Professor | Yinli Zhang | Asia Growth Partners

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Name	Yinli Zhang
Contact Information	zhangyinli@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Yinli Zhang

Contact Information

zhangyinli@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2020/06 - Present: Zhejiang University School of Medicine, Associate Researcher 2016/08 - 2020/05: Zhejiang University School of Medicine, Assistant Researcher 2011/09 - 2016/06: Ph.D. in Cell Biology, Zhejiang University, Supervisor: Hengyu Fan 2007/09 - 2011/06: Bachelor's in Biotechnology, Shandong Normal University
Work Experience	2020/06 - Present: Zhejiang University School of Medicine, Associate Researcher 2016/08 - 2020/05: Zhejiang University School of Medicine, Assistant Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2020/06 - Present: Zhejiang University School of Medicine, Associate Researcher
2016/08 - 2020/05: Zhejiang University School of Medicine, Assistant Researcher
2011/09 - 2016/06: Ph.D. in Cell Biology, Zhejiang University, Supervisor: Hengyu Fan
2007/09 - 2011/06: Bachelor's in Biotechnology, Shandong Normal University

Work Experience

2020/06 - Present: Zhejiang University School of Medicine, Associate Researcher
2016/08 - 2020/05: Zhejiang University School of Medicine, Assistant Researcher

Areas of Focus	Mechanisms of oocyte maturation and early embryonic development in females Screening and mechanisms of pathogenic genes in female reproductive disorders
Publications	Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation, Jin J, Ren P, Li X, Zhang Y, Yang W, Ma Y, Lai M, Yu C, Zhang S, Zhang YL, 2023 HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes, Zhang YY, Yang W, Zhang Y, Hu Z, Chen Y, Ma Y, Yang A, Shi Z, Zhou H, Ren P, Shi L, Jin J, Rong Y, Tong X, Zhang YL, Zhang S, 2023 Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest, Tong X, Jin J, Hu Z, Zhang Y, Fan HY, Zhang YL, Zhang S, 2022 Biallelic variants in MOS cause large polar body in oocyte and human female infertility, Yin-Li Zhang, Wei Zheng, Peipei Ren, Jiamin Jin, Zhanhong Hu, Qing Liu, Heng-Yu Fan, Fei Gong, Guang-Xiu Lu, Ge Lin, Songying Zhang, Xiaomei Tong, 2022 Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation, Zhang YL, Zheng W, Ren P, Hu H, Tong X, Zhang SP, Li X, Wang H, Jiang JC, Jin J, Yang W, Cao L, He Y, Ma Y, Zhang Y, Gu Y, Hu L, Luo K, Gong F, Lu GX, Lin G, Fan HY, Zhang S, 2021 Lysophosphatidic acid improves oocyte quality during IVM by activating the ERK1/2 pathway in cumulus cells and oocytes, Ma Y, Yang W, Ren P, Li X, Jin J, Dai Y, Pan Y, Jiang L, Fan H, Zhang YL, Zhang S, 2021 Cyclophosphamide exposure causes long-term detrimental effect of oocytes developmental competence through affecting the epigenetic modification and maternal factors’ transcription during oocyte growth, Weijie Yang, Yerong Ma, Jiamin Jin, Peipei Ren, Hanjing Zhou, Shiqian Xu, Yingyi Zhang, Zhanhong Hu, Yan Rong, Yongdong Dai, Yinli Zhang, Songying Zhang, 2021 Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK, Jin J, Ma Y, Tong X, Yang W, Dai Y, Pan Y, Ren P, Liu L, Fan HY, Zhang Y, Zhang S, 2020 ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes, Ma Y, Jin J, Tong X, Yang W, Ren P, Dai Y, Pan Y, Zhang YL, Zhang S, 2020 The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation, Zhang J, Zhang YL, Zhao LW, Pi SB, Zhang SY, Tong C, Fan HY, 2019 Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing, Zhang J, Zhang YL, Zhao LW, Guo JX, Yu JL, Ji SY, Cao LR, Zhang SY, Shen L, Ou XH, Fan HY, 2019 DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development, Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY, 2018 A MAPK Cascade Couples Maternal mRNA Translation and Degradation to Meiotic Cell Cycle Progression in Mouse Oocytes, Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY, 2017 BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes, Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY, 2016 Development and Characterization of a Novel Long-acting Recombinant Follicle Stimulating Hormone Agonist by Fusing Fc to an FSH-β Subunit, Zhang YL, Guo KP, Ji SY, Liu XM, Wang PL, Wu J, Gao L, Jiang TQ, Xu T, Fan HY, 2016 ERK1/2 Activities Are Dispensable for Oocyte Growth but Are Required for Meiotic Maturation and Pronuclear Formation