2002-11--2006-03 PhD: University of Oxford, Duncan School of Pathology
1988-08--1992-06 Bachelor's: Lanzhou University, Department of Biology
2020-03~Present - Institute of Microbiology, Chinese Academy of Sciences - Group Leader
2009-10~2020-03 - Institute of Pathogen Biology, Chinese Academy of Medical Sciences - Group Leader
2009-01~2009-09 - National Institute for Biological Standards and Control, UK - Senior Scientist, Head of Live Attenuated Vaccine Unit
2006-03~2008-12 - University of Oxford, Duncan School of Pathology - Postdoctoral Researcher
2002-11~2006-03 - University of Oxford, Duncan School of Pathology - PhD
2001-11~2006-03 - University of Oxford, Duncan School of Pathology - Research Assistant
2001-04~2001-11 - University of Oxford, Duncan School of Pathology - Visiting Scholar
1992-06~2000-08 - Lanzhou Institute of Biological Products, Ministry of Health - Assistant Engineer
2015: Peking Union Medical College Distinguished Professor
2015: Gates Foundation and Ministry of Science and Technology 'Grand Challenges 2015 Young Scientist' Award
Research
Molecular Mechanisms of Influenza Virus Replication Antiviral Strategies and Vaccine Development Research on Influenza Virus RNA Characteristics, Structure, and Function
Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication, Not mentioned, 2024
Twenty natural amino acid substitution screening at the last residue 121 of influenza A virus NS2 protein reveals the critical role of NS2 in promoting virus genome replication by coordinating with viral polymerase, Not mentioned, 2024
Fine Regulation of Influenza Virus RNA Transcription and Replication by Stoichiometric Changes in Viral NS1 and NS2 Proteins., Not mentioned, 2023
The Hierarchical Sequence Requirements of the H1 SubtypeSpecific Noncoding Regions of Influenza A Virus, Not mentioned, 2022
Anti-inflammatory effects of Chaishi Tuire Granules on influenza A treatment by mediating TRAF6/MAPK14 axis, Not mentioned, 2022
Apolipoprotein E mediates cell resistance to influenza virus infection, Not mentioned, 2022
An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA, Not mentioned, 2022
Synergistic Effect between 3 '-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference, Not mentioned, 2021
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, Not mentioned, 2021
Structural insight into RNA synthesis by influenza D polymerase, Not mentioned, 2019
Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses, Not mentioned, 2019
Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1, Not mentioned, 2019
Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System, Not mentioned, 2017
Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter, Not mentioned, 2017
Generation of an H9N2 avian influenza virus and characterization of its replication properties in different cells, Not mentioned, 2015
Influenza A virus utilizes a suboptimal Kozak sequence to fine-tune virus replication and host response., Not mentioned, 2015
DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity, Not mentioned, 2014
Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein, Not mentioned, 2014
The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity, Not mentioned, 2014
Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus, Not mentioned, 2014
New Insights into the Nonconserved Noncoding Region of the Subtype-Determinant Hemagglutinin and Neuraminidase Segments of Influenza A Viruses, Not mentioned, 2014
A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly, Not mentioned, 2013
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site, Not mentioned, 2009
The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) regulates promoter binding, Not mentioned, 2009
Hsp90 inhibitors reduce influenza virus replication in cell culture, Not mentioned, 2008
Different De Novo Initiation Strategies Are Used by Influenza Virus RNA Polymerase on Its cRNA and Viral RNA Promoters during Viral RNA Replication, Not mentioned, 2006
Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication, Not mentioned, 2006
The role of Ran binding protein 5 (RanBP5) in the nuclear import and assembly of the influenza virus RNA polymerase complex, Not mentioned, 2006
In Vitro Assembly of PB2 with a PB1-PA Dimer Supports a New Model of Assembly of Influenza A Virus Polymerase Subunits into a Functional Trimeric Complex, Not mentioned, 2005
Mutational Analysis of the Influenza Virus cRNA Promoter and Identification of Nucleotides Critical for Replication, Not mentioned, 2004
A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs, Not mentioned, 2003
A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs, Not mentioned, 2002
