Professor | Wang Yujun | Asia Growth Partners

Name	Wang Yujun
Contact Information	yjwang@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Wang Yujun

Contact Information

yjwang@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2005-09 to 2009-06 - PhD in Pharmacology: Shenyang Pharmaceutical University
Work Experience	2013-06 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher 2009-09 to 2013-03 - Temple University School of Medicine - Postdoctoral Researcher 2005-09 to 2009-06 - Shenyang Pharmaceutical University - PhD in Pharmacology
Awards	Young Pharmacologist Award of the Chinese Pharmacological Society (2018) SA-SIBS Outstanding Young Scientist Award (2018) Selected for the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017) Selected for the 'Rising Star' Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2016)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2005-09 to 2009-06 - PhD in Pharmacology: Shenyang Pharmaceutical University

Work Experience

2013-06 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
2009-09 to 2013-03 - Temple University School of Medicine - Postdoctoral Researcher
2005-09 to 2009-06 - Shenyang Pharmaceutical University - PhD in Pharmacology

Awards

Young Pharmacologist Award of the Chinese Pharmacological Society (2018)
SA-SIBS Outstanding Young Scientist Award (2018)
Selected for the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017)
Selected for the 'Rising Star' Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2016)

Areas of Focus	Opioid Receptor Function Research Neurobiological Mechanisms of Addiction Development of Analgesics and Anti-addiction Drugs
Publications	Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion, 11th Author, 2023 Changes in mRNA and miRNA expression in the prelimbic cortex related to depression-like syndrome induced by chronic social defeat stress in mice, 11th Author, 2023 Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, 11th Author, 2022 Dezocine as a potent analgesic: overview of its pharmacological characterization, 11th Author, 2022 SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity, 11th Author, 2022 Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic, 11th Author, 2021 Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity, 2nd Author, 2021 Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence, 11th Author, 2021 Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory, 11th Author, 2021 Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation, 11th Author, 2020 Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic, 11th Author, 2020 Discovery of a Highly Selective and Potent �� Opioid Receptor Agonist from N -Cyclopropylmethyl-7��-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept., 2nd Author, 2019 Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a k Partial Agonist and mu Partial Agonist., 11th Author, 2018 ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation, 11th Author, 2018 7��-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues, 6th Author, 2018 Src��dependent phosphorylation of ��opioid receptor at Tyr336 modulates opiate withdrawal, Not mentioned, 2017 Heteromers of �� opioid and dopamine D 1 receptors modulate opioid��induced locomotor sensitization in a dopamine��independent manner, 8th Author, 2017 Opioid receptor activation in different brain regions differentially modulate anxiety-related behaviors in mice., Not mentioned, 2016 The anxiolytic- and anti-depressant-like effects of ATPM-ET, a novel k agonist and m partial agonist, in mice, 11th Author, 2016 Novel ��-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation, 0th Author, 2015 Role for engagement of-arrestin2 by the transactivated EGFR in agonist-specific regulation of receptor activation of ERK1/2, 2nd Author, 2015 Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with �� agonist and �� agonist/antagonist activity, 13th Author, 2014

Areas of Focus

Opioid Receptor Function Research
Neurobiological Mechanisms of Addiction
Development of Analgesics and Anti-addiction Drugs

Publications

Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion, 11th Author, 2023
Changes in mRNA and miRNA expression in the prelimbic cortex related to depression-like syndrome induced by chronic social defeat stress in mice, 11th Author, 2023
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, 11th Author, 2022
Dezocine as a potent analgesic: overview of its pharmacological characterization, 11th Author, 2022
SLL-627 Is a Highly Selective and Potent ? Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity, 11th Author, 2022
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic, 11th Author, 2021
Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity, 2nd Author, 2021
Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence, 11th Author, 2021
Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory, 11th Author, 2021
Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation, 11th Author, 2020
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic, 11th Author, 2020
Discovery of a Highly Selective and Potent �� Opioid Receptor Agonist from N -Cyclopropylmethyl-7��-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept., 2nd Author, 2019
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a k Partial Agonist and mu Partial Agonist., 11th Author, 2018
ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation, 11th Author, 2018
7��-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues, 6th Author, 2018
Src��dependent phosphorylation of ��opioid receptor at Tyr336 modulates opiate withdrawal, Not mentioned, 2017
Heteromers of �� opioid and dopamine D 1 receptors modulate opioid��induced locomotor sensitization in a dopamine��independent manner, 8th Author, 2017
Opioid receptor activation in different brain regions differentially modulate anxiety-related behaviors in mice., Not mentioned, 2016
The anxiolytic- and anti-depressant-like effects of ATPM-ET, a novel k agonist and m partial agonist, in mice, 11th Author, 2016
Novel ��-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation, 0th Author, 2015
Role for engagement of-arrestin2 by the transactivated EGFR in agonist-specific regulation of receptor activation of ERK1/2, 2nd Author, 2015
Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with �� agonist and �� agonist/antagonist activity, 13th Author, 2014

Opioid Receptor Function Research Neurobiology Addiction Mechanism Analgesic Drug Development

Jingen Liu - University of Chinese Academy of Sciences

Zhuo Wang - Southern University of Science and Technology

Junli Fan - Wuhan University

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