Areas of Focus
- Epigenomics and Bioinformatics of Organ Regeneration
Work Experience
- 2020-12 to Present: Researcher, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- 2014-12 to 2020-11: Postdoctoral Fellow, Johns Hopkins University
Academic Background & Achievements
- 2009-09 to 2014-07: Ph.D. in Bioinformatics, Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2005-09 to 2009-07: Bachelor's degree, Chongqing University
Publications
- DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334, Corresponding Author, 2022
- IReNA: Integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles, Corresponding Author, 2022
- LRLoop: a method to predict feedback loops in cell-cell communication, 5th Author, 2022
- Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1, 6th Author, 2021
- Gene regulatory networks controlling vertebrate retinal regeneration, 2nd Author, 2020
- Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways, 5th Author, 2020
- Investigating cone photoreceptor development using patient-derived NRL null retinal organoids, 3rd Author, 2020
- Comparative transcriptomic and epigenomic analysis identifies regulators of neurogenic competence in retinal Muller glia, 3rd Author, 2018
- Muller cell transcriptional unit to regulate stress induced LIF expression, 4th Author, 2018
- Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina, 5th Author, 2018
- Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes, 4th Author, 2018
- ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration, 1st Author, 2018
- Heterozygous IDH1 R132H created by 'single base editing' inhibits human astroglial cell growth by downregulating YAP, 2nd Author, 2018
- The Prediction of Clinical Outcome in Hepatocellular Carcinoma Based on a Six-Gene Metastasis Signature, Corresponding Author, 2017
- ScaPD: a database for human scaffold proteins, 3rd Author, 2017
- Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes, 1st Author, 2016
- Long Noncoding RNA DANCR Increases Stemness Features of Hepatocellular Carcinoma by Derepression of CTNNB1, 2nd Author, 2016
- Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and IncRNA expression profiles, 2nd Author, 2015
- Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma, 3rd Author, 2014
- Synchronization of cytoplasm and transferred mitochondrial ribosomal protein gene expression in land plants is linked to telo-box motif enrichment, 1st Author, 2011
Awards
- Wilmer Distinguished Postdoctoral Award, First Prize, 2018
