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Li Chen
Medical School
Wuhan University
Hubei
Language: English, Chinese
Rna
Epigenetics
Chemical Biology
Research Techniques
Modifications
Longevity
Vitamins
Anti-Aging
Molecular Mechanisms
Development
Areas of Focus
- RNA Chemical Biology: Developing research techniques for studying epigenetic modifications of RNA
- Molecular mechanisms of anti-aging by 'longevity vitamins'
Work Experience
- 2023.10-present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University
- 2021.10-2023.09 Research Assistant, School of Pharmaceutical Sciences, Wuhan University
- 2019.09-2021.09 Joint Postdoctoral Researcher, Department of Chemistry, University of Chicago, Supervisors: Chuan He, Bryan C. Dickinson
- 2018.07-2019.08 Joint Postdoctoral Researcher, Department of Pharmacy, Ohio State University, Supervisor: Kou-San Ju
- 2018.07-2021.09 Postdoctoral Researcher, School of Basic Medical Sciences, Wuhan University, Supervisor: Xuechuan Hong
Academic Background & Achievements
- 2013-2018 PhD: School of Pharmaceutical Sciences, Wuhan University, Supervisor: Zixin Deng
- 2016-2018 Joint PhD: Department of Chemistry, Boston University, Supervisor: Pinghua Liu
Publications
- Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation, Chen L, Zhang L-S, Ye C, Zhou H, Deng Z, Zhao C, He C, Dickinson B, 2023
- Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
- Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis that is Broadly Conserved in Nature, Zhang Y, Chen L, Wilson J, Cui J, Roodhouse H, Kayrouz C, Pham T, Ju K-S, 2022
- Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
- Use of a Tyrosine Analogue to Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
- Mini-Review: Ergothioneine and Ovothiol Biosynthesis, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
- Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
- High-throughput screening for Streptomyces antibiotic biosynthesis activators, Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M, 2012
Awards
- Wuhan University Science and Technology Innovation First Prize (2018)
- Graduate National Scholarship (2016)
