Professor | Song Moshi | Asia Growth Partners

Name	Song Moshi
Contact Information	songmoshi@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

Name

Song Moshi

Contact Information

songmoshi@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2011 - Master's Degree in Medicine: Karolinska Institute, Sweden 2015 - Ph.D. in Science: Washington University in St. Louis, USA 2016-2018 - Postdoctoral Research: Stanford University, USA 2018-present - Researcher (PI): Institute of Zoology, Chinese Academy of Sciences 2018 - Selected for Chinese Academy of Sciences BR Program 2019 - National High-Level Overseas Talent Introduction Program Youth Project 2019 - National Excellent Young Scientists Fund Project 2020 - Beijing Outstanding Young Scientists Fund Project
Work Experience	2016-2018 - Stanford University - Postdoctoral Research 2018-present - Institute of Zoology, Chinese Academy of Sciences - Researcher (PI)
Awards	Beijing Science and Technology Award Natural Science Award Second Prize (2023) Chinese Medical Science and Technology Award Medical Science and Technology Award Second Prize (2021) Top Ten Advances in Chinese Science (2020) Top Ten Advances in Chinese Life Sciences (2020) Outstanding Scientific Achievement Award of the Chinese Academy of Sciences (2020)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2011 - Master's Degree in Medicine: Karolinska Institute, Sweden
2015 - Ph.D. in Science: Washington University in St. Louis, USA
2016-2018 - Postdoctoral Research: Stanford University, USA
2018-present - Researcher (PI): Institute of Zoology, Chinese Academy of Sciences
2018 - Selected for Chinese Academy of Sciences BR Program
2019 - National High-Level Overseas Talent Introduction Program Youth Project
2019 - National Excellent Young Scientists Fund Project
2020 - Beijing Outstanding Young Scientists Fund Project

Work Experience

2016-2018 - Stanford University - Postdoctoral Research
2018-present - Institute of Zoology, Chinese Academy of Sciences - Researcher (PI)

Awards

Beijing Science and Technology Award Natural Science Award Second Prize (2023)
Chinese Medical Science and Technology Award Medical Science and Technology Award Second Prize (2021)
Top Ten Advances in Chinese Science (2020)
Top Ten Advances in Chinese Life Sciences (2020)
Outstanding Scientific Achievement Award of the Chinese Academy of Sciences (2020)

Areas of Focus	Molecular mechanisms of cardiac aging and related diseases Intervention strategies for cardiac aging and related diseases
Publications	Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac injury after ischemia/reperfusion, Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J, Song M, 2024 Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury, Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J, Song M, 2024 Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract, Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F, Song M, Wang J, 2023 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis, He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH, Wang S, Song M, Qu J, 2023 Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells, Gou B, Chu X, Xiao Y, Liu P, Zhang H, Gao Z, Song M, 2022 Potential approaches for intervening aging, Shen J, Liu GH, Song M, 2022 Destabilizing heterochromatin by APOE mediates senescence, Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M, Zhang W, Qu J, Liu GH, 2022 mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells, Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH, Ma S, Qu J, Song M, 2022 Low-dose chloroquine treatment extends the lifespan of aged rats, Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH, Song M, Qu J, Zhang W, 2022 SIRT3 consolidates heterochromatin and counteracts senescence, Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH, Wang S, Song M, Qu J, 2021 Single-cell transcriptomic atlas of primate cardiopulmonary aging, Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M, Zhang W, Liu GH, 2021 FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction, Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH, Zhang W, Song M, Qu J, 2021 SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer, Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M, Liu GH, Qu J, 2020 Treating osteoarthritis via gene therapy with rejuvenation factors, Zhang J, Liu GH, Qu J, Song M, 2020 Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging, Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH, 2020 Chemical screen identifies a geroprotective role of quercetin in premature aging, Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M, Qu J, Liu GH, 2019 Mitochondrial regulation of cardiac aging, Wang Y, Li Y, He C, Gou B, Song M, 2019 CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells, Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH, Zhang W, Song M, Qu J, 2018 Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence, Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd, 2017 Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice, Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd, 2015 Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts, Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd, 2015 Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth, Song M, Matkovich SJ, Zhang Y, Hammer DJ, Dorn GW 2nd, 2015 Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart, Song M, Dorn GW 2nd, 2015 Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts, Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd, 2015 Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy, Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd, 2014

Areas of Focus

Molecular mechanisms of cardiac aging and related diseases
Intervention strategies for cardiac aging and related diseases

Publications

Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac injury after ischemia/reperfusion, Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*, 2024
Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury, Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*, 2024
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract, Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F*, Song M*, Wang J*, 2023
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis, He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*, 2023
Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells, Gou B, Chu X, Xiao Y, Liu P, Zhang H, Gao Z, Song M, 2022
Potential approaches for intervening aging, Shen J, Liu GH*, Song M*, 2022
Destabilizing heterochromatin by APOE mediates senescence, Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*, 2022
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells, Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*, 2022
Low-dose chloroquine treatment extends the lifespan of aged rats, Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*, 2022
SIRT3 consolidates heterochromatin and counteracts senescence, Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*, 2021
Single-cell transcriptomic atlas of primate cardiopulmonary aging, Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*, 2021
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction, Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*, 2021
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer, Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J*, 2020
Treating osteoarthritis via gene therapy with rejuvenation factors, Zhang J, Liu GH*, Qu J*, Song M*, 2020
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging, Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH, 2020
Chemical screen identifies a geroprotective role of quercetin in premature aging, Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M*, Qu J*, Liu GH*, 2019
Mitochondrial regulation of cardiac aging, Wang Y, Li Y, He C, Gou B, Song M, 2019
CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells, Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*, 2018
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence, Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd, 2017
Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice, Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd, 2015
Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts, Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd, 2015
Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth, Song M, Matkovich SJ, Zhang Y, Hammer DJ, Dorn GW 2nd, 2015
Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart, Song M, Dorn GW 2nd, 2015
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts, Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd, 2015
Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy, Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd, 2014

Cardiac Aging Molecular Mechanisms Related Diseases Intervention Strategies Heart Aging Disease Molecular Biology Cardiology Biomedical Research

Hai Rao - Southern University of Science and Technology

Tao Wang - University of Chinese Academy of Sciences

Xiao Yichuan - University of Chinese Academy of Sciences

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us