Professor | Hongyan Wang | Asia Growth Partners

Name	Hongyan Wang
Contact Information	hongyanwang@sibcb.ac.cn
Language ability	English, Chinese
Province	Shanghai

Name

Hongyan Wang

Contact Information

hongyanwang@sibcb.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09--2006-09 PhD: Imperial College London, UK
Work Experience	2010-01~Present - Shanghai Institute of Biochemistry and Cell Biology - Researcher 2006-09~2010-01 - University of Cambridge, UK - Research Fellow 2001-10~2006-09 - Imperial College London, UK - Research Associate
Awards	CAS Excellent Graduate Student Supervisor Award (2015): Institute Level NSFC Excellent Young Scientist Fund (2014): National Level Shanghai Pujiang Talent Program (2011): Provincial Level British Society of Immunology Travel Grant (2009): Special Award Keystone Meeting Travel Grant (2008): Special Award

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09--2006-09 PhD: Imperial College London, UK

Work Experience

2010-01~Present - Shanghai Institute of Biochemistry and Cell Biology - Researcher
2006-09~2010-01 - University of Cambridge, UK - Research Fellow
2001-10~2006-09 - Imperial College London, UK - Research Associate

Awards

CAS Excellent Graduate Student Supervisor Award (2015): Institute Level
NSFC Excellent Young Scientist Fund (2014): National Level
Shanghai Pujiang Talent Program (2011): Provincial Level
British Society of Immunology Travel Grant (2009): Special Award
Keystone Meeting Travel Grant (2008): Special Award

