Areas of Focus
- New Drug Research for Diabetes and Its Complications
- New Drug Research for Chronic Inflammatory Bowel Disease
- New Drug Research for Non-Alcoholic Steatohepatitis
Work Experience
- 2000-08~2018-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 1998-09~2000-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
Academic Background & Achievements
- 1995-09--1998-07 PhD in Physics: Fudan University
Publications
- Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker, 11th Author, 2018
- Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, 11th Author, 2018
- Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects, 11th Author, 2017
- Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2, 11th Author, 2017
- Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitors as a Potential Therapy for Diabetic Macular Edema, 11th Author, 2016
- OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 6th Author, 2016
- Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, 11th Author, 2016
- Discovery of a Novel Series of Imidazo1,2-apyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors, 10th Author, 2015
- Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, 8th Author, 2015
- 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, 9th Author, 2014
- Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, 9th Author, 2013
- Design and synthesis of imidazole and triazole derivatives as Lp-PLA inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., 11th Author, 2013
- Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, 6th Author, 2013
- Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, 7th Author, 2013
- Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists, 9th Author, 2012
Awards
- Target Kinetics and Drug Design (2007): Second Prize, National Level
