Areas of Focus
- Gene Engineering Technology
- Epigenetic Modification Technology Development and Application
Work Experience
- 2014-05~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
- 2009-08~2014-01 - Massachusetts Institute of Technology - Postdoctoral Researcher
- 2003-09~2009-07 - University of Washington - PhD
- 2001-09~2003-05 - University of Miami - Master's
- 1997-09~2001-07 - Xiamen University - Bachelor's
Academic Background & Achievements
- 2003-09--2009-07 PhD: University of Washington
- 2001-09--2003-05 Master's: University of Miami
- 1997-09--2001-07 Bachelor's: Xiamen University
Publications
- Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox, 10th Author, 2024
- Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency., 2nd Author, 2024
- Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors, 11th Author, 2023
- Characterisation of X chromosome status of human extended pluripotent stem cells, 2nd Author, 2023
- Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells, 3rd Author, 2022
- Genetically Encoded Double-Stranded DNA-Based Nanostructure Folded by a Covalently Bivalent CRISPR/dCas System, 10th Author, 2022
- Loss of circSRY reduces H2AX level in germ cells and impairs mouse spermatogenesis, 2nd Author, 2022
- Small-molecule compounds boost genome-editing efficiency of cytosine base editor, 13th Author, 2021
- Mutant B2M-HLA-E and B2M-HLA-G fusion proteins protects universal chimeric antigen receptor-modified T cells from allogeneic NK cell-mediated lysis, 8th Author, 2021
- Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors, 16th Author, 2021
- Response to 'Reproducibility of CRISPR Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation', 2nd Author, 2021
- Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation, 9th Author, 2020
- Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway, 7th Author, 2020
- Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development, 16th Author, 2020
- Recent advances of genome editing and related technologies in China, 2nd Author, 2020
- Recent advances in CRISPR research, 3rd Author, 2020
- Engineering T Cells Using CRISPR/Cas9 for Cancer Therapy, 1st Author, 2020
- TGF-beta inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors, 9th Author, 2020
- Gene-edited babies: What went wrong and what could go wrong, 1st Author, 2019
- 5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system, 6th Author, 2019
- 基因编辑技术照亮治癌之路, 2nd Author, 2019
- Bacteria-free minicircle DNA system to generate integration-free CAR-T cells, 7th Author, 2019
- Extended pluripotent stem cells facilitate mouse model generation, 2nd Author, 2019
- In vitro transcribed sgRNA causes cell death by inducing interferon release, 6th Author, 2019
- Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C, 11th Author, 2019
- Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs, 8th Author, 2018
- 5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system, 6th Author, 2018
- 利用CRISPR-Cas9基因编辑技术对CSSL37的YSA基因进行定点编辑, 8th Author, 2018
- 基因编辑技术最新研究进展及在疾病治疗中的应用, 2nd Author, 2018
- Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells, 16th Author, 2018
- Extended pluripotent stem cells facilitate mouse model generation, 2nd Author, 2018
- 基因编辑在T细胞治疗中的应用, 3rd Author, 2018
- Gene Editing in T Cell Therapy, 3rd Author, 2017
- 基础研究的喜悦无与伦比-未来论坛独家专访2017未来科学大奖生命科学奖得主施一公, 1st Author, 2017
- Editing Base in Mouse Model, 1st Author, 2017
- Chapter 15 - Generating Mouse Models Using Zygote Electroporation of Nucleases (ZEN) Technology with High Efficiency and Throughput, 3rd Author, 2017
- CRISPR-Cas9 Mediated LAG-3 Disruption in CAR-T cells, 10th Author, 2017
- Questions about NgAgo (vol 7, pg 913, 2016), 14th Author, 2017
- Temperature Effect on CRISPR-Cas9 Mediated Genome Editing, 5th Author, 2017
- Editing base in mouse model, 1st Author, 2017
- Erratum to: Questions about NgAgo, 14th Author, 2017
- CRISPR-Cas9-Mediated Multiplex Gene Editing in CAR-T Cells, 10th Author, 2017
- Delivery of Cas9 protein into mouse zygotes through a series of electroporation dramatically increased the efficiency of model creation, 10th Author, 2016
- Casilio: A Versatile CRISPR-Cas9-Pumilio Hybrid for Gene Regulation and Genomic Labeling, 8th Author, 2016
- NgAgo: An Exciting New Tool for Genome Editing, 1st Author, 2016
- Questions about NgAgo, 13th Author, 2016
- Molecular Criteria for Defining the Naive Human Pluripotent State, 8th Author, 2016
- CRISPR-Cas9 Application in Mouse Model Creation and Transcription Regulation, 1st Author, 2016
- 基于CRISPR-Cas9新型基因编辑技术研究, 1st Author, 2016
- Generating Mouse Models Using CRISPR/Cas-Mediated Genome Engineering, 8th Author, 2016
- Questions About NgAgo, 14th Author, 2016
- 靶向核酸酶介导基因编辑技术的发展, 2nd Author, 2015
- CRISPR-Cas9-mediated genome editing and guide RNA design, 4th Author, 2015
- Targeting Hepatitis B Virus cccDNA by CRISPR/Cas9 Nuclease Efficiently Inhibits Viral Replication, 3rd Author, 2015
- Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease, 10th Author, 2015
- Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency, 3rd Author, 2014
- Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells, 3rd Author, 2014
- Generating genetically modified mice using CRISPR/Cas-mediated genome engineering, 2nd Author, 2014
- Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease, 9th Author, 2013
- One-Step Generation of Mice Carrying Mut
