Professor | Li Chen | Asia Growth Partners

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Name	Li Chen
Contact Information	chenli1012@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Li Chen

Contact Information

chenli1012@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2013-2018 PhD: School of Pharmaceutical Sciences, Wuhan University, Supervisor: Zixin Deng 2016-2018 Joint PhD: Department of Chemistry, Boston University, Supervisor: Pinghua Liu
Work Experience	2023.10-present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University 2021.10-2023.09 Research Assistant, School of Pharmaceutical Sciences, Wuhan University 2019.09-2021.09 Joint Postdoctoral Researcher, Department of Chemistry, University of Chicago, Supervisors: Chuan He, Bryan C. Dickinson 2018.07-2019.08 Joint Postdoctoral Researcher, Department of Pharmacy, Ohio State University, Supervisor: Kou-San Ju 2018.07-2021.09 Postdoctoral Researcher, School of Basic Medical Sciences, Wuhan University, Supervisor: Xuechuan Hong
Awards	Wuhan University Science and Technology Innovation First Prize (2018) Graduate National Scholarship (2016)

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2013-2018 PhD: School of Pharmaceutical Sciences, Wuhan University, Supervisor: Zixin Deng
2016-2018 Joint PhD: Department of Chemistry, Boston University, Supervisor: Pinghua Liu

Work Experience

2023.10-present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University
2021.10-2023.09 Research Assistant, School of Pharmaceutical Sciences, Wuhan University
2019.09-2021.09 Joint Postdoctoral Researcher, Department of Chemistry, University of Chicago, Supervisors: Chuan He, Bryan C. Dickinson
2018.07-2019.08 Joint Postdoctoral Researcher, Department of Pharmacy, Ohio State University, Supervisor: Kou-San Ju
2018.07-2021.09 Postdoctoral Researcher, School of Basic Medical Sciences, Wuhan University, Supervisor: Xuechuan Hong

Awards

Wuhan University Science and Technology Innovation First Prize (2018)
Graduate National Scholarship (2016)

Areas of Focus	RNA Chemical Biology: Developing research techniques for studying epigenetic modifications of RNA Molecular mechanisms of anti-aging by 'longevity vitamins'
Publications	Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation, Chen L, Zhang L-S, Ye C, Zhou H, Deng Z, Zhao C, He C, Dickinson B, 2023 Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023 Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis that is Broadly Conserved in Nature, Zhang Y, Chen L, Wilson J, Cui J, Roodhouse H, Kayrouz C, Pham T, Ju K-S, 2022 Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019 Use of a Tyrosine Analogue to Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018 Mini-Review: Ergothioneine and Ovothiol Biosynthesis, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018 Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015 High-throughput screening for Streptomyces antibiotic biosynthesis activators, Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M, 2012

Areas of Focus

RNA Chemical Biology: Developing research techniques for studying epigenetic modifications of RNA
Molecular mechanisms of anti-aging by 'longevity vitamins'

Publications

Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation, Chen L, Zhang L-S, Ye C, Zhou H, Deng Z, Zhao C, He C, Dickinson B, 2023
Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis that is Broadly Conserved in Nature, Zhang Y, Chen L, Wilson J, Cui J, Roodhouse H, Kayrouz C, Pham T, Ju K-S, 2022
Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
Use of a Tyrosine Analogue to Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
Mini-Review: Ergothioneine and Ovothiol Biosynthesis, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
High-throughput screening for Streptomyces antibiotic biosynthesis activators, Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M, 2012

Rna Epigenetics Chemical Biology Research Techniques Modifications Longevity Vitamins Anti-Aging Molecular Mechanisms Development

Kun Shen - Wuhan University

Duozhi Chen - University of Chinese Academy of Sciences

Jing Liu - University of Chinese Academy of Sciences

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