Areas of Focus
- Molecular Mechanisms of Influenza Virus Replication
- Antiviral Strategies and Vaccine Development
- Research on Influenza Virus RNA Characteristics, Structure, and Function
Work Experience
- 2020-03~Present - Institute of Microbiology, Chinese Academy of Sciences - Group Leader
- 2009-10~2020-03 - Institute of Pathogen Biology, Chinese Academy of Medical Sciences - Group Leader
- 2009-01~2009-09 - National Institute for Biological Standards and Control, UK - Senior Scientist, Head of Live Attenuated Vaccine Unit
- 2006-03~2008-12 - University of Oxford, Duncan School of Pathology - Postdoctoral Researcher
- 2002-11~2006-03 - University of Oxford, Duncan School of Pathology - PhD
- 2001-11~2006-03 - University of Oxford, Duncan School of Pathology - Research Assistant
- 2001-04~2001-11 - University of Oxford, Duncan School of Pathology - Visiting Scholar
- 1992-06~2000-08 - Lanzhou Institute of Biological Products, Ministry of Health - Assistant Engineer
Academic Background & Achievements
- 2002-11--2006-03 PhD: University of Oxford, Duncan School of Pathology
- 1988-08--1992-06 Bachelor's: Lanzhou University, Department of Biology
Publications
- Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication, Not mentioned, 2024
- Twenty natural amino acid substitution screening at the last residue 121 of influenza A virus NS2 protein reveals the critical role of NS2 in promoting virus genome replication by coordinating with viral polymerase, Not mentioned, 2024
- Fine Regulation of Influenza Virus RNA Transcription and Replication by Stoichiometric Changes in Viral NS1 and NS2 Proteins., Not mentioned, 2023
- The Hierarchical Sequence Requirements of the H1 SubtypeSpecific Noncoding Regions of Influenza A Virus, Not mentioned, 2022
- Anti-inflammatory effects of Chaishi Tuire Granules on influenza A treatment by mediating TRAF6/MAPK14 axis, Not mentioned, 2022
- Apolipoprotein E mediates cell resistance to influenza virus infection, Not mentioned, 2022
- An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA, Not mentioned, 2022
- Synergistic Effect between 3 '-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference, Not mentioned, 2021
- Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, Not mentioned, 2021
- Structural insight into RNA synthesis by influenza D polymerase, Not mentioned, 2019
- Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses, Not mentioned, 2019
- Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1, Not mentioned, 2019
- Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System, Not mentioned, 2017
- Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter, Not mentioned, 2017
- Generation of an H9N2 avian influenza virus and characterization of its replication properties in different cells, Not mentioned, 2015
- Influenza A virus utilizes a suboptimal Kozak sequence to fine-tune virus replication and host response., Not mentioned, 2015
- DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity, Not mentioned, 2014
- Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein, Not mentioned, 2014
- The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity, Not mentioned, 2014
- Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus, Not mentioned, 2014
- New Insights into the Nonconserved Noncoding Region of the Subtype-Determinant Hemagglutinin and Neuraminidase Segments of Influenza A Viruses, Not mentioned, 2014
- A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly, Not mentioned, 2013
- Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site, Not mentioned, 2009
- The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) regulates promoter binding, Not mentioned, 2009
- Hsp90 inhibitors reduce influenza virus replication in cell culture, Not mentioned, 2008
- Different De Novo Initiation Strategies Are Used by Influenza Virus RNA Polymerase on Its cRNA and Viral RNA Promoters during Viral RNA Replication, Not mentioned, 2006
- Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication, Not mentioned, 2006
- The role of Ran binding protein 5 (RanBP5) in the nuclear import and assembly of the influenza virus RNA polymerase complex, Not mentioned, 2006
- In Vitro Assembly of PB2 with a PB1-PA Dimer Supports a New Model of Assembly of Influenza A Virus Polymerase Subunits into a Functional Trimeric Complex, Not mentioned, 2005
- Mutational Analysis of the Influenza Virus cRNA Promoter and Identification of Nucleotides Critical for Replication, Not mentioned, 2004
- A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs, Not mentioned, 2003
- A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs, Not mentioned, 2002
Awards
- 2015: Peking Union Medical College Distinguished Professor
- 2015: Gates Foundation and Ministry of Science and Technology 'Grand Challenges 2015 Young Scientist' Award