Areas of Focus	Macrophage and T cell regulation in inflammation-related diseases
Publications	FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination., Ma, Li, Li, Weiyun, Zhang, Yanbo, Qi, Linlin, Zhao, Qi, Li, Na, Lu, Yao, Zhang, Luqing, Zhou, Fei, Wu, Yichun, He, Yongning, Yu, Hongxiu, He, Yulong, Wei, Bin, Wang, Hongyan, 2022 AKT2 reduces IFN beta 1 production to modulate antiviral responses and systemic lupus erythematosus., Zheng, Xin, Xiao, Jun, Jiang, Qi, Zheng, Lingming, Liu, Chang, Dong, Chen, Zheng, Yuxiao, Ni, Peili, Zhang, Chi, Zhang, Fang, Zhong, Ruiyue, Ding, Huihua, Wang, Qiong, Qiu, Ying, Gao, Minxia, Ding, Jianping, Shen, Nan, Wei, Bin, Wang, Hongyan, 2022 Meningeal lymphatic vessels mediate the drainage of virus from the central nervous system and protect against neurotropic virus infection., Wang, Hongyan, 2022 M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery., Zhiqi Li, Jun Xiao, Xiaoyan Xu, Weiyun Li, Ruiyue Zhong, Linlin Qi, Jiehui Chen, Guizhong Cui, Shuang Wang, Yuxiao Zheng, Ying Qiu, Sheng Li, Xin Zhou, Yao Lu, Jiaying Lyu, Bin Zhou, Jiawei Zhou, Naihe Jing, Bin Wei, Jin Hu, Hongyan Wang, 2021 HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis., Fang Zhang, Linlin Qi, Qiuyun Feng, Baokai Zhang, Xiangyue Li, Chang Liu, Weiyun Li, Qiaojie Liu, Dan Yang, Yue Yin, Chao Peng, Han Wu, ZhaoHui Tang, Xi Zhou, Zou Xiang, Zhijiang Zhang, Hongyan Wang, Bin Wei, 2021 Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity., Zhang, Chi, Li, Weiyun, Lei, Xiaobo, Xie, Zhenfei, Qi, Linlin, Wang, Hui, Xiao, Xia, Xiao, Jun, Zheng, Yuxiao, Dong, Chen, Zheng, Xin, Chen, Shiyang, Chen, Jianfeng, Sun, Bing, Qin, Jun, Zhai, Qiwei, Li, Jinsong, Wei, Bin, Wang, Jianwei, Wang, Hongyan, 2021 Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection., Xiao, Jun, Li, Weiyun, Zheng, Xin, Qi, Linlin, Wang, Hui, Zhang, Chi, Wan, Xiaopeng, Zheng, Yuxiao, Zhong, Ruiyue, Zhou, Xin, Lu, Yao, Li, Zhiqi, Qiu, Ying, Liu, Chang, Zhang, Fang, Zhang, Yanbo, Xu, Xiaoyan, Yang, Zhongzhou, Chen, Hualan, Zhai, Qiwei, Wei, Bin, Wang, Hongyan, 2020 The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis., Wang, Qiong, Zhou, Xin, Yang, Long, Zhao, Yongjian, Chew, Zhihuan, Xiao, Jun, Liu, Chang, Zheng, Xin, Zheng, Yuxiao, Shi, Qi, Liang, Qianqian, Wang, Yongjun, Wang, Hongyan, 2020 LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens., Liu, Chang, Xu, Xiaoyan, Han, Lei, Wan, Xiaopeng, Zheng, Lingming, Li, Chunyang, Liao, Zhaohui, Xiao, Jun, Zhong, Ruiyue, Zheng, Xin, Wang, Qiong, Li, Zonghai, Chen, Hualan, Wei, Bin, Wang, Hongyan, 2020 YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis., Zhou, Xin, Li, Weiyun, Wang, Shuang, Zhang, Panli, Wang, Qiong, Xiao, Jun, Zhang, Chi, Zheng, Xin, Xu, Xiaoyan, Xue, Shengjie, Hui, Lijian, Ji, Hongbin, Wei, Bin, Wang, Hongyan, 2019 ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection., Lu, Yao, Qiu, Ying, Chen, Peng, Chang, Haishuang, Guo, Luqiang, Zhang, Fang, Ma, Li, Zhang, Chi, Zheng, Xin, Xiao, Jun, Zhong, Ruiyue, Han, Lei, Xu, Xiaoyan, Zhang, Yanbo, Li, Dangsheng, Zhong, Guisheng, Boyton, Rosemary, Huang, Ying, He, Yongning, Hu, Ronggui, Wei, Bin, Wang, Hongyan, 2019 Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ., Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang, 2018 Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway., Qiong Wang, Xin Zhou, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Yongjun Wang, Hongyan Wang, Qianqian Liang, 2018 TET3 inhibits IFN-I production independent of DNA demethylation., Wang, Hongyan, 2016 The immune adaptor ADAP regulates reciprocal TGF-b1-integrin crosstalk to protect from H5N1 influenza virus infection., Wang, Hongyan, 2015 ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8(+) cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy., Li, Chunyang, Li, Weiyun, Xiao, Jun, Jiao, Shaozhuo, Teng, Fei, Xue, Shengjie, Zhang, Chi, Sheng, Chun, Leng, Qibin, Rudd, Christopher E, Wei, Bin, Wang, Hongyan, 2015 Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro., Wang, Hongyan, 2015 Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection., Huang, Ying, Jiao, Shaozhuo, Tao, Xiaoyan, Tang, Qing, Jiao, Wentao, Xiao, Jun, Xu, Xiaoyan, Zhang, Yanbo, Liang, Guodong, Wang, Hongyan, 2014 Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors., Wei, Bin, Han, Lei, Abbink, Truus E M, Groppelli, Elisabetta, Lim, Daina, Thaker, Youg Raj, Gao, Wei, Zhai, Rongrong, Wang, Jianhua, Lever, Andrew, Jolly, Clare, Wang, Hongyan, Rudd, Christopher E, 2013 Integrin signaling and function in immune cells., Wang, Hongyan, 2012 Integrin signaling and immunopathology., Wang, Hongyan, 2010 SKAP1 is dispensable for chemokine induced T-cell migration., Wang, Hongyan, 2010 T Cell Receptor 'Inside-Out' Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes., Raab, Monika, Wang, Hongyan, Lu, Yuning, Smith, Xin, Wu, Zhonglin, Strebhardt, Klaus, Ladbury, John E, Rudd, Christopher E, 2010 SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility., Wang, Hongyan, Wei, Bin, Bismuth, Georges, Rudd, Christopher E, 2009 Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells., Helga Schneider, Hongyan Wang, Monika Raab, Elke Valk, Xin Smith, Matt Lovatt, Zhonglin Wu, Braudel MaqueiraIglesias, Klaus Strebhardt, Christopher E Rudd, 2008 SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion., Wang, Hongyan, Rudd, Christopher E, 2008 CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase., Silvy da Rocha Dias, Christopher E Rudd, Bin Wei, Hongyan Wang, 2007 Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion., Wang, Hongyan, Liu, Hebin, Lu, Yuning, Lovatt, Matt, Wei, Bin, Rudd, Christopher E, 2007 An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R., Jo, EK, Wang, HY, Rudd, CE, 2005 Positive and negative adaptors in T cell signaling., Wang, Hongyan, 2004 ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation., Wang, Hongyan, 2004

