Professor | Zhengli Shi | Asia Growth Partners

Name	Zhengli Shi
Contact Information	zlshi@wh.iov.cn
Language ability	Chinese, French
Province	Hubei

Name

Zhengli Shi

Contact Information

zlshi@wh.iov.cn

Language ability

Chinese, French

Province

Hubei

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1996-10--2000-05 PhD: University of Montpellier II, France 1987-09--1990-07 Master's Degree: Wuhan Institute of Virology, Chinese Academy of Sciences 1983-09--1987-07 Bachelor's Degree: Wuhan University
Work Experience	2000-10~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher 1998-07~2000-09 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher 1993-07~1998-06 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher 1990-07~1993-06 - Wuhan Institute of Virology, Chinese Academy of Sciences - Research Intern
Awards	Chinese Academy of Sciences Advanced Worker (2020): Institute Level Wuhan City Advanced Individual in Fighting COVID-19 (2020): City Level Chinese Academy of Sciences Excellent Mentor Award (2020): Institute Level Research on Important Viruses Carried by Chinese Bats (2018): National Level, Second Prize Research on Important Viruses Carried by Chinese Bats (2017): Provincial Level, First Prize Hubei Province Excellent Academic Paper in Natural Science (2014): Provincial Level, Special Prize Research on the Behavior, Evolution, and Virus Interaction of Bats (2009): Ministry Level, Second Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1996-10--2000-05 PhD: University of Montpellier II, France
1987-09--1990-07 Master's Degree: Wuhan Institute of Virology, Chinese Academy of Sciences
1983-09--1987-07 Bachelor's Degree: Wuhan University

Work Experience

2000-10~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher
1998-07~2000-09 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher
1993-07~1998-06 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher
1990-07~1993-06 - Wuhan Institute of Virology, Chinese Academy of Sciences - Research Intern

Awards

Chinese Academy of Sciences Advanced Worker (2020): Institute Level
Wuhan City Advanced Individual in Fighting COVID-19 (2020): City Level
Chinese Academy of Sciences Excellent Mentor Award (2020): Institute Level
Research on Important Viruses Carried by Chinese Bats (2018): National Level, Second Prize
Research on Important Viruses Carried by Chinese Bats (2017): Provincial Level, First Prize
Hubei Province Excellent Academic Paper in Natural Science (2014): Provincial Level, Special Prize
Research on the Behavior, Evolution, and Virus Interaction of Bats (2009): Ministry Level, Second Prize

Areas of Focus	Pathogeny of Emerging Animal Viruses Molecular Epidemiology Cross-Species Transmission Mechanism Antiviral Mechanism in Bats
Publications	The protective nasal boosting of a triple-RBD subunit vaccine against SARS-CoV-2 following inactivated virus vaccination, Yang, Jingyi, Liu, MeiQin, Liu, Lin, Li, Xian, Xu, Mengxin, Lin, Haofeng, Li, Min, Yan, Huimin, Chen, YaoQing, Shi, ZhengLi, 2023 Dynamic variations in COVID-19 with the SARS-CoV-2 Omicron variant in Kazakhstan and Pakistan, Qianqian Cui, Zhengli Shi, Duman Yimamaidi, Ben Hu, Zhuo Zhang, Muhammad Saqib, Ali Zohaib, Baikadamova Gulnara, Mukhanbetkaliyev Yersyn, Zengyun Hu, Shizhu Li, 2023 A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice, Liu, MeiQin, Lin, HaoFeng, Li, Jing, Chen, Ying, Luo, Yun, Zhang, Wei, Hu, Ben, Tian, FengJuan, Hu, YunJia, Liu, YuJie, Jiang, RenDi, Gong, QianChun, Li, Ang, Guo, ZiShuo, Li, Bei, Yang, XingLou, Tong, YiGang, Shi, ZhengLi, 2023 Strategy To Assess Zoonotic Potential Reveals Low Risk Posed by SARS-Related Coronaviruses from Bat and Pangolin, Yang, Yong, Shen, XuRui, Zhang, YuLan, Jiang, Rendi, Wang, Xi, Guan, ZhenQiong, Li, Qian, Yao, YuLin, Gong, Qianchun, Geng, Rong, Wang, Qi, Zhu, Yan, Luo, JingYi, Shi, ZhengLi, Zhang, Huilan, Peng, Ke, Zhou, Peng, 2023 Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses, Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, XingLou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, ZhengLi Shi, Jinghe Huang, 2022 Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China, Li, Yang, Si, HaoRui, Zhu, Yan, Xie, Nan, Li, Bei, Zhang, XiangPing, Han, JunFeng, Bao, HongHong, Yang, Yong, Zhao, Kai, Hou, ZiYuan, Cheng, SiJia, Zhang, ShuanHu, Shi, ZhengLi, Zhou, Peng, 2022 Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection, Zheng, XiaoShuang, Wang, Qi, Min, Juan, Shen, XuRui, Li, Qian, Zhao, QiuChen, Wang, Xi, Jiang, RenDi, Geng, Rong, Chen, Ying, Zhu, Yan, Li, Bei, Zhang, Wei, Li, Ang, Xie, TingTing, Liu, MeiQin, Cheng, Liang, Shi, ZhengLi, Zhou, Peng, 2022 Discovery of novel DNA viruses in small mammals from Kenya, Ochola, Griphin Ochieng, Li, Bei, Obanda, Vincent, Ommeh, Sheila, Ochieng, Harold, Yang, XingLou, Onyuok, Samson Omondi, Shi, ZhengLi, Agwanda, Bernard, Hu, Ben, 2022 A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration, Ma, Huan, Zhang, Xinghai, Zeng, Weihong, Zhou, Junhui, Chi, Xiangyang, Chen, Shaohong, Zheng, Peiyi, Wang, Meihua, Wu, Yan, Zhao, Dan, Gong, Fanwu, Lin, Haofeng, Sun, Hancong, Yu, Changming, Shi, Zhengli, Hu, Xiaowen, Zhang, Huajun, Jin, Tengchuan, Chiu, Sandra, 2022 ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells, Guo, Hua, Li, Ang, Dong, TianYi, Su, Jia, Yao, YuLin, Zhu, Yan, Shi, ZhengLi, Letko, Michael, 2022 Functional Peroral Infectivity Complex of White Spot Syndrome Virus of Shrimp, Wang, Xi, Chen, Cheng, Zhang, Nan, Chen, Qingxiu, Zhang, Fenghua, Liu, Xijia, Li, Fang, Shi, ZhengLi, Vlak, Just M, Wang, Manli, Hu, Zhihong, 2022 The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint, Guo, Hua, Li, Ang, Lin, HaoFeng, Liu, MeiQin, Chen, Jing, Jiang, TingTing, Li, Bei, Wang, Yi, Letko, Michael C, Peng, Wenjie, Shi, ZhengLi, 2022 Characteristics of SARS-CoV-2 and COVID-19 (vol 19, pg 141, 2021), Hu, Ben, Guo, Hua, Zhou, Peng, Shi, ZhengLi, 2022 Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice, MeiQin Liu, RenDi Jiang, Jing Guo, Ying Chen, DongSheng Yang, Xi Wang, HaoFeng Lin, Ang Li, Bei Li, Ben Hu, ZeJun Wang, XingLou Yang, ZhengLi Shi, Tom Gallagher, 2022 A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concern, Yang, Jingyi, Liu, MeiQin, Liu, Lin, Li, Xian, Xu, Mengxin, Lin, Haofeng, Liu, Shuning, Hu, Yunqi, Li, Bei, Liu, Bowen, Li, Min, Sun, Ying, Chen, YaoQing, Shi, ZhengLi, Yan, Huimin, 2022 A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunity, Li, Yang, Wang, Xi, Shen, XuRui, Geng, Rong, Xie, Nan, Han, JunFeng, Zhang, QingMiao, Shi, ZhengLi, Zhou, Peng, 2022 Lethal Swine Acute Diarrhea Syndrome Coronavirus Infection in Suckling Mice, Chen, Ying, Jiang, RenDi, Wang, Qi, Luo, Yun, Liu, MeiQin, Zhu, Yan, Liu, Xi, He, YanTong, Zhou, Peng, Yang, XingLou, Shi, ZhengLi, 2022 Broad Cell Tropism of SADS-CoV In Vitro Implies Its Potential Cross-Species Infection Risk, Luo, Yun, Chen, Ying, Geng, Rong, Li, Bei, Chen, Jing, Zhao, Kai, Zheng, XiaoShuang, Zhang, Wei, Zhou, Peng, Yang, XingLou, Shi, ZhengLi, 2021 Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates, Yao, YanFeng, Wang, ZeJun, Jiang, RenDi, Hu, Xue, Zhang, HuaJun, Zhou, YiWu, Gao, Ge, Chen, Ying, Peng, Yun, Liu, MeiQin, Zhang, YaNan, Min, Juan, Lu, Jia, Gao, XiaoXiao, Guo, Jing, Peng, Cheng, Shen, XuRui, Li, Qian, Zhao, Kai, Yang, Lian, Wan, Xin, Zhang, Bo, Wang, WenHui, Wu, Jia, Zhou, Peng, Yang, XingLou, Shen, Shuo, Shan, Chao, Yuan, ZhiMing, Shi, ZhengLi, 2021 Characterization of Novel Rhabdoviruses in Chinese Bats, Luo, DongSheng, Li, Bei, Shen, XuRui, Jiang, RenDi, Zhu, Yan, Wu, Jia, Fan, Yi, Bourhy, Herve, Hu, Ben, Ge, XingYi, Shi, ZhengLi, Dache

Areas of Focus

Pathogeny of Emerging Animal Viruses
Molecular Epidemiology
Cross-Species Transmission Mechanism
Antiviral Mechanism in Bats

Publications

The protective nasal boosting of a triple-RBD subunit vaccine against SARS-CoV-2 following inactivated virus vaccination, Yang, Jingyi, Liu, MeiQin, Liu, Lin, Li, Xian, Xu, Mengxin, Lin, Haofeng, Li, Min, Yan, Huimin, Chen, YaoQing, Shi, ZhengLi, 2023
Dynamic variations in COVID-19 with the SARS-CoV-2 Omicron variant in Kazakhstan and Pakistan, Qianqian Cui, Zhengli Shi, Duman Yimamaidi, Ben Hu, Zhuo Zhang, Muhammad Saqib, Ali Zohaib, Baikadamova Gulnara, Mukhanbetkaliyev Yersyn, Zengyun Hu, Shizhu Li, 2023
A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice, Liu, MeiQin, Lin, HaoFeng, Li, Jing, Chen, Ying, Luo, Yun, Zhang, Wei, Hu, Ben, Tian, FengJuan, Hu, YunJia, Liu, YuJie, Jiang, RenDi, Gong, QianChun, Li, Ang, Guo, ZiShuo, Li, Bei, Yang, XingLou, Tong, YiGang, Shi, ZhengLi, 2023
Strategy To Assess Zoonotic Potential Reveals Low Risk Posed by SARS-Related Coronaviruses from Bat and Pangolin, Yang, Yong, Shen, XuRui, Zhang, YuLan, Jiang, Rendi, Wang, Xi, Guan, ZhenQiong, Li, Qian, Yao, YuLin, Gong, Qianchun, Geng, Rong, Wang, Qi, Zhu, Yan, Luo, JingYi, Shi, ZhengLi, Zhang, Huilan, Peng, Ke, Zhou, Peng, 2023
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses, Yingdan Wang, Meiqin Liu, Yaping Shen, Yunping Ma, Xiang Li, Yuanyuan Zhang, Mei Liu, XingLou Yang, Jun Chen, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu, Yumei Wen, Shibo Jiang, Fan Wu, Qiang Zhou, ZhengLi Shi, Jinghe Huang, 2022
Characteristics of SARS-CoV-2 transmission in a medium-sized city with traditional communities during the early COVID-19 epidemic in China, Li, Yang, Si, HaoRui, Zhu, Yan, Xie, Nan, Li, Bei, Zhang, XiangPing, Han, JunFeng, Bao, HongHong, Yang, Yong, Zhao, Kai, Hou, ZiYuan, Cheng, SiJia, Zhang, ShuanHu, Shi, ZhengLi, Zhou, Peng, 2022
Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection, Zheng, XiaoShuang, Wang, Qi, Min, Juan, Shen, XuRui, Li, Qian, Zhao, QiuChen, Wang, Xi, Jiang, RenDi, Geng, Rong, Chen, Ying, Zhu, Yan, Li, Bei, Zhang, Wei, Li, Ang, Xie, TingTing, Liu, MeiQin, Cheng, Liang, Shi, ZhengLi, Zhou, Peng, 2022
Discovery of novel DNA viruses in small mammals from Kenya, Ochola, Griphin Ochieng, Li, Bei, Obanda, Vincent, Ommeh, Sheila, Ochieng, Harold, Yang, XingLou, Onyuok, Samson Omondi, Shi, ZhengLi, Agwanda, Bernard, Hu, Ben, 2022
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration, Ma, Huan, Zhang, Xinghai, Zeng, Weihong, Zhou, Junhui, Chi, Xiangyang, Chen, Shaohong, Zheng, Peiyi, Wang, Meihua, Wu, Yan, Zhao, Dan, Gong, Fanwu, Lin, Haofeng, Sun, Hancong, Yu, Changming, Shi, Zhengli, Hu, Xiaowen, Zhang, Huajun, Jin, Tengchuan, Chiu, Sandra, 2022
ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells, Guo, Hua, Li, Ang, Dong, TianYi, Su, Jia, Yao, YuLin, Zhu, Yan, Shi, ZhengLi, Letko, Michael, 2022
Functional Peroral Infectivity Complex of White Spot Syndrome Virus of Shrimp, Wang, Xi, Chen, Cheng, Zhang, Nan, Chen, Qingxiu, Zhang, Fenghua, Liu, Xijia, Li, Fang, Shi, ZhengLi, Vlak, Just M, Wang, Manli, Hu, Zhihong, 2022
The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint, Guo, Hua, Li, Ang, Lin, HaoFeng, Liu, MeiQin, Chen, Jing, Jiang, TingTing, Li, Bei, Wang, Yi, Letko, Michael C, Peng, Wenjie, Shi, ZhengLi, 2022
Characteristics of SARS-CoV-2 and COVID-19 (vol 19, pg 141, 2021), Hu, Ben, Guo, Hua, Zhou, Peng, Shi, ZhengLi, 2022
Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice, MeiQin Liu, RenDi Jiang, Jing Guo, Ying Chen, DongSheng Yang, Xi Wang, HaoFeng Lin, Ang Li, Bei Li, Ben Hu, ZeJun Wang, XingLou Yang, ZhengLi Shi, Tom Gallagher, 2022
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concern, Yang, Jingyi, Liu, MeiQin, Liu, Lin, Li, Xian, Xu, Mengxin, Lin, Haofeng, Liu, Shuning, Hu, Yunqi, Li, Bei, Liu, Bowen, Li, Min, Sun, Ying, Chen, YaoQing, Shi, ZhengLi, Yan, Huimin, 2022
A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunity, Li, Yang, Wang, Xi, Shen, XuRui, Geng, Rong, Xie, Nan, Han, JunFeng, Zhang, QingMiao, Shi, ZhengLi, Zhou, Peng, 2022
Lethal Swine Acute Diarrhea Syndrome Coronavirus Infection in Suckling Mice, Chen, Ying, Jiang, RenDi, Wang, Qi, Luo, Yun, Liu, MeiQin, Zhu, Yan, Liu, Xi, He, YanTong, Zhou, Peng, Yang, XingLou, Shi, ZhengLi, 2022
Broad Cell Tropism of SADS-CoV In Vitro Implies Its Potential Cross-Species Infection Risk, Luo, Yun, Chen, Ying, Geng, Rong, Li, Bei, Chen, Jing, Zhao, Kai, Zheng, XiaoShuang, Zhang, Wei, Zhou, Peng, Yang, XingLou, Shi, ZhengLi, 2021
Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates, Yao, YanFeng, Wang, ZeJun, Jiang, RenDi, Hu, Xue, Zhang, HuaJun, Zhou, YiWu, Gao, Ge, Chen, Ying, Peng, Yun, Liu, MeiQin, Zhang, YaNan, Min, Juan, Lu, Jia, Gao, XiaoXiao, Guo, Jing, Peng, Cheng, Shen, XuRui, Li, Qian, Zhao, Kai, Yang, Lian, Wan, Xin, Zhang, Bo, Wang, WenHui, Wu, Jia, Zhou, Peng, Yang, XingLou, Shen, Shuo, Shan, Chao, Yuan, ZhiMing, Shi, ZhengLi, 2021
Characterization of Novel Rhabdoviruses in Chinese Bats, Luo, DongSheng, Li, Bei, Shen, XuRui, Jiang, RenDi, Zhu, Yan, Wu, Jia, Fan, Yi, Bourhy, Herve, Hu, Ben, Ge, XingYi, Shi, ZhengLi, Dache

Pathogeny Emerging Viruses Animal Viruses Molecular Epidemiology Cross-Species Transmission Mechanism Antiviral Bats Virology

Xinglou Yang - University of Chinese Academy of Sciences

Hai-Rong Xiong - Wuhan University

Lei Sun - University of Chinese Academy of Sciences

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