Professor | Pengfei Xu | Asia Growth Partners

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Name	Pengfei Xu
Contact Information	pengfeixu@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Pengfei Xu

Contact Information

pengfeixu@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2012/09-2017/07: PhD in Physiology, Beijing Normal University 2007/09-2012/07: Bachelor in Veterinary Medicine, Northwest A&F University Published over 20 SCI papers with 2600+ citations Holds 2 national invention patents
Work Experience	2023/03-Present: Professor, School of Pharmaceutical Sciences, Wuhan University 2022/02-2023/02: Lecturer, Department of Pharmaceutical Sciences, University of Pittsburgh 2018/01-2022/01: Postdoctoral Researcher, School of Pharmacy, University of Pittsburgh

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2012/09-2017/07: PhD in Physiology, Beijing Normal University
2007/09-2012/07: Bachelor in Veterinary Medicine, Northwest A&F University
Published over 20 SCI papers with 2600+ citations
Holds 2 national invention patents

Work Experience

2023/03-Present: Professor, School of Pharmaceutical Sciences, Wuhan University
2022/02-2023/02: Lecturer, Department of Pharmaceutical Sciences, University of Pittsburgh
2018/01-2022/01: Postdoctoral Researcher, School of Pharmacy, University of Pittsburgh

Areas of Focus	Clinical Pharmacology - Basic research and medical translation of metabolic diseases Mechanisms of metabolic diseases involving liver and intestinal metabolism and potential therapeutic targets Development of high-throughput 3D organ-chip drug screening systems for liver and intestinal metabolic diseases
Publications	Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure, P. Xu, Y. Xi, P. Wang, Z. Luka, M. Xu, H.C. Tung, J. Wang, S. Ren, D. Feng, B.Gao, A. D. Singhi, S. P. Monga, J. D. York, X. Ma, Z. Huang, W. Xie, 2022 Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis, P. Xu, Y. Xi, J. Zhu, M. Zhang, Z. Luka, D.B. Stolz, X.Cai, Yang Xie, Meishu Xu, Songrong Ren, Zhiying Huang, Da Yang, John D. York, Xiaochao Ma, Wen Xie, 2021 Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis, P. Xu, Y. Xi, J. Kim, J. Zhu, M. Zhang, M. Xu, S. Ren, D. Yang, X. Ma, W. Xie, 2023 Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases, P. Xu, X. Cai, X. Guan, W. Xie, 2023 Nuclear Receptors in Health and Diseases, P. Xu, 2023 Environmental chemical TCPOBOP disrupts milk lipid homeostasis during pregnancy and lactation, S. Pan, Y. Guo, W. Yu, F. Hong, X. Qiao, J. Zhang, P. Xu, Y. Zhai, 2023 PPARγ is Essential in Triclosan Induced Placental Dysfunction, J. Li, X. Quan, Y. Zhang, T. Yu, S. Lei, Z. Huang, Q. Wang, W. Song, X. Yang, P. Xu, 2022 Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights, P. Ye, Y. Xi, Z. Huang, P. Xu, 2020 Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017 Melatonin prevents obesity through modulation of gut microbiota in mice, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017

Areas of Focus

Clinical Pharmacology - Basic research and medical translation of metabolic diseases
Mechanisms of metabolic diseases involving liver and intestinal metabolism and potential therapeutic targets
Development of high-throughput 3D organ-chip drug screening systems for liver and intestinal metabolic diseases

Publications

Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure, P. Xu, Y. Xi, P. Wang, Z. Luka, M. Xu, H.C. Tung, J. Wang, S. Ren, D. Feng, B.Gao, A. D. Singhi, S. P. Monga, J. D. York, X. Ma, Z. Huang, W. Xie, 2022
Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis, P. Xu, Y. Xi, J. Zhu, M. Zhang, Z. Luka, D.B. Stolz, X.Cai, Yang Xie, Meishu Xu, Songrong Ren, Zhiying Huang, Da Yang, John D. York, Xiaochao Ma, Wen Xie, 2021
Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis, P. Xu, Y. Xi, J. Kim, J. Zhu, M. Zhang, M. Xu, S. Ren, D. Yang, X. Ma, W. Xie, 2023
Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases, P. Xu, X. Cai, X. Guan, W. Xie, 2023
Nuclear Receptors in Health and Diseases, P. Xu, 2023
Environmental chemical TCPOBOP disrupts milk lipid homeostasis during pregnancy and lactation, S. Pan, Y. Guo, W. Yu, F. Hong, X. Qiao, J. Zhang, P. Xu, Y. Zhai, 2023
PPARγ is Essential in Triclosan Induced Placental Dysfunction, J. Li, X. Quan, Y. Zhang, T. Yu, S. Lei, Z. Huang, Q. Wang, W. Song, X. Yang, P. Xu, 2022
Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights, P. Ye, Y. Xi, Z. Huang, P. Xu, 2020
Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017
Melatonin prevents obesity through modulation of gut microbiota in mice, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017

Clinical Pharmacology Metabolic Diseases Medical Translation Liver Metabolism Intestinal Metabolism Therapeutic Targets High-Throughput Screening 3D Organ Chips Drug Development Disease Mechanism

Kou Hao - Wuhan University

Ji Yanxiao - Wuhan University

Lei Han - Wuhan University

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