Professor | Shibing Tang | Asia Growth Partners

Name	Shibing Tang
Contact Information	tang_shibing@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Shibing Tang

Contact Information

tang_shibing@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2002-2006 Bachelor: Jilin University, College of Chemistry 2006-2011 Doctorate: Lanzhou University, College of Chemistry and Chemical Engineering, State Key Laboratory of Functional Organic Molecules
Work Experience	2011-2017 - University of California, San Francisco - Postdoctoral Researcher 2017-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Principal Investigator, Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2002-2006 Bachelor: Jilin University, College of Chemistry
2006-2011 Doctorate: Lanzhou University, College of Chemistry and Chemical Engineering, State Key Laboratory of Functional Organic Molecules

Work Experience

2011-2017 - University of California, San Francisco - Postdoctoral Researcher
2017-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Principal Investigator, Researcher

Areas of Focus	Drug development for malignant tumors and metabolic diseases Design, synthesis, and application of bioactive tool molecules Synthesis strategies and process optimization for small molecule drugs
Publications	Synthesis of STM2457, a selective small-molecule inhibitor of METTL3, Zhu C, Liu J, Ni Y, Chen W, Rong W, Zhang X, Guo C, Kong X, Tang S, 2024 Practical synthesis of epocholeone, a plant growth-promoting steroid with long-lasting activity, Tian J, Lin Y, Han J, Tang S, 2024 Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells, Wu T, Li ST, Ran Y, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B, Tang S, 2023 SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation, Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X, 2021 The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis, Liu X, Zhang Y, Chu Y, Zhao X, Mao L, Zhao S, Lin S, Hui X, Gu P, Xu Y, Loomes K, Tang S, Nie T, Wu D, 2021 Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation, Tan J, Liu H, Huang M, Li N, Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S, 2020 Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T, 2019 Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway, Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S, Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T, 2019 A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease, Hou L, Yang G, Tang S, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF, 2018 Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease, Qin Y, Tang S, Zhen G, Ding Q, Ding S, Cao X, 2018 Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions, Yang B, Tang S, Ma C, Li ST, Shang GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L, 2017 Pharmacological reprogramming of somatic cells for regenerative medicine, Xie M, Tang S, Li K, Ding S, 2017 Chemical enhancement of in vitro and in vivo direct cardiac reprogramming, Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D, 2017 Brown adipogenic reprogramming induced by a small molecule, Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S, 2017 Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of Retinitis Pigmentosa, Nakamura PA, Shimchuk AA, Tang S, Wang Z, Degolier K, Ding S, Reh TA, 2017 Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa, Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA, 2016 Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery, Tang S, Xie M, Cao N, Ding S, 2016 Human pancreatic beta-like cells converted from fibroblasts, Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S, 2016 Chemical approaches to cell reprogramming, Yu C, Liu K, Tang S, Ding S, 2014 Total syntheses of Tardioxopiperazine A, Isoechinulin A, and Variecolorin C, Dai Q, Xie X, Xu S, Ma D, Tang S, She X, 2011 Concise total syntheses of (+)-strictifolione and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one, Tang S, Xie X, Wang X, He L, Xu K, She X, 2010 Stereoselective syntheses of four diastereomers of 3,9,12-trihydroxycalamenene via a benzobicyclo[3.3.1] intermediate, Sun Y, Yu B, Wang X, Tang S, She X, Pan X, 2010 Asymmetric total synthesis of (-)-Cladospolide B, Wang W, Zhang J, He J, Tang S, Wang X, She X, Pan X, 2008 Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols, Tang S, He J, Sun Y, He L, She X, 2010 Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts, He J, Tang S, Tang S, Liu J, Sun Y, Pan X, She X, 2009 Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles, Tang S, He J, Sun Y, He L, She X, 2009

Areas of Focus

Drug development for malignant tumors and metabolic diseases
Design, synthesis, and application of bioactive tool molecules
Synthesis strategies and process optimization for small molecule drugs

Publications

Synthesis of STM2457, a selective small-molecule inhibitor of METTL3, Zhu C, Liu J, Ni Y, Chen W, Rong W, Zhang X, Guo C, Kong X, Tang S, 2024
Practical synthesis of epocholeone, a plant growth-promoting steroid with long-lasting activity, Tian J, Lin Y, Han J, Tang S, 2024
Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells, Wu T, Li ST, Ran Y, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B, Tang S, 2023
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation, Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X, 2021
The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis, Liu X, Zhang Y, Chu Y, Zhao X, Mao L, Zhao S, Lin S, Hui X, Gu P, Xu Y, Loomes K, Tang S, Nie T, Wu D, 2021
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation, Tan J, Liu H, Huang M, Li N, Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S, 2020
Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T, 2019
Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway, Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S, Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T, 2019
A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease, Hou L, Yang G, Tang S, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF, 2018
Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease, Qin Y, Tang S, Zhen G, Ding Q, Ding S, Cao X, 2018
Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions, Yang B, Tang S, Ma C, Li ST, Shang GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L, 2017
Pharmacological reprogramming of somatic cells for regenerative medicine, Xie M, Tang S, Li K, Ding S, 2017
Chemical enhancement of in vitro and in vivo direct cardiac reprogramming, Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D, 2017
Brown adipogenic reprogramming induced by a small molecule, Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S, 2017
Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of Retinitis Pigmentosa, Nakamura PA, Shimchuk AA, Tang S, Wang Z, Degolier K, Ding S, Reh TA, 2017
Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa, Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA, 2016
Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery, Tang S, Xie M, Cao N, Ding S, 2016
Human pancreatic beta-like cells converted from fibroblasts, Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S, 2016
Chemical approaches to cell reprogramming, Yu C, Liu K, Tang S, Ding S, 2014
Total syntheses of Tardioxopiperazine A, Isoechinulin A, and Variecolorin C, Dai Q, Xie X, Xu S, Ma D, Tang S, She X, 2011
Concise total syntheses of (+)-strictifolione and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one, Tang S, Xie X, Wang X, He L, Xu K, She X, 2010
Stereoselective syntheses of four diastereomers of 3,9,12-trihydroxycalamenene via a benzobicyclo[3.3.1] intermediate, Sun Y, Yu B, Wang X, Tang S, She X, Pan X, 2010
Asymmetric total synthesis of (-)-Cladospolide B, Wang W, Zhang J, He J, Tang S, Wang X, She X, Pan X, 2008
Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols, Tang S, He J, Sun Y, He L, She X, 2010
Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts, He J, Tang S, Tang S, Liu J, Sun Y, Pan X, She X, 2009
Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles, Tang S, He J, Sun Y, He L, She X, 2009

Malignant Tumors Metabolic Diseases Drug Development Bioactive Molecules Tool Molecules Synthesis Process Optimization Small Molecule Drugs Preclinical Research Innovative Drug Discovery

Yuewei Guo - University of Chinese Academy of Sciences

Ji Yanxiao - Wuhan University

Pengfei Xu - Wuhan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us