Professor | 沈建华 | 数字化转型顾问

Name	沈建华
Contact Information	jhshen@simm.ac.cn
Language ability	中文, 英文
Province	上海

Name

沈建华

Contact Information

jhshen@simm.ac.cn

Language ability

中文, 英文

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1995-09--1998-07 物理学博士学位: 复旦大学
Work Experience	2000-08~2018-06 - 中科院上海药物研究所 - 研究员 1998-09~2000-07 - 中国科学院上海药物研究所 - 博士后
Awards	靶标动力学与药物设计 (2007): 二等奖, 国家级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1995-09--1998-07 物理学博士学位: 复旦大学

Work Experience

2000-08~2018-06 - 中科院上海药物研究所 - 研究员
1998-09~2000-07 - 中国科学院上海药物研究所 - 博士后

Awards

靶标动力学与药物设计 (2007): 二等奖, 国家级

Areas of Focus	糖尿病及其并发症新药研究慢性炎症性肠炎新药研究非酒精脂肪肝炎新药研究
Publications	Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker, 第11作者, 2018 Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, 第11作者, 2018 Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects, 第11作者, 2017 Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2, 第11作者, 2017 Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitors as a Potential Therapy for Diabetic Macular Edema, 第11作者, 2016 OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 第6作者, 2016 Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, 第11作者, 2016 Discovery of a Novel Series of Imidazo1,2-apyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors, 第10作者, 2015 Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, 第8作者, 2015 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, 第9作者, 2014 Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, 第9作者, 2013 Design and synthesis of imidazole and triazole derivatives as Lp-PLA inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., 第11作者, 2013 Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, 第6作者, 2013 Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, 第7作者, 2013 Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists, 第9作者, 2012

Areas of Focus

糖尿病及其并发症新药研究
慢性炎症性肠炎新药研究
非酒精脂肪肝炎新药研究

Publications

Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker, 第11作者, 2018
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, 第11作者, 2018
Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects, 第11作者, 2017
Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2, 第11作者, 2017
Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitors as a Potential Therapy for Diabetic Macular Edema, 第11作者, 2016
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 第6作者, 2016
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, 第11作者, 2016
Discovery of a Novel Series of Imidazo1,2-apyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A(2) Inhibitors, 第10作者, 2015
Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, 第8作者, 2015
4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, 第9作者, 2014
Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, 第9作者, 2013
Design and synthesis of imidazole and triazole derivatives as Lp-PLA inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., 第11作者, 2013
Triazole derivatives: A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, 第6作者, 2013
Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, 第7作者, 2013
Design, Synthesis, and Antidiabetic Activity of 4-Phenoxynicotinamide and 4-Phenoxypyrimidine-5-carboxamide Derivatives as Potent and Orally Efficacious TGR5 Agonists, 第9作者, 2012

糖尿病并发症新药慢性炎症性肠炎非酒精性脂肪肝炎研究治疗

张冬 - 武汉大学

Area of Focus
冠状动脉 | 介入 | 慢性闭塞 | 左主干病变 | 分叉 | 钙化 | 扭曲 | 复杂 | 超声 | 旋磨 | 冠状动脉内 | 技术 | 成像 | 诊断 | 心脏 | 精确 | 评估 | 血管 | 病变 | 移除 | 设备 | 肾 | 动脉 | 支架 | 扩张术 | 肾脏 | 治疗 | 程序 | 导管插入 | 起搏器 | 高级 | 安置 | 节律 | 管理 | 并发症 | 先天性 | 疾病 | 封堵 | 封闭 | 儿科 | 心脏病学

邓浩华 - 武汉大学

Area of Focus
糖尿病 | 并发症 | 代谢 | 综合征 | 甲状腺 | 垂体 | 肾上腺 | 更年期 | 风湿 | 疾病

杨杪 - 武汉大学

Area of Focus
糖尿病 | 并发症 | 代谢 | 疾病 | 甲状腺 | 痛风 | 骨质疏松 | 内分泌 | 治疗 | 研究

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们