 2018 A maternal functional module in the mammalian oocyte-to-embryo transition., Lu X, Gao Z, Qin D, Li L., 2017 MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production., Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S., 2017 First cell lineage specification in mammalian early development (in Chinese)., Nie X, Lu X, Li L., 2017 BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis., Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S, Yi Z, Li L., 2017 Trp-Asp (WD) repeat domain 1 is essential for mouse peri-implantation development and regulates Cofilin phosphorylation., Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L., 2017 BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis., Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L., 2016 MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2., Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q, Li L., 2016 Maternal BCAS2 protects genomic integrity in mouse early embryonic development., Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S, Li L., 2015 The roles of ERAS during cell lineage specification of mouse early embryonic development., Zhao Z, Yu Y, Ma H, Wang X, Lu X, Zhai Y, Zhang X, Wang H, Li L., 2015 Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability., Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P., 2015 Identification of a human subcortical maternal complex., Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L., 2015 The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics., Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J, Li L., 2014 Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -

Areas of Focus

Basic Medicine

Publications

Structural basis of the subcortical maternal complex and its implications in reproductive disorders., Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D., 2024
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation., Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W, Li L., 2023
Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition., Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F, Li L., 2022
Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and pre-implantation development., Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L, Xie W., 2022
In vitro investigation of mammalian early embryonic development (in Chinese)., Wang Z, Zhang J, Li L., 2022
In vitro investigation of mammalian peri-implantation embryogenesis., Quan Y, Wang X, Li L., 2022
BCAS2 is involved in alternative splicing and mouse oocyte development., Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L., 2022
Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese)., Wang X, Lu X, Xiang Y, Li L., 2021
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation., Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L., 2021
Stabilizing formative pluripotent states with germ cell competency., Shyn-Chang N and Li L., 2021
Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation'., Ma H, Wang H, Zheng P, Li L., 2020
Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency., Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W., 2020
In vitro culture of cynomolgus monkey embryos beyond early gastrulation., Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P, Li L, Wang H., 2019
The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution., Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L., 2019
Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4., Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X., 2019
Putting stem cells on a low-fat diet switches their pluripotent state., Jiang Z, Guang L, Li L, Shyh-Chang N., 2019
Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation., Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY., 2019
An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese)., Wang X, Qin D, Lu X, Li L., 2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs., Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q., 2018
Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis., Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z, Li L., 2018
Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles., Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L., 2018
ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast., Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z, Li L., 2018
Dynamic epigenomic landscapes during early lineage specification., Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W., 2018
A maternal functional module in the mammalian oocyte-to-embryo transition., Lu X, Gao Z, Qin D, Li L., 2017
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production., Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S., 2017
First cell lineage specification in mammalian early development (in Chinese)., Nie X, Lu X, Li L., 2017
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis., Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S, Yi Z, Li L., 2017
Trp-Asp (WD) repeat domain 1 is essential for mouse peri-implantation development and regulates Cofilin phosphorylation., Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L., 2017
BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis., Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L., 2016
MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2., Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q, Li L., 2016
Maternal BCAS2 protects genomic integrity in mouse early embryonic development., Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S, Li L., 2015
The roles of ERAS during cell lineage specification of mouse early embryonic development., Zhao Z, Yu Y, Ma H, Wang X, Lu X, Zhai Y, Zhang X, Wang H, Li L., 2015
Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability., Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P., 2015
Identification of a human subcortical maternal complex., Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L., 2015
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics., Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J, Li L., 2014
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -

Medicine Biology Embryology Development Stem Cells Genetics Reproduction Molecular Biology Cell Biology Biomedical Research

Guoan Chen - Southern University of Science and Technology

Jin Tang Dong - Southern University of Science and Technology

Wanqiu Li - Southern University of Science and Technology

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