Areas of Focus
- Design, synthesis, and screening of DNA-encoded compound libraries targeting specific targets
- Development of chemical reactions compatible with nucleic acids for DNA-encoded compound library synthesis
- Design and synthesis of multifunctional small molecule drugs
- Selective chemical modification of macromolecules
Work Experience
- 2017.7-Present - Shanghai Institute of Materia Medica - Group Leader, Researcher
- 2016.5-2017.6 - GlaxoSmithKline, Boston, USA - Associate Fellow
- 2010.11-2016.5 - GlaxoSmithKline, Boston, USA - Researcher
Academic Background & Achievements
- 2007.9-2011.5 Ph.D. in Organic Chemistry: Brandeis University
- 2005.9-2007.8 M.Sc. in Organic Chemistry: Brandeis University
- 2001.9-2005.6 B.Sc. in Chemistry: Nanjing University
Publications
- On-DNA Pd and Cu promoted C-N Cross-Coupling Reactions, Xiaojie Lu, Sarah Roberts, George J. Frankline, Christopher P. Davie, 2017
- Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis, Xiaojie Lu, Lijun Fan, Christopher B. Phelps, Christopher P. Davie, Christine P. Donahue, 2017
- Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis, Baptiste Thomas, Xiaojie Lu, William Birmingham, Kun Huang, Peter Both, Juana Reyes Martinez, Robert Young, Christopher Davie, Sabine Flitsch, 2017
- Hydrogen Bonding-Mediated Cooperative Organocataoysis by Modified Cinchona Alkaloids, Xiaojie Lu, Li Deng, 2015
- Catalytic Enantioselective Peroxidation of α,β-Unsaturated Aldehydes for the Asymmetric Synthesis of Biologically Important Chiral Endoperoxides, Lin Hu, Xiaojie Lu, Li Deng, 2015
- Catalytic Asymmetric Peroxidation of α,β-Unsaturated Nitroalkenes by a Bifunctional Organic catalyst, Xiaojie Lu, Li Deng, 2014
- Catalytic enantioselective peroxidation of a,b-unsaturated ketones, Xiaojie Lu, Yan Liu, Bingfeng Sun, Brittany Cindric, Li Deng, 2008
- Asymmetric aza-Michael reactions of a,b-unsaturated ketones with bifunctional organic catalysts, Xiaojie Lu, Li Deng, 2008
- Enantioselective Diels-Alder reaction of simple a,b-unsaturated ketones with a Cinchona Alkaloid catalyst, Ravi P. Singh, Keith Bartelson, Yi Wang, Heng Su, Xiaojie Lu, Li Deng, 2008
Awards
- 2017: Youth Award from the Organization Department
