Areas of Focus
- Female Gamete Development and In Vitro Regeneration
- Fertilization Mechanism
- Maintenance of Female Fertility
Work Experience
- 2020-08~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher, Research Group Leader
- 2017-01~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
- 2013-01~2016-12 - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2012-07~2012-12 - Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
- 2010-07~2012-06 - Institute of Zoology, Chinese Academy of Sciences - Postdoctoral Researcher
- 2006-06~2008-06 - University of Ottawa - Visiting Researcher
Academic Background & Achievements
- 2006-06--2008-06 Visiting Researcher: University of Ottawa
- 2004-09--2010-06 PhD in Science: Institute of Zoology, Chinese Academy of Sciences
- 2000-09--2004-06 Bachelor's Degree in Science: China Agricultural University
Publications
- A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human, 11th Author, 2023
- Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice, 11th Author, 2023
- PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development, 11th Author, 2022
- Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation, 11th Author, 2022
- Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice., 11th Author, 2022
- Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis, 11th Author, 2022
- PTHRP PROMOTES DEVELOPMENT OF MOUSE PREIMPLANTATION EMBRYOS THROUGH THE AKT/CYCLIN D1 PATHWAY AND NUCLEAR TRANSLOCATION OF HDAC4, 8th Author, 2021
- Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis, 11th Author, 2021
- METTL3-MEDIATED MRNA N-6-METHYLADENOSINE IS REQUIRED FOR OOCYTE AND FOLLICLE DEVELOPMENT IN MICE, 13th Author, 2021
- Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression, 8th Author, 2021
- FBXO34 REGULATES THE G2/M TRANSITION AND ANAPHASE ENTRY IN MEIOTIC OOCYTES, 11th Author, 2021
- SINGLE-CELL RNA SEQUENCING REVEALS SPECIES-SPECIFIC TIME SPANS OF CELL CYCLE TRANSITIONS IN EARLY OOGENESIS, 6th Author, 2021
- EFFECTS OF MITOCHONDRIA-ASSOCIATED CA(2+)TRANSPORTERS SUPPRESSION ON OOCYTE ACTIVATION, 5th Author, 2021
- Single-cell RNA sequencing reveals the landscape of early female germ cell development, 4th Author, 2020
- Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation, 9th Author, 2020
- Protein phosphatase 6 is a key factor regulating spermatogenesis, 11th Author, 2020
- Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development, 11th Author, 2020
- Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte, 7th Author, 2020
- CENP-W regulates kinetochore-microtubule attachment and meiotic progression of mouse oocytes, 5th Author, 2020
- PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome, 11th Author, 2020
- Cell division cycle 23 is required for mouse oocyte meiotic maturation, 11th Author, 2020
- Deletion of Ck2 beta gene causes germ cell development arrest and azoospermia in male mice, 2nd Author, 2020
- RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization, 11th Author, 2020
- Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor, 8th Author, 2020
- Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis), 10th Author, 2020
- Type 1 diabetes affects zona pellucida and genome methylation in oocytes and granulosa cells, 6th Author, 2020
- CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes, 6th Author, 2020
- NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, 9th Author, 2019
- Meiotic chromatid recombination and segregation assessed with human single cell genome sequencing data, 3rd Author, 2019
- Absence of mitochondrial DNA methylation in mouse oocyte maturation, aging and early embryo development, 2nd Author, 2019
- Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice, 4th Author, 2019
- N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse, 7th Author, 2019
- Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation, 11th Author, 2019
- Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, 2nd Author, 2018
- The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis, 7th Author, 2018
- Glucocorticoid exposure affects female fertility by exerting its effect on the uterus but not on the oocyte: lessons from a hypercortisolism mouse model, 4th Author, 2018
- Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect, 5th Author, 2018
- Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption, 11th Author, 2018
- Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, 2nd Author, 2018
- Removal of Mouse Ovary Fat Pad Affects Sex Hormones, Folliculogenesis and Fertility, 7th Author, 2017
- Geminin Deletion in Pre-Meiotic DNA Replication Stage Causes Spermatogenesis Defect and Infertility, 11th Author, 2017
- Transfer of autologous mitochondria from adipose tissue-derived stem cells rescues oocyte quality and infertility in aged mice, 1st Author, 2017
- Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, 4th Author, 2017
- Oocyte-Specific Deletion of furin Leads to Female Infertility by Causing Early Secondary Follicle Arrest in Mice, 11th Author, 2017
- CenpH regulates meiotic G2/M transition by modulating the APC/C-Cdh1-cyclin B1 pathway in oocytes, 4th Author, 2017
- Oocyte-Specific Deletion of N-WASP Does Not Affect Oocyte Polarity, But Causes Failure of Meiosis II Completion, 1st Author, 2016
- Nek11 Regulates Asymmetric Cell Division During Mouse Oocyte Meiotic Maturation, 2nd Author, 2016
- Exposure to Aroclor-1254 Impairs Spindle Assembly During Mouse Oocyte Maturation, 8th Author, 2016
Awards
- National Maternal and Child Health Science and Technology Award (2015): First Prize, Ministerial Level
- National Population and Family Planning Commission Outstanding Scientific and Technological Achievement Award (2011): First Prize, Ministerial Level
