Areas of Focus
- Virus-host interaction mechanisms
- Antiviral immune response and viral immune evasion
Work Experience
- 2018-10 to Present - Wuhan Institute of Virology, CAS - Director
- 2015-12 to 2018-10 - Wuhan Institute of Virology, CAS - Deputy Director
- 2014-12 to 2015-12 - Wuhan Institute of Virology, CAS - Assistant Director
- 2014-07 to 2015-06 - Wuchang District Health and Family Planning Commission - Deputy Director
- 2012-03 to Present - Wuhan Institute of Virology, CAS - Researcher
- 2010-11 to 2012-02 - Wuhan University School of Life Sciences - Associate Professor
- 2006-08 to 2010-10 - Wuhan University School of Life Sciences - Lecturer
Academic Background & Achievements
- 2007-09 to 2010-06 PhD: Wuhan University
- 2004-08 to 2006-06 Master's: University of Colorado School of Medicine
- 2000-09 to 2004-06 Bachelor's: Peking University
Publications
- LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus, Yan Yi Wang, 2024
- African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation, Yan Yi Wang, 2023
- Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes, Yan Yi Wang, 2022
- African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity, Yan Yi Wang, 2022
- Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity, Yan Yi Wang, 2022
- SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5, Yan Yi Wang, 2021
- FAM177A1 Inhibits IL-1β–Induced Signaling by Impairing TRAF6–Ubc13 Association, Yan Yi Wang, 2021
- SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response, Yan Yi Wang, 2021
- Capillary electrophoresis based on nucleic acid analysis for diagnosing inherited diseases, Yan Yi Wang, 2021
- Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes, Yan Yi Wang, 2020
- Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques, Yan Yi Wang, 2020
- SRP54NegativelyRegulatesIFN-BetaProductionandAntiviralResponsebyTargetingRIG-IandMDA5, Yan Yi Wang, 2020
- Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response., Yan Yi Wang, 2020
- Histone deacetylase 4 inhibits NF-kappa B activation by facilitating I kappa B alpha sumoylation, Yan Yi Wang, 2020
- RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization, Yan Yi Wang, 2020
- SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response, Yan Yi Wang, 2020
- Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response, Yan Yi Wang, 2020
- USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA, Yan Yi Wang, 2020
- Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients, Yan Yi Wang, 2020
- Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response, Yan Yi Wang, 2020
- SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication, Yan Yi Wang, 2020
- YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking, Yan Yi Wang, 2019
- Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3, Yan Yi Wang, 2019
- FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis, Yan Yi Wang, 2019
- RNF152 positively regulatesTLR/IL signaling by enhancing signaling MyD88 oligomerizationo, Yan Yi Wang, 2019
- Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response., Yan Yi Wang, 2019
- Human Cytomegalovirus DNA Polymerase 1 Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kB-mediated transcription., Yan Yi Wang, 2019
- Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3-and NF-kappa B-Mediated Transcription, Yan Yi Wang, 2019
- Human Cytomegalovirus Protein UL31 Inhiibits DNA Sensing of cGAS to Mediate Immune Evasion, Yan Yi Wang, 2018
- TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis, Yan Yi Wang, 2018
- The Regulation of cGAS, Yan Yi Wang, 2018
- PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria, Yan Yi Wang, 2018
- WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress, Yan Yi Wang, 2018
- Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Imm
Awards
- 16th China Young Female Scientist Award (2020): National Level
- National Ten Thousand Talents Program for Young and Middle-aged Leading Talents in Scientific and Technological Innovation (2019): National Level
- 12th Outstanding Youth of the Chinese Academy of Sciences (2017): Institute Level
- Expert Enjoying Special Government Allowance (2016): National Level
- Ministry of Education Natural Science Award, First Prize (2015): Ministerial Level
- National Natural Science Award, Second Prize (2015): National Level
- National Hundred, Thousand, and Ten Thousand Talent Project 'Outstanding Contribution Young and Middle-aged Expert' (2015): National Level
- Hubei Youth May Fourth Medal (2015): Provincial Level
- National Outstanding Youth Science Fund (2014): National Level
- First Batch of Young Top Talents in the Central Organization Department's Ten Thousand Talents Program (2013): Ministerial Level
- Outstanding Scientific and Technological Worker of Wuhan (2013): Municipal Level
- Wuhan Youth Science and Technology Award (2012): Municipal Level
- Luojia Young Scholar of Wuhan University (2012): Institutional Level
- Chinese Immunology Youth Scholar Award (2010): Other
- Second Prize in Wuhan University Young Teacher Teaching Competition (2010): Institutional Level
- Advanced Individual in Student Work of Wuhan University (2008): Institutional Level
