Areas of Focus
- Chemical Biology
- Organic Chemistry and Nucleic Acid Chemistry
Work Experience
- 2009-06~Present - Chinese Academy of Sciences, Chengdu Institute of Biology - Researcher
- 2008-03~2009-06 - McMaster University, Canada - Postdoctoral Researcher
- 2006-01~2008-03 - University of Konstanz, Germany - Postdoctoral Humboldt Scholar
Academic Background & Achievements
- 2003-07--2006-01 PhD: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
- 2000-09--2003-07 Master's: Joint program of Sichuan University and Chengdu Institute of Biology
Publications
- Synthesis of Sulfilimines via Selective S–C Bond Formation in Water, 7th Author, 2023
- Leveraging small molecule-induced aptazyme cleavage for directed A-to-I RNA editing, Corresponding Author, 2023
- Quinoxaline-specific enantioselective sulfa-michael reaction catalyzed by chiral phosphoric acid, Corresponding Author, 2023
- Biomimetic Dynamic Kinetic Asymmetric N-Oxidation with H2O2 and O2, Corresponding Author, 2023
- Live-Cell Imaging of Endogenous RNA with a Genetically Encoded Fluorogenic Allosteric Aptamer, Corresponding Author, 2023
- Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells, Corresponding Author, 2023
- One-Pot Tandem Oxidative Bromination and Amination of Sulfenamide for the Synthesis of Sulfinamidines, 6th Author, 2023
- Synthesis of Chiral Sulfonimidoyl Chloride via Desymmetrizing Enantioselective Hydrolysis, Corresponding Author, 2023
- Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α-Tertiary Amino Ketones, Corresponding Author, 2022
- Organelle-targeted imaging based on fluorogen-activating RNA aptamers in living cells, Corresponding Author, 2022
- A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function, Corresponding Author, 2022
- Detection of Cancer Marker Flap Endonuclease 1 Using One-Pot Transcription-Powered Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a Signal Expansion, Corresponding Author, 2022
- Photoredox Alkylation of Sulfinylamine Enables the Synthesis of Highly Functionalized Sulfinamides and S(VI) Derivatives, 6th Author, 2022
- Preparation of Dihydronaphthofurans from α-Hydroxyl Ketones via a One-Pot Multicomponent Reaction Based on Heyns Rearrangement, Corresponding Author, 2022
- Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp(3))-H Bromination, Corresponding Author, 2022
- Synthesis of axially chiral N-aryl benzimidazoles via chiral phosphoric acid catalyzed enantioselective oxidative aromatization, Corresponding Author, 2022
- Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity, Corresponding Author, 2022
- All-in-one multiplex isothermal reaction combining miniaturized device enables rapid screening of infected samples, Corresponding Author, 2022
- Real-time fluorescence and colorimetric identification of bulbus fritillariae using recombinase assisted loop-mediated isothermal DNA amplification (RALA), Corresponding Author, 2022
- Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement, Corresponding Author, 2021
- Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine, Corresponding Author, 2021
- Combining Protein and RNA Quantification to Evaluate Promoter Activity by Using Dual-color Fluorescent Reporting Systems, Corresponding Author, 2021
- Obtaining hammerhead aptazymes with trans-cleaving potential in vivo by rational design, 9th Author, 2021
- Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot, Corresponding Author, 2021
- Biomimetic alloxan-catalyzed intramolecular redox reaction with O2: One-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles, Corresponding Author, 2021
- Sequence-specific and multiplex detection of COVID-19 virus (SARS-CoV-2) using proofreading enzyme-mediated probe cleavage coupled with isothermal amplification, Corresponding Author, 2021
- Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs, Corresponding Author, 2021
- An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid, Corresponding Author, 2020
- Intracellular Selection of Theophylline-Sensitive Hammerhead Aptazyme, Corresponding Author, 2020
- Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen, Corresponding Author, 2020
- Ion-induced PCR strategy for mercury detection, Corresponding Author, 2020
- Recombinase assisted loop-mediated isothermal DNA amplification, Corresponding Author, 2020
- A feasibility study into ribonucleic acid aptamer being antibiotic resistance gene, Corresponding Author, 2020
- Frame-shifted proteins of a given gene retain the same function, Corresponding Author, 2020
- Pictet-Spengler reaction based onin situgenerated alpha-amino iminium ions through the Heyns rearrangement, Corresponding Author, 2020
- Chiral Bronsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity, Corresponding Author, 2019
- Preparation of Bicyclic Ketal Skeletons with Aldehyde and alpha-Ketone Acid through Cascade Friedel-Crafts Reaction and Stereoselective Acetalization in One Pot, Corresponding Author, 2019
- Colorimetric detection of genetically modified organisms(GMOs)based on loop-mediated isothermal amplification(LAMP), Corresponding Author, 2019
- Intracellular selection of trans -cleaving hammerhead ribozymes, Corresponding Author, 2019
- Polymerase Chain Reaction using \"V\" Shape Thermal Cycling Program, Corresponding Author, 2019
- One-step isothermal visual detection of pathogens based on LAMP, Corresponding Author, 2019
- From Electrophoresis Detection to Visual Judgment: New Application of SYBR Green I in the Authentication of the Traditional Medicine Rhizoma Paridis, 6th Author, 2019
- Colorimetric Detection of Horse Meat Based on Loop-Mediated Isothermal Amplification (LAMP), Corresponding Author, 0201
Awards
- Sichuan Provincial Science and Technology Progress Award, Third Prize, Provincial Level, 2021
- Advanced Worker of the Chinese Academy of Sciences, Institute Level, 2015
- 18th Sichuan Youth May Fourth Medal, Provincial Level, 2015
- Sichuan Province May 1st Labor Medal, Provincial Level, 2015
- Ten Thousand Talents Program, Ministerial Level, 2013
- National Natural Science Award, Second Prize, National Level, 2013
- Introduction of Outstanding Foreign Talents, Institute Level, 2010
- National Excellent Doctoral Dissertation Award, National Level, 2008
- Humboldt Scholarship, National Level, 2006
- Special Award of the President of the Chinese Academy of Sciences, Institute Level, 2005
