Areas of Focus
- Opioid Receptor Function Research
- Neurobiological Mechanisms of Addiction
- Development of Analgesics and Anti-addiction Drugs
Work Experience
- 2013-06 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
- 2009-09 to 2013-03 - Temple University School of Medicine - Postdoctoral Researcher
- 2005-09 to 2009-06 - Shenyang Pharmaceutical University - PhD in Pharmacology
Academic Background & Achievements
- 2005-09 to 2009-06 - PhD in Pharmacology: Shenyang Pharmaceutical University
Publications
- Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion, 11th Author, 2023
- Changes in mRNA and miRNA expression in the prelimbic cortex related to depression-like syndrome induced by chronic social defeat stress in mice, 11th Author, 2023
- Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, 11th Author, 2022
- Dezocine as a potent analgesic: overview of its pharmacological characterization, 11th Author, 2022
- SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity, 11th Author, 2022
- Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic, 11th Author, 2021
- Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity, 2nd Author, 2021
- Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence, 11th Author, 2021
- Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory, 11th Author, 2021
- Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation, 11th Author, 2020
- Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic, 11th Author, 2020
- Discovery of a Highly Selective and Potent �� Opioid Receptor Agonist from N -Cyclopropylmethyl-7��-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept., 2nd Author, 2019
- Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a k Partial Agonist and mu Partial Agonist., 11th Author, 2018
- ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation, 11th Author, 2018
- 7��-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues, 6th Author, 2018
- Src���dependent phosphorylation of �����opioid receptor at Tyr336 modulates opiate withdrawal, Not mentioned, 2017
- Heteromers of �� opioid and dopamine D 1 receptors modulate opioid���induced locomotor sensitization in a dopamine���independent manner, 8th Author, 2017
- Opioid receptor activation in different brain regions differentially modulate anxiety-related behaviors in mice., Not mentioned, 2016
- The anxiolytic- and anti-depressant-like effects of ATPM-ET, a novel k agonist and m partial agonist, in mice, 11th Author, 2016
- Novel ��-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation, 0th Author, 2015
- Role for engagement of-arrestin2 by the transactivated EGFR in agonist-specific regulation of receptor activation of ERK1/2, 2nd Author, 2015
- Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with �� agonist and �� agonist/antagonist activity, 13th Author, 2014
Awards
- Young Pharmacologist Award of the Chinese Pharmacological Society (2018)
- SA-SIBS Outstanding Young Scientist Award (2018)
- Selected for the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017)
- Selected for the 'Rising Star' Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2016)