Areas of Focus

Macrophage and T cell regulation in inflammation-related diseases

Publications

FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination., Ma, Li, Li, Weiyun, Zhang, Yanbo, Qi, Linlin, Zhao, Qi, Li, Na, Lu, Yao, Zhang, Luqing, Zhou, Fei, Wu, Yichun, He, Yongning, Yu, Hongxiu, He, Yulong, Wei, Bin, Wang, Hongyan, 2022
AKT2 reduces IFN beta 1 production to modulate antiviral responses and systemic lupus erythematosus., Zheng, Xin, Xiao, Jun, Jiang, Qi, Zheng, Lingming, Liu, Chang, Dong, Chen, Zheng, Yuxiao, Ni, Peili, Zhang, Chi, Zhang, Fang, Zhong, Ruiyue, Ding, Huihua, Wang, Qiong, Qiu, Ying, Gao, Minxia, Ding, Jianping, Shen, Nan, Wei, Bin, Wang, Hongyan, 2022
Meningeal lymphatic vessels mediate the drainage of virus from the central nervous system and protect against neurotropic virus infection., Wang, Hongyan, 2022
M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery., Zhiqi Li, Jun Xiao, Xiaoyan Xu, Weiyun Li, Ruiyue Zhong, Linlin Qi, Jiehui Chen, Guizhong Cui, Shuang Wang, Yuxiao Zheng, Ying Qiu, Sheng Li, Xin Zhou, Yao Lu, Jiaying Lyu, Bin Zhou, Jiawei Zhou, Naihe Jing, Bin Wei, Jin Hu, Hongyan Wang, 2021
HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis., Fang Zhang, Linlin Qi, Qiuyun Feng, Baokai Zhang, Xiangyue Li, Chang Liu, Weiyun Li, Qiaojie Liu, Dan Yang, Yue Yin, Chao Peng, Han Wu, ZhaoHui Tang, Xi Zhou, Zou Xiang, Zhijiang Zhang, Hongyan Wang, Bin Wei, 2021
Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity., Zhang, Chi, Li, Weiyun, Lei, Xiaobo, Xie, Zhenfei, Qi, Linlin, Wang, Hui, Xiao, Xia, Xiao, Jun, Zheng, Yuxiao, Dong, Chen, Zheng, Xin, Chen, Shiyang, Chen, Jianfeng, Sun, Bing, Qin, Jun, Zhai, Qiwei, Li, Jinsong, Wei, Bin, Wang, Jianwei, Wang, Hongyan, 2021
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection., Xiao, Jun, Li, Weiyun, Zheng, Xin, Qi, Linlin, Wang, Hui, Zhang, Chi, Wan, Xiaopeng, Zheng, Yuxiao, Zhong, Ruiyue, Zhou, Xin, Lu, Yao, Li, Zhiqi, Qiu, Ying, Liu, Chang, Zhang, Fang, Zhang, Yanbo, Xu, Xiaoyan, Yang, Zhongzhou, Chen, Hualan, Zhai, Qiwei, Wei, Bin, Wang, Hongyan, 2020
The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis., Wang, Qiong, Zhou, Xin, Yang, Long, Zhao, Yongjian, Chew, Zhihuan, Xiao, Jun, Liu, Chang, Zheng, Xin, Zheng, Yuxiao, Shi, Qi, Liang, Qianqian, Wang, Yongjun, Wang, Hongyan, 2020
LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens., Liu, Chang, Xu, Xiaoyan, Han, Lei, Wan, Xiaopeng, Zheng, Lingming, Li, Chunyang, Liao, Zhaohui, Xiao, Jun, Zhong, Ruiyue, Zheng, Xin, Wang, Qiong, Li, Zonghai, Chen, Hualan, Wei, Bin, Wang, Hongyan, 2020
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis., Zhou, Xin, Li, Weiyun, Wang, Shuang, Zhang, Panli, Wang, Qiong, Xiao, Jun, Zhang, Chi, Zheng, Xin, Xu, Xiaoyan, Xue, Shengjie, Hui, Lijian, Ji, Hongbin, Wei, Bin, Wang, Hongyan, 2019
ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection., Lu, Yao, Qiu, Ying, Chen, Peng, Chang, Haishuang, Guo, Luqiang, Zhang, Fang, Ma, Li, Zhang, Chi, Zheng, Xin, Xiao, Jun, Zhong, Ruiyue, Han, Lei, Xu, Xiaoyan, Zhang, Yanbo, Li, Dangsheng, Zhong, Guisheng, Boyton, Rosemary, Huang, Ying, He, Yongning, Hu, Ronggui, Wei, Bin, Wang, Hongyan, 2019
Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-β-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit p110δ., Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang, 2018
Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway., Qiong Wang, Xin Zhou, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Yongjun Wang, Hongyan Wang, Qianqian Liang, 2018
TET3 inhibits IFN-I production independent of DNA demethylation., Wang, Hongyan, 2016
The immune adaptor ADAP regulates reciprocal TGF-b1-integrin crosstalk to protect from H5N1 influenza virus infection., Wang, Hongyan, 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8(+) cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy., Li, Chunyang, Li, Weiyun, Xiao, Jun, Jiao, Shaozhuo, Teng, Fei, Xue, Shengjie, Zhang, Chi, Sheng, Chun, Leng, Qibin, Rudd, Christopher E, Wei, Bin, Wang, Hongyan, 2015
Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro., Wang, Hongyan, 2015
Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection., Huang, Ying, Jiao, Shaozhuo, Tao, Xiaoyan, Tang, Qing, Jiao, Wentao, Xiao, Jun, Xu, Xiaoyan, Zhang, Yanbo, Liang, Guodong, Wang, Hongyan, 2014
Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors., Wei, Bin, Han, Lei, Abbink, Truus E M, Groppelli, Elisabetta, Lim, Daina, Thaker, Youg Raj, Gao, Wei, Zhai, Rongrong, Wang, Jianhua, Lever, Andrew, Jolly, Clare, Wang, Hongyan, Rudd, Christopher E, 2013
Integrin signaling and function in immune cells., Wang, Hongyan, 2012
Integrin signaling and immunopathology., Wang, Hongyan, 2010
SKAP1 is dispensable for chemokine induced T-cell migration., Wang, Hongyan, 2010
T Cell Receptor 'Inside-Out' Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes., Raab, Monika, Wang, Hongyan, Lu, Yuning, Smith, Xin, Wu, Zhonglin, Strebhardt, Klaus, Ladbury, John E, Rudd, Christopher E, 2010
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility., Wang, Hongyan, Wei, Bin, Bismuth, Georges, Rudd, Christopher E, 2009
Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells., Helga Schneider, Hongyan Wang, Monika Raab, Elke Valk, Xin Smith, Matt Lovatt, Zhonglin Wu, Braudel MaqueiraIglesias, Klaus Strebhardt, Christopher E Rudd, 2008
SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion., Wang, Hongyan, Rudd, Christopher E, 2008
CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase., Silvy da Rocha Dias, Christopher E Rudd, Bin Wei, Hongyan Wang, 2007
Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion., Wang, Hongyan, Liu, Hebin, Lu, Yuning, Lovatt, Matt, Wei, Bin, Rudd, Christopher E, 2007
An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R., Jo, EK, Wang, HY, Rudd, CE, 2005
Positive and negative adaptors in T cell signaling., Wang, Hongyan, 2004
ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation., Wang, Hongyan, 2004

Macrophage T Cell Inflammation Diseases Regulation Mechanism Immunity Cell Biology Research Innovation

Peng Tan - Southern University of Science and Technology

Hui Wang - Wuhan University

Min Liu - Wuhan University

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