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Pengfei Xu
Medical School
Wuhan University
Hubei
Language: English, Chinese
Clinical Pharmacology
Metabolic Diseases
Medical Translation
Liver Metabolism
Intestinal Metabolism
Therapeutic Targets
High-Throughput Screening
3D Organ Chips
Drug Development
Disease Mechanism
Areas of Focus
- Clinical Pharmacology - Basic research and medical translation of metabolic diseases
- Mechanisms of metabolic diseases involving liver and intestinal metabolism and potential therapeutic targets
- Development of high-throughput 3D organ-chip drug screening systems for liver and intestinal metabolic diseases
Work Experience
- 2023/03-Present: Professor, School of Pharmaceutical Sciences, Wuhan University
- 2022/02-2023/02: Lecturer, Department of Pharmaceutical Sciences, University of Pittsburgh
- 2018/01-2022/01: Postdoctoral Researcher, School of Pharmacy, University of Pittsburgh
Academic Background & Achievements
- 2012/09-2017/07: PhD in Physiology, Beijing Normal University
- 2007/09-2012/07: Bachelor in Veterinary Medicine, Northwest A&F University
- Published over 20 SCI papers with 2600+ citations
- Holds 2 national invention patents
Publications
- Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure, P. Xu, Y. Xi, P. Wang, Z. Luka, M. Xu, H.C. Tung, J. Wang, S. Ren, D. Feng, B.Gao, A. D. Singhi, S. P. Monga, J. D. York, X. Ma, Z. Huang, W. Xie, 2022
- Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis, P. Xu, Y. Xi, J. Zhu, M. Zhang, Z. Luka, D.B. Stolz, X.Cai, Yang Xie, Meishu Xu, Songrong Ren, Zhiying Huang, Da Yang, John D. York, Xiaochao Ma, Wen Xie, 2021
- Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis, P. Xu, Y. Xi, J. Kim, J. Zhu, M. Zhang, M. Xu, S. Ren, D. Yang, X. Ma, W. Xie, 2023
- Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases, P. Xu, X. Cai, X. Guan, W. Xie, 2023
- Nuclear Receptors in Health and Diseases, P. Xu, 2023
- Environmental chemical TCPOBOP disrupts milk lipid homeostasis during pregnancy and lactation, S. Pan, Y. Guo, W. Yu, F. Hong, X. Qiao, J. Zhang, P. Xu, Y. Zhai, 2023
- PPARγ is Essential in Triclosan Induced Placental Dysfunction, J. Li, X. Quan, Y. Zhang, T. Yu, S. Lei, Z. Huang, Q. Wang, W. Song, X. Yang, P. Xu, 2022
- Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights, P. Ye, Y. Xi, Z. Huang, P. Xu, 2020
- Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017
- Melatonin prevents obesity through modulation of gut microbiota in mice, P. Xu, J. Wang, F. Hong, S. Wang, X. Jin, T. Xue, L. Jia, Y. Zhai, 2017
