Areas of Focus
- Fatty Acid Metabolism Regulation
- Adipocyte Differentiation and Transdifferentiation
- Diagnosis and Treatment of Metabolic Diseases
Work Experience
- 1990-1992 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
- 1992-1994 - University of Kentucky - Assistant Research Professor
- 1994-1998 - University of Kentucky - Assistant Professor
- 1998-2004 - University of Florida - Assistant Professor
- 2004-Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
Academic Background & Achievements
- 1980-1984 Bachelor's Degree: Beijing Normal University
- 1985-1990 Ph.D.: University of Texas Southwestern Medical Center
Publications
- Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist, Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu, 2021
- The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis, Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai, 2021
- Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour, Huang, HuaLin, Li, Caiyue, Ma, Wenbo, Yin, Shikui, Zhao, Huifan, Deng, Sihao, Shu, Xiaodong, Wu, Donghai, Li, Ji, Huang, Rongqi, Cheng, Na, Huang, Jufang, Li, Zhiyuan, 2020
- Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure, Zhang, Shaoping, Liu, Hong, Amarsingh, Greeshma Vazhoor, Cheung, Carlos C H, Wu, Donghai, Narayanan, Umayal, Zhang, Linda, Cooper, Garth J S, 2020
- High-efficiency protein delivery into transfection-recalcitrant cell types, Li, Zhenpeng, Cai, Zeqiong, Fu, Weixin, Liu, Ying, Tian, Chenglei, Wang, He, Fu, Tongtong, Wu, Zhenzhou, Wu, Donghai, Jin, Yongxin, Cheng, Zhihui, Terada, Naohiro, Liu, Lin, Wu, Weihui, Jin, Shouguang, Bai, Fang, 2020
- Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities, Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong, 2020
- Establishment of porcine and human expanded potential stem cells, Gao, Xuefei, NowakImialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, EckersleyMaslin, Melanie A, Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S, Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, SongGuo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J, Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P L, Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A, Niemann, Heiner, Liu, Pentao, 2019
- Production of a novel Poria cocos immunomodulatory protein in Pichia pastoris: cloning, expression, purification and activities assays, Li, Hongbo, Bu, Xiufen, Li, Kuai, Wu, Donghai, 2019
- Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation, Yi, Shiting, Chu, Yi, Zhang, Yuwei, Zhou, Yulai, Jiang, Zhiwu, Wang, Zhengqi, Mao, Liufeng, Li, Kuai, Sun, Wei, Li, Peng, Jia, Shiqi, Wang, Cunchuan, Xu, Aimin, Loomes, Kerry, Tang, Shibing, Wu, Donghai, Hui, Xiaoyan, Nie, Tao, 2019
- Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer, Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong, 2019
- Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer, Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong, 2018
- Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesity, Mao, Liufeng, Lei, Jiwen, Schoemaker, Marieke H, Ma, Bingxiu, Zhong, Yan, Lambers, Tim T, Van Tol, Eric A F, Zhou, Yulai, Nie, Tao, Wu, Donghai, 2018
- 重组嗜热乳糖酶在毕赤酵母中的表达、纯化与活性分析, 李洪波, 罗海燕, 张树琴, 吴东海, 2018
- Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery, Jin, Yongxin, Liu, Ying, Li, Zhenpeng, Santostefano, Katherine, Shi, Jing, Zhang, Xinwen, Wu, Donghai, Cheng, Zhihui, Wu, Weihui, Terada, Naohiro, Jin, Shouguang, Bai, Fang, 2018
- Uncoupling protein-1 is protective of bone mass under mild cold stress conditions, Nguyen, Amy D, Lee, Nicola J, Wee, Natalie K Y, Zhang, Lei, Enriquez, Ronaldo F, Khor, Ee Cheng, Nie, Tao, Wu, Donghai, Sainsbury, Amanda, Baldock, Paul A, Herzog, Herbert, 2018
- Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system, Wang, Baile, Li, Ang, Li, Xiaomu, Ho, Philip Wl, Wu, Donghai, Wang, Xiaoqi, Liu, Zhuohao, Wu, Kelvin K L, Yau, Sonata S Y, Xu, Aimin, Cheng, Kenneth K Y, 2018
- Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Sun, Wai Yan, Bai, Bo, Luo, Cuiting, Yang, Kangmin, Li, Dahui, Wu, Donghai, Feletou, Michel, Villeneuve, Nicole, Zhou, Yang, Yang, Junwei, Xu, Aimin, Vanhoutte, Paul M, Wang, Yu, 2018
- The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity, Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai, 2018
- Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC), Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong, 2018
- Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue, Hui, Xiaoyan, Zhang, Mingliang, Gu, Ping, Li, Kuai, Gao, Yuan, Wu, Donghai, Wang, Yu, Xu, Aimin, 2017
- Brown Adipogenic Reprogramming Induced by a Small Molecule, Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gu, Ping, Mao, Liufeng, Li, Kuai, Yuan, Ran, Zheng, Jiashun, Wang, Haixia, Li, Ke, Tang, Shibing, Zhang, Yu, Xu, Tao, Xu, Aimin, Wu, Donghai, Ding, Sheng, 2017
- CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(-/-) Mice Results in Severe Immunodeficiency, Xinru Wei, Yunxin Lai, Baiheng Li, Le Qin, Youdi Xu, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Guohua Huang, Qiuhua Deng, Pentao Liu, Donghai Wu, Liangxue Lai, Yao Yao, Peng Li, 2017
- Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy, Hoo, Ruby L C, Shu, Lingling, Cheng, Kenneth K Y, Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhigu
