Areas of Focus
- Structure and function of membrane proteins (ion channels) and their research in natural drugs
Work Experience
- 2024-02~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher (Group Leader)
- 2020-07~2024-02 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher (Group Leader)
- 2019-01~2020-06 - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2016-03~2017-03 - Baylor College of Medicine - Postdoctoral Researcher
- 2013-11~2018-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
- 2011-05~2013-10 - Yunnan Biovalley Pharmaceutical Co., Ltd. and Kunming Institute of Botany, Chinese Academy of Sciences - Jointly Trained Postdoctoral Researcher
Academic Background & Achievements
- 2009-05--2010-04 Visiting Student: University of Illinois at Chicago
- 2005-09--2011-01 PhD: Kunming Institute of Botany, Chinese Academy of Sciences
- 2001-09--2005-07 Bachelor's Degree: Sun Yat-sen University
Publications
- Analgesic Buxus alkaloids with enhanced selectivity for the low voltage-gated calcium channel Cav3.2 over Cav3.1 through a new binding mode., Nian Yin, 2024
- Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides, Nian Yin, 2023
- Caged polycyclic polyprenylated acylphloroglucinols as Ca(v)3.2 low voltage-gated Ca2+ channel inhibitors from Hypericum curvisepalum, Nian Yin, 2022
- Icetexane diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives, Nian Yin, 2022
- Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Ca(v)3.2 channels, Nian Yin, 2022
- Discovery of novel coffee diterpenoids with inhibitions on Cav3.1 low voltage-gated Ca2+ channel, Nian Yin, 2022
- Icetexane Diterpenoids as Cav3.2 T-type calcium channel inhibitors from Salvia prattii and Analgesic Effect of Their Semi-synthesized Derivatives, Nian Yin, 2022
- New ent-kaurane diterpenes from the roasted arabica coffee beans and molecular docking to alpha-glucosidase, Nian Yin, 2021
- Scholarinine A, a N3 type caged-monoterpene indole alkaloid as Cav3.1 T-type calcium channel inhibitor from Alstonia scholaris, Nian Yin, 2020
- Structure and mechanism of human diacylglycerol O-acyltransferase 1, Nian Yin, 2020
- Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca(v)3.1 Low Voltage Gated Ca2+ Channel, Nian Yin, 2020
- Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors, Nian Yin, 2020
- Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Cav3.1 T-type calcium channel inhibitor from Hypericum henryi, Nian Yin, 2019
- Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii, Nian Yin, 2019
- Two Diterpenoids with Two Skeletons from Euphorbia peplus., Nian Yin, 2018
- Valepotriates From the Roots and Rhizomes of Valeriana jatamansi Jones as Novel N-Type Calcium Channel Antagonists, Nian Yin, 2018
- Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis, Nian Yin, 2018
- Structure of an EIIC sugar transporter trapped in an inward-facing conformation, Nian Yin, 2018
- 环阿尔廷烷型四环三萜化合物对HCT116细胞增殖、细胞周期和凋亡的影响, Nian Yin, 2018
- A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells, Nian Yin, 2017
- Ca(v)2.2 and Ca(v)3.1 calcium channel inhibitors from Valeriana jatamansi Jones, Nian Yin, 2017
- Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida, Nian Yin, 2017
- Cimifrigines A-G, Cytotoxic Triterpenes with an Oxime Group from the Flowers of Cimicifuga frigid., Nian Yin, 2017
- Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity, Nian Yin, 2016
- Cytotoxic 9,19-cycloartane triterpenoids from the roots of Cimicifuga foetida L., Nian Yin, 2016
- KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway, Nian Yin, 2016
- New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment, Nian Yin, 2016
- New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia, Nian Yin, 2015
- New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis, Nian Yin, 2015
- Four New Cucurbitacins from the Fruit of Momordica charantia, Nian Yin, 2014
- Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis, Nian Yin, 2014
- New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida, Nian Yin, 2014
- 姜酮的NMR解析, Nian Yin, 2013
- Cytotoxic Cycloartane Triterpenes of the TraditionalChinese Medicine 'Shengma' (Cimicifuga dahurica), Nian Yin, 2013
- Triterpenes from the Aerial Parts of Cimicifuga yunnanensis and Their Antiproliferative Effects on p53(N236S) Mouse Embryonic Fibroblasts, Nian Yin, 2013
- Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities, Nian Yin, 2012
- A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L, Nian Yin, 2012
- Four New 9,19-Cyclolanostane Triterpenes from the Rhizomes of Cimicifuga foetida Collected in Yulong, Nian Yin, 2012
- Cycloartane Triterpenoids from Cimicifuga yunnanensis induce Apoptosis of Breast Cancer Cells (MCF7) via p53-dependent Mitochondrial Signaling Pathway, Nian Yin, 2011
- Three New Cycloartane (= 9,19-Cyclolanostane) Glycosides from Cimicifuga foetida, Nian Yin, 2011
- Five New Triterpene Bisglycosides with Acyclic Side Chains from the Rhizomes of Cimicifuga foetida L., Nian Yin, 2010
- Trinor-cycloartane Glycosides from the Rhizomes of Cimicifuga foetida, Nian Yin, 2009
- New triterpene diglycosides from the rhizome of Cimifuga foetida, Nian Yin, 2008
- Cytotoxic Cycloartane Triterpenes of Traditional Chinese Medicine 'Shengma' (Cimicifugadahurica), Nian Yin, 2008
