Areas of Focus
- Proteomics
- Post-translational Modifications
- Biomass Spectrometry
- Precision Medicine
Work Experience
- 2012-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader, Doctoral Supervisor
- 2008-10~2012-08 - University of Chicago - Postdoctoral Researcher
- 2008-08~2008-09 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
Academic Background & Achievements
- 2003-09--2008-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1999-09--2003-07 Bachelor: Fudan University
Publications
- DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition., Lu Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R, Wu Q, Wu L*, Meng Z*, Tan M*, Li J*., 2024
- Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells., Hu H, Hu W, Guo AD, Zhai L, Ma S, Nie HJ, Zhou BS, Liu T, Jia X, Liu X, Yao X, Tan M*, Chen X*., 2024
- Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors., Guo A, Yan K, Hu, H, Zhai L, Hu T, Su,H, Chi Y, Zha,J, Xu Y, Zhao,Y Lu X, Xu Y, Zhang J, Tan M*, Chen X*., 2023
- ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA- Encoded Libraries., Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M,* Lu X,* Zhou L.*, 2023
- Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha., Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH*, Tan M*, Zhao B*., 2022
- A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies., Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*., 2021
- DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing., Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*., 2021
- Integrative proteomic characterization of human lung adenocarcinoma., Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun C, Liu Z, Jiang S, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang X, Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*., 2020
- Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors., Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*., 2018
- Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis., Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*., 2018
- Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5., Tan, M.#, Peng, C.#, Anderson, K.A.#, Chhoy, P., Xie, Z., Dai, L., Park, J.S., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G.R., Green, M.F., Madsen, A.S., Schmiesing, J., Peterson, B.S., Xu, G., Ilkayeva, O.R., Muehlbauer, M.J., Braulke, T., Mühlhausen, C., Backos, D.S., Olsen, C.A., McGuire, P.J., Pletcher, S.D., Lombard, D.B., Hirschey, M.D.*, Zhao, Y*., 2014
- Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification., Tan M.#, Luo H.#, Lee S.#, Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y*., 2011
- Identification of lysine succinylation as a new post-translational modification., Zhang, Z.#, Tan, M.#, Xie, Z., Dai, L., Chen, Y., Zhao, Y*., 2011
Awards
- 2023: First Prize in Natural Science Award, Ministry of Education
- 2022: National Science Fund for Distinguished Young Scholars
- 2022: 17th China Youth Science and Technology Award
- 2022: 11th Shanghai Youth Science and Technology Talent (Basic Research Category)
- 2022: Shanghai Excellent Academic/Technical Leader
- 2020: 7th Outstanding Youth Science and Technology Innovation Talent, Shanghai Branch of Chinese Academy of Sciences
- 2020: WuXi AppTec Life Chemistry Research Award
- 2019: 4th Zhongyuan Concord Life Medicine Innovation Breakthrough Award
- 2018: Leading Talent in Science and Technology Innovation, Ministry of Science and Technology
- 2013: Excellent Young Scholar Award, 8th China Human Proteome Conference
