Areas of Focus
- Drug Chemistry
- Organic Synthesis
Work Experience
- 2023-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
- 2013-07~2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
- 2011-04~2013-06 - Peking University - Postdoctoral Researcher
Academic Background & Achievements
- 2005-09--2010-06 PhD: Nankai University
- 2001-09--2005-06 Bachelor's: Nankai University
Publications
- Copper/ Chiral Phosphoric Acid-Catalyzed Intramolecular Reductive Isocyanide-Alkene (1+2) Cycloaddition: Enantioselective Construction of 2-Azabicyclo[3.1.0]hexanes., J. Am. Chem. Soc, 2024
- Immobilizing Stereogenic Nitrogen Center in Doubly Fused Triarylamines through Palladium-Catalyzed Asymmetric C-H Activation/Seven-Membered-Ring Formation, ACS CATALYSIS, 2023
- CPA-catalyzed asymmetric domino thia-Michael/aldol reactions for simultaneous chiral center and axial chirality formation, ORGANIC & BIOMOLECULAR CHEMISTRY, 2023
- fl-Boron Effect Enables Regioselective and Stereospecific Electrophilic Addition to Alkenes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023
- Palladium-catalyzed alkyne hydrocarbonylation under atmospheric pressure of carbon monoxide in the presence of hydrosilane, GREEN CHEMISTRY, 2023
- Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center., ACS Catal., 2022
- Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization., ACS Catal., 2022
- Palladium-Catalyzed Four-Component Cascade Imidoyl-Carbamoylation of Unactivated Alkenes, ACS Catalysis, 2022
- Palladium-catalyzed tandem Heck/carbonylation/aminocarbonylation en route to chiral heterocyclic alpha-ketoamides, ORGANIC CHEMISTRY FRONTIERS, 2022
- Palladium-Catalyzed Tandem Heck/Carbonylation/Aminocarbonylation En Route to Chiral Heterocyclic α-Ketoamides., ORGANICCHEMISTRYFRONTIERS, 2022
- A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism, iScience, 2022
- Inherently Chiral 6,7-Diphenyldibenzo[e,g][1,4]diazocine: Enantioselective Synthesis and Application as a Ligand Platform., CCS Chemistry, 2022
- A New Saddle-Shaped Aza Analog of Tetraphenylene: Atroposelective Synthesis and Application as a Chiral Acylating Reagent., CCS Chemistry, 2021
- Palladium-Catalyzed Atroposelective Coupling-Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021
- Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzob,dazepin-6-ones, ORGANIC LETTERS, 2021
- Pd-catalyzed imine-directed intramolecular CsbndN bond formation through C(sp3)sbndH activation: An efficient approach to multisubstituted pyrroles, TETRAHEDRON LETTERS, 2020
- Pd-catalyzed imine-directed intramolecular C-N bond formation through C(sp(3))-H activation: An efficient approach to multisubstituted pyrroles, TETRAHEDRON LETTERS, 2020
- Pd-Catalyzed Domino Imidoylation/Heck/C(sp(2))-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center, ORGANIC LETTERS, 2020
- Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019
- Selective C-H or N-H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds, ADVANCED SYNTHESIS & CATALYSIS, 2019
- Pd-Catalyzed C(sp(2))-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines, JOURNAL OF ORGANIC CHEMISTRY, 2019
- Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions, ORGANIC LETTERS, 2018
- Stirring-controlled mono or double aminocarbonylation of 1,3-bis(2-iodoaryl)propan-2-amines, TETRAHEDRON LETTERS, 2018
- Palladium-catalyzed beta-selective C(sp(2))-H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides, ORGANIC CHEMISTRY FRONTIERS, 2017
- Palladium-catalyzed C(sp(2))-H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles, ORGANIC CHEMISTRY FRONTIERS, 2017
- Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides, Org. Chem. Front., 2017
- Pd-Catalyzed C(sp(2))-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones, CHEMICAL COMMUNICATIONS, 2016
- Dearomative C-C and C-N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones, ORGANIC CHEMISTRY FRONTIERS, 2016
- A metal-free synthesis of 2-aminobenzothiazoles through aminyl radical addition to aryl isothiocyanates, CHEMICAL COMMUNICATIONS, 2016
- Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates, ADVANCED SYNTHESIS & CATALYSIS, 2015
- Palladium-catalyzed intermolecular C-H amidation of indoles with sulfonyl azides, SCIENCE CHINA-CHEMISTRY, 2015
- Palladium-Catalyzed Intramolecular C(sp(2))-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles, JOURNAL OF ORGANIC CHEMISTRY, 2015
- A room-temperature synthesis of 2,2 '-bisoxazoles through palladium-catalyzed oxidative coupling of alpha-isocyanoacetamides, ORGANIC CHEMISTRY FRONTIERS, 2014
- Copper-mediated C(sp(2))-H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines, ORGANIC CHEMISTRY FRONTIERS, 2014
- Palladium-Catalyzed Imidoylative Cyclization of alpha-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles, CHEMISTRY-A EUROPEAN JOURNAL, 2014
- Palladium-Catalyzed Imidoylative Cyclization of a- Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles, Chem. Eur. J., 2014
- Synthesis of Dibenzopyranones through Palladium-Catalyzed Directed C-H Activation/Carbonylation of 2-Arylphenols, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013
- Palladium-Catalyzed Trifluoromethylation of Aromatic C-H Bond Directed by an Acetamino Group, ORGANIC LETTERS, 2013
- Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp(3) C-O bond cleavage, CHEMICAL COMMUNICATIONS, 2013
