Professor | Hong Tang | Asia Growth Partners

Name	Hong Tang
Contact Information	htang@ips.ac.cn
Language ability	English, Chinese
Province	Shanghai

Name

Hong Tang

Contact Information

htang@ips.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1991-01--1996-05 PhD: Rutgers University-New Jersey State University 1988-09--1990-12 Master's: Institute of Microbiology, Chinese Academy of Sciences 1984-09--1988-07 Bachelor's: Nanjing University
Work Experience	2016-present - Shanghai Pasteur Institute, Chinese Academy of Sciences - Researcher, Director 2012-2016 - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher, Deputy Director 2009-2012 - Key Laboratory of Infection and Immunity, Chinese Academy of Sciences - Director 2007-present - National International Joint Research Center, Ministry of Science and Technology - Director 2006-2009 - National Key Laboratory of Biomacromolecules - Deputy Director 2005-2012 - Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences - Researcher, Director 2001-2005 - Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences - Researcher, Director 2000 - Dupont Pharmaceutical Co - Senior Scientist 1996-1999 - Massachusetts Institute of Technology - Postdoctoral Researcher
Awards	Beijing Science and Technology Award, First Prize, Provincial, 2012 Fourth China Overseas Chinese Contribution Award (Innovation Team), First Prize, National, 2012 New Century Talents Project, National, 2009 Second Tan Jiazhen Life Science Innovation Award, Other, 2009 Jiangsu High-level Entrepreneurial and Innovative Talent Introduction Plan, Provincial, 2009

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1991-01--1996-05 PhD: Rutgers University-New Jersey State University
1988-09--1990-12 Master's: Institute of Microbiology, Chinese Academy of Sciences
1984-09--1988-07 Bachelor's: Nanjing University

Work Experience

2016-present - Shanghai Pasteur Institute, Chinese Academy of Sciences - Researcher, Director
2012-2016 - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher, Deputy Director
2009-2012 - Key Laboratory of Infection and Immunity, Chinese Academy of Sciences - Director
2007-present - National International Joint Research Center, Ministry of Science and Technology - Director
2006-2009 - National Key Laboratory of Biomacromolecules - Deputy Director
2005-2012 - Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences - Researcher, Director
2001-2005 - Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences - Researcher, Director
2000 - Dupont Pharmaceutical Co - Senior Scientist
1996-1999 - Massachusetts Institute of Technology - Postdoctoral Researcher

Awards

Beijing Science and Technology Award, First Prize, Provincial, 2012
Fourth China Overseas Chinese Contribution Award (Innovation Team), First Prize, National, 2012
New Century Talents Project, National, 2009
Second Tan Jiazhen Life Science Innovation Award, Other, 2009
Jiangsu High-level Entrepreneurial and Innovative Talent Introduction Plan, Provincial, 2009

Areas of Focus	Molecular and Signal Transduction Mechanisms of Innate Immune Recognition and Response Mechanisms of Innate Immune Response to Viral Infections Inflammatory Response and Its Regulatory Mechanisms Development of Immune Cells and Organs
Publications	Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila, Hong Tang, 2019 NKG2A is a NK cell exhaustion checkpoint for HCV persistence, Hong Tang, 2019 B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen, Hong Tang, 2018 Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice, Hong Tang, 2017 Macrophage-derived IL-1a promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity, Hong Tang, 2017 Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection, Hong Tang, 2017 Aberrant coagulation causesa hyper-inflammatory response in severe influenza pneumonia, Hong Tang, 2016 Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice, Hong Tang, 2014 Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection, Hong Tang, 2013 Sequential reassortments underlie diverse influenza H7N9 genotypes in China, Hong Tang, 2013 Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins, Hong Tang, 2013 PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway, Hong Tang, 2011 TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I, Hong Tang, 2011 MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes, Hong Tang, 2010 Do adaptive immune cells suppress or activate innate immunity, Hong Tang, 2009 Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma, Hong Tang, 2009 Hyper innate responses in neonates lead to increased morbidity and mortality after infection., Hong Tang, 2008 PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production, Hong Tang, 2008 Adaptive immune cells temper initial innate responses, Hong Tang, 2007

Areas of Focus

Molecular and Signal Transduction Mechanisms of Innate Immune Recognition and Response
Mechanisms of Innate Immune Response to Viral Infections
Inflammatory Response and Its Regulatory Mechanisms
Development of Immune Cells and Organs

Publications

Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila, Hong Tang, 2019
NKG2A is a NK cell exhaustion checkpoint for HCV persistence, Hong Tang, 2019
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen, Hong Tang, 2018
Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice, Hong Tang, 2017
Macrophage-derived IL-1a promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity, Hong Tang, 2017
Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection, Hong Tang, 2017
Aberrant coagulation causesa hyper-inflammatory response in severe influenza pneumonia, Hong Tang, 2016
Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice, Hong Tang, 2014
Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection, Hong Tang, 2013
Sequential reassortments underlie diverse influenza H7N9 genotypes in China, Hong Tang, 2013
Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins, Hong Tang, 2013
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway, Hong Tang, 2011
TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I, Hong Tang, 2011
MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes, Hong Tang, 2010
Do adaptive immune cells suppress or activate innate immunity, Hong Tang, 2009
Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma, Hong Tang, 2009
Hyper innate responses in neonates lead to increased morbidity and mortality after infection., Hong Tang, 2008
PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production, Hong Tang, 2008
Adaptive immune cells temper initial innate responses, Hong Tang, 2007

Innate Immunity Signal Transduction Viral Infections Immune Response Inflammation Regulation Immune Cells Immune Organs Molecular Mechanisms Development

Min Liu - Wuhan University

Li Chen - Wuhan University

Qiang Tu - University of Chinese Academy of Sciences

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