Advanced Worker (2024): 3rd 'Outstanding Role Model Around You' of Shanghai Branch, Chinese Academy of Sciences
Lihuayi Chemical Innovation Award (2023): 1st Chinese Chemical Society
Excellent Supervisor (2023): Chinese Academy of Sciences
Most Beautiful Science Worker in Shanghai (2022): Shanghai
Top Ten Scientific and Technological Innovations (2022): Shanghai Branch, Chinese Academy of Sciences
May Fourth Youth Commando (2021): Shanghai Branch, Chinese Academy of Sciences
State Council Special Government Allowance (2019): State Council
Outstanding Role Model Around You (2019): Shanghai Branch, Chinese Academy of Sciences
Shanghai Staff Rationalization Construction Innovation Award (2018): Shanghai
Research
Drug Chemistry Drug Synthesis Route Research
An Alternative Approach to Synthesize Sildenafil via Improved Copper-Catalyzed Cyclization, Jingshan Shen, 2024
Impurity study of tecovirimat, Jingshan Shen, 2024
An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol, Jingshan Shen, 2024
Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer, Jingshan Shen, 2024
Direct esterification of amides by the dimethylsulfate-mediated activation of amide C-N bonds, Jingshan Shen, 2024
Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models, Jingshan Shen, 2024
Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19, Jingshan Shen, 2024
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety, Jingshan Shen, 2024
Improved and ligand-free copper-catalyzed cyclization for an efficient synthesis of benzimidazoles from o-bromoarylamine and nitriles, Jingshan Shen, 2024
An efficient synthesis of the last step key intermediate for telmisartan via Pd-catalyzed carbonylative cyclization, Jingshan Shen, 2023
Optimized Synthesis of the Key Intermediate of Telmisartan via the Cyclization of 2-Bromoarylamine with n-Butyronitrile, Jingshan Shen, 2023
Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids, Jingshan Shen, 2023
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety, Jingshan Shen, 2023
Synthesis and evaluation of NHC derivatives and 4'-fluorouridine prodrugs, Jingshan Shen, 2023
Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2, Jingshan Shen, 2023
Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2, Jingshan Shen, 2023
Structure-based development and preclinical evaluation of SARS-CoV-2 3C-like protease inhibitor simnotrelvir, Jingshan Shen, 2023
Efficient Large-Scale Process for Tecovirimat via Reactive Distillation for the Preparation of Cycloheptatriene, Jingshan Shen, 2023
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir, Jingshan Shen, 2023
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial, Jingshan Shen, 2023
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, Jingshan Shen, 2023
Optimized Synthesis of a Key Intermediate of Nirmatrelvir, Jingshan Shen, 2023
TPN171片在中国老年受试者中的安全性及药动学Ⅰ期临床研究, 沈敬山, 2023
Pharmacokinetics, mass balance, and metabolism of [14C] TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension, Jingshan Shen, 2023
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog SARS-CoV-2, in Chinese healthy subjects, Jingshan Shen, 2022
Synthesis and biological evaluation of artemisinin derivatives as potential MS agents, Jingshan Shen, 2022
A novel synthesis of tetrahydrocortisone 3-glucuronide, Jingshan Shen, 2022
One-pot synthesis of molnupiravir from cytidine, Jingshan Shen, 2022
Synthesis and antiviral activity of 2'-deoxy-6'-substituted carbocyclic nucleosides, Jingshan Shen, 2022
Synthesis and biological evaluation of artemisinin derivatives as potential MS agents, Jingshan Shen, 2022
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model, Jingshan Shen, 2022
An improved and practical synthesis of rivaroxaban, Jingshan Shen, 2022
Chemo- and site-selective lysine modification of peptides and proteins under native conditions using the water-soluble zolinium, Jingshan Shen, 2022
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2, Jingshan Shen, 2021
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of TPN171H, a novel phosphodiesterase type 5 inhibitior, in healthy subjects, Jingshan Shen, 2021
Scalable Process of Making 5, 7-Dichloro-tetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group, Jingshan Shen, 2021
Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2, Jingshan Shen, 2021
TPN672: A Novel Serotonin-Dopamine Activity Modulator for the Treatment of Schizophrenia, Jingshan Shen, 2021
Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-D-N4-hydroxycytidine, Jingshan Shen, 2021
Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate, Jingshan Shen, 2021
Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus, Jingshan Shen, 2021
9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation, Jingshan Shen, 2021
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Jingshan Shen, 2021
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS, Jingshan Shen, 2021
抗新冠肺炎药物研究进展, 沈敬山, 2021
Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N-4-hydroxycytidine, Jings
Keywords
Drug ChemistryPharmaceuticalsOrganic ChemistrySynthesisMedicinal ChemistryDrug DevelopmentChemical SynthesisPharmacologyBiochemistryMolecular Biology
