Areas of Focus
- 流感病毒复制分子机制
- 抗病毒策略与疫苗研发
- 流感病毒RNA特征，结构及其功能研究
Work Experience
- 2020-03~现在 - 中国科学院微生物研究所 - 课题组长
- 2009-10~2020-03 - 中国医学科学院病原生物学研究所 - 课题组长
- 2009-01~2009-09 - 英国国家生物制品标准与控制研究院 - 高级科学家，减毒活疫苗室主任
- 2006-03~2008-12 - 英国牛津大学邓肯病理学院 - 博士后
- 2002-11~2006-03 - 英国牛津大学邓肯病理学院 - 博士
- 2001-11~2006-03 - 英国牛津大学邓肯病理学院 - 研究助理
- 2001-04~2001-11 - 英国牛津大学邓肯病理学院 - 访问学者
- 1992-06~2000-08 - 原卫生部兰州生物制品研究所 - 助理工程师
Academic Background & Achievements
- 2002-11--2006-03 博士: 英国牛津大学邓肯病理学院
- 1988-08--1992-06 学士: 兰州大学生物系
Publications
- Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication, 未提及, 2024
- Twenty natural amino acid substitution screening at the last residue 121 of influenza A virus NS2 protein reveals the critical role of NS2 in promoting virus genome replication by coordinating with viral polymerase, 未提及, 2024
- Fine Regulation of Influenza Virus RNA Transcription and Replication by Stoichiometric Changes in Viral NS1 and NS2 Proteins., 未提及, 2023
- The Hierarchical Sequence Requirements of the H1 SubtypeSpecific Noncoding Regions of Influenza A Virus, 未提及, 2022
- Anti-inflammatory effects of Chaishi Tuire Granules on influenza A treatment by mediating TRAF6/MAPK14 axis, 未提及, 2022
- Apolipoprotein E mediates cell resistance to influenza virus infection, 未提及, 2022
- An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA, 未提及, 2022
- Synergistic Effect between 3 '-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference, 未提及, 2021
- Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, 未提及, 2021
- Structural insight into RNA synthesis by influenza D polymerase, 未提及, 2019
- Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses, 未提及, 2019
- Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1, 未提及, 2019
- Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System, 未提及, 2017
- Dual Roles of the Hemagglutinin Segment
Awards
- 2015: 中国医学科学院 北京协和医学院 协和学者特聘教授
- 2015: 盖茨基金会 科技部“大挑战 2015· 青年科学家”奖
