Professor | Jianhua Shen | Asia Growth Partners

Name	Jianhua Shen
Contact Information	jhshen@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Jianhua Shen

Contact Information

jhshen@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1995-09--1998-07 PhD in Physics: Fudan University
Work Experience	2000-08~2018-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 1998-09~2000-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
Awards	Target Kinetics and Drug Design (2007): Second Prize, National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1995-09--1998-07 PhD in Physics: Fudan University

Work Experience

2000-08~2018-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
1998-09~2000-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher

Awards

Target Kinetics and Drug Design (2007): Second Prize, National Level

Areas of Focus	New Drug Research for Diabetes and Its Complications New Drug Research for Chronic Inflammatory Bowel Disease New Drug Research for Non-Alcoholic Steatohepatitis
Publications	Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker, 11th Author, 2018 Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, 11th Author, 2018 Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects, 11th Author, 2017 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2, 11th Author, 2017 Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitors as a Potential Therapy for Diabetic Macular Edema, 11th Author, 2016 OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 6th Author, 2016 Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, 11th Author, 2016 Discovery of a Novel Series of Imidazo1,2-apyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors, 10th Author, 2015 Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, 8th Author, 2015 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, 9th Author, 2014 Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, 9th Author, 2013 Design and synthesis of imidazole and triazole derivatives as Lp-PLA inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., 11th Author, 2013 Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, 6th Author, 2013 Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, 7th Author, 2013 Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists, 9th Author, 2012

Areas of Focus

New Drug Research for Diabetes and Its Complications
New Drug Research for Chronic Inflammatory Bowel Disease
New Drug Research for Non-Alcoholic Steatohepatitis

Publications

Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker, 11th Author, 2018
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, 11th Author, 2018
Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects, 11th Author, 2017
Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2, 11th Author, 2017
Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitors as a Potential Therapy for Diabetic Macular Edema, 11th Author, 2016
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 6th Author, 2016
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, 11th Author, 2016
Discovery of a Novel Series of Imidazo1,2-apyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors, 10th Author, 2015
Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, 8th Author, 2015
4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, 9th Author, 2014
Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, 9th Author, 2013
Design and synthesis of imidazole and triazole derivatives as Lp-PLA inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., 11th Author, 2013
Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, 6th Author, 2013
Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, 7th Author, 2013
Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists, 9th Author, 2012

Diabetes Complications New Drug Chronic Inflammatory Bowel Disease Non-Alcoholic Steatohepatitis Research Therapy

Xiaoyan Wu - Wuhan University

Yanhong Wei - Wuhan University

Min Liu - Wuhan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us