Professor | Donghai Wu | Asia Growth Partners

Name	Donghai Wu
Contact Information	wu_donghai@gibh.ac.cn
Language ability	English, Chinese
Province	Guangdong

Name

Donghai Wu

Contact Information

wu_donghai@gibh.ac.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1980-1984 Bachelor's Degree: Beijing Normal University 1985-1990 Ph.D.: University of Texas Southwestern Medical Center
Work Experience	1990-1992 - University of Texas Southwestern Medical Center - Postdoctoral Fellow 1992-1994 - University of Kentucky - Assistant Research Professor 1994-1998 - University of Kentucky - Assistant Professor 1998-2004 - University of Florida - Assistant Professor 2004-Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1980-1984 Bachelor's Degree: Beijing Normal University
1985-1990 Ph.D.: University of Texas Southwestern Medical Center

Work Experience

1990-1992 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
1992-1994 - University of Kentucky - Assistant Research Professor
1994-1998 - University of Kentucky - Assistant Professor
1998-2004 - University of Florida - Assistant Professor
2004-Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher

Areas of Focus	Fatty Acid Metabolism Regulation Adipocyte Differentiation and Transdifferentiation Diagnosis and Treatment of Metabolic Diseases
Publications	Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist, Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu, 2021 The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis, Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai, 2021 Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour, Huang, HuaLin, Li, Caiyue, Ma, Wenbo, Yin, Shikui, Zhao, Huifan, Deng, Sihao, Shu, Xiaodong, Wu, Donghai, Li, Ji, Huang, Rongqi, Cheng, Na, Huang, Jufang, Li, Zhiyuan, 2020 Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure, Zhang, Shaoping, Liu, Hong, Amarsingh, Greeshma Vazhoor, Cheung, Carlos C H, Wu, Donghai, Narayanan, Umayal, Zhang, Linda, Cooper, Garth J S, 2020 High-efficiency protein delivery into transfection-recalcitrant cell types, Li, Zhenpeng, Cai, Zeqiong, Fu, Weixin, Liu, Ying, Tian, Chenglei, Wang, He, Fu, Tongtong, Wu, Zhenzhou, Wu, Donghai, Jin, Yongxin, Cheng, Zhihui, Terada, Naohiro, Liu, Lin, Wu, Weihui, Jin, Shouguang, Bai, Fang, 2020 Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities, Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong, 2020 Establishment of porcine and human expanded potential stem cells, Gao, Xuefei, NowakImialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, EckersleyMaslin, Melanie A, Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S, Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, SongGuo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J, Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P L, Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A, Niemann, Heiner, Liu, Pentao, 2019 Production of a novel Poria cocos immunomodulatory protein in Pichia pastoris: cloning, expression, purification and activities assays, Li, Hongbo, Bu, Xiufen, Li, Kuai, Wu, Donghai, 2019 Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, Yi, Shiting, Chu, Yi, Zhang, Yuwei, Zhou, Yulai, Jiang, Zhiwu, Wang, Zhengqi, Mao, Liufeng, Li, Kuai, Sun, Wei, Li, Peng, Jia, Shiqi, Wang, Cunchuan, Xu, Aimin, Loomes, Kerry, Tang, Shibing, Wu, Donghai, Hui, Xiaoyan, Nie, Tao, 2019 Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer, Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong, 2019 Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer, Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong, 2018 Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesity, Mao, Liufeng, Lei, Jiwen, Schoemaker, Marieke H, Ma, Bingxiu, Zhong, Yan, Lambers, Tim T, Van Tol, Eric A F, Zhou, Yulai, Nie, Tao, Wu, Donghai, 2018 重组嗜热乳糖酶在毕赤酵母中的表达、纯化与活性分析, 李洪波, 罗海燕, 张树琴, 吴东海, 2018 Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery, Jin, Yongxin, Liu, Ying, Li, Zhenpeng, Santostefano, Katherine, Shi, Jing, Zhang, Xinwen, Wu, Donghai, Cheng, Zhihui, Wu, Weihui, Terada, Naohiro, Jin, Shouguang, Bai, Fang, 2018 Uncoupling protein-1 is protective of bone mass under mild cold stress conditions, Nguyen, Amy D, Lee, Nicola J, Wee, Natalie K Y, Zhang, Lei, Enriquez, Ronaldo F, Khor, Ee Cheng, Nie, Tao, Wu, Donghai, Sainsbury, Amanda, Baldock, Paul A, Herzog, Herbert, 2018 Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system, Wang, Baile, Li, Ang, Li, Xiaomu, Ho, Philip Wl, Wu, Donghai, Wang, Xiaoqi, Liu, Zhuohao, Wu, Kelvin K L, Yau, Sonata S Y, Xu, Aimin, Cheng, Kenneth K Y, 2018 Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Sun, Wai Yan, Bai, Bo, Luo, Cuiting, Yang, Kangmin, Li, Dahui, Wu, Donghai, Feletou, Michel, Villeneuve, Nicole, Zhou, Yang, Yang, Junwei, Xu, Aimin, Vanhoutte, Paul M, Wang, Yu, 2018 The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity, Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai, 2018 Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC), Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong, 2018 Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, Hui, Xiaoyan, Zhang, Mingliang, Gu, Ping, Li, Kuai, Gao, Yuan, Wu, Donghai, Wang, Yu, Xu, Aimin, 2017 Brown Adipogenic Reprogramming Induced by a Small Molecule, Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gu, Ping, Mao, Liufeng, Li, Kuai, Yuan, Ran, Zheng, Jiashun, Wang, Haixia, Li, Ke, Tang, Shibing, Zhang, Yu, Xu, Tao, Xu, Aimin, Wu, Donghai, Ding, Sheng, 2017 CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency, Xinru Wei, Yunxin Lai, Baiheng Li, Le Qin, Youdi Xu, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Guohua Huang, Qiuhua Deng, Pentao Liu, Donghai Wu, Liangxue Lai, Yao Yao, Peng Li, 2017 Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy, Hoo, Ruby L C, Shu, Lingling, Cheng, Kenneth K Y, Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhigu

Areas of Focus

Fatty Acid Metabolism Regulation
Adipocyte Differentiation and Transdifferentiation
Diagnosis and Treatment of Metabolic Diseases

Publications

Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist, Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu, 2021
The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis, Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai, 2021
Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour, Huang, HuaLin, Li, Caiyue, Ma, Wenbo, Yin, Shikui, Zhao, Huifan, Deng, Sihao, Shu, Xiaodong, Wu, Donghai, Li, Ji, Huang, Rongqi, Cheng, Na, Huang, Jufang, Li, Zhiyuan, 2020
Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure, Zhang, Shaoping, Liu, Hong, Amarsingh, Greeshma Vazhoor, Cheung, Carlos C H, Wu, Donghai, Narayanan, Umayal, Zhang, Linda, Cooper, Garth J S, 2020
High-efficiency protein delivery into transfection-recalcitrant cell types, Li, Zhenpeng, Cai, Zeqiong, Fu, Weixin, Liu, Ying, Tian, Chenglei, Wang, He, Fu, Tongtong, Wu, Zhenzhou, Wu, Donghai, Jin, Yongxin, Cheng, Zhihui, Terada, Naohiro, Liu, Lin, Wu, Weihui, Jin, Shouguang, Bai, Fang, 2020
Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities, Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong, 2020
Establishment of porcine and human expanded potential stem cells, Gao, Xuefei, NowakImialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, EckersleyMaslin, Melanie A, Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S, Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, SongGuo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J, Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P L, Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A, Niemann, Heiner, Liu, Pentao, 2019
Production of a novel Poria cocos immunomodulatory protein in Pichia pastoris: cloning, expression, purification and activities assays, Li, Hongbo, Bu, Xiufen, Li, Kuai, Wu, Donghai, 2019
Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, Yi, Shiting, Chu, Yi, Zhang, Yuwei, Zhou, Yulai, Jiang, Zhiwu, Wang, Zhengqi, Mao, Liufeng, Li, Kuai, Sun, Wei, Li, Peng, Jia, Shiqi, Wang, Cunchuan, Xu, Aimin, Loomes, Kerry, Tang, Shibing, Wu, Donghai, Hui, Xiaoyan, Nie, Tao, 2019
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer, Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong, 2019
Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer, Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong, 2018
Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesity, Mao, Liufeng, Lei, Jiwen, Schoemaker, Marieke H, Ma, Bingxiu, Zhong, Yan, Lambers, Tim T, Van Tol, Eric A F, Zhou, Yulai, Nie, Tao, Wu, Donghai, 2018
重组嗜热乳糖酶在毕赤酵母中的表达、纯化与活性分析, 李洪波, 罗海燕, 张树琴, 吴东海, 2018
Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery, Jin, Yongxin, Liu, Ying, Li, Zhenpeng, Santostefano, Katherine, Shi, Jing, Zhang, Xinwen, Wu, Donghai, Cheng, Zhihui, Wu, Weihui, Terada, Naohiro, Jin, Shouguang, Bai, Fang, 2018
Uncoupling protein-1 is protective of bone mass under mild cold stress conditions, Nguyen, Amy D, Lee, Nicola J, Wee, Natalie K Y, Zhang, Lei, Enriquez, Ronaldo F, Khor, Ee Cheng, Nie, Tao, Wu, Donghai, Sainsbury, Amanda, Baldock, Paul A, Herzog, Herbert, 2018
Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system, Wang, Baile, Li, Ang, Li, Xiaomu, Ho, Philip Wl, Wu, Donghai, Wang, Xiaoqi, Liu, Zhuohao, Wu, Kelvin K L, Yau, Sonata S Y, Xu, Aimin, Cheng, Kenneth K Y, 2018
Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Sun, Wai Yan, Bai, Bo, Luo, Cuiting, Yang, Kangmin, Li, Dahui, Wu, Donghai, Feletou, Michel, Villeneuve, Nicole, Zhou, Yang, Yang, Junwei, Xu, Aimin, Vanhoutte, Paul M, Wang, Yu, 2018
The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity, Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai, 2018
Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC), Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong, 2018
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, Hui, Xiaoyan, Zhang, Mingliang, Gu, Ping, Li, Kuai, Gao, Yuan, Wu, Donghai, Wang, Yu, Xu, Aimin, 2017
Brown Adipogenic Reprogramming Induced by a Small Molecule, Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gu, Ping, Mao, Liufeng, Li, Kuai, Yuan, Ran, Zheng, Jiashun, Wang, Haixia, Li, Ke, Tang, Shibing, Zhang, Yu, Xu, Tao, Xu, Aimin, Wu, Donghai, Ding, Sheng, 2017
CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency, Xinru Wei, Yunxin Lai, Baiheng Li, Le Qin, Youdi Xu, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Guohua Huang, Qiuhua Deng, Pentao Liu, Donghai Wu, Liangxue Lai, Yao Yao, Peng Li, 2017
Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy, Hoo, Ruby L C, Shu, Lingling, Cheng, Kenneth K Y, Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhigu

Fatty Acid Metabolism Adipocyte Differentiation Transdifferentiation Metabolic Diseases Obesity Diabetes Molecular Mechanisms Early Diagnosis Treatment Biomedicine

Hao Chen - Southern University of Science and Technology

Juanjuan Guo - Wuhan University

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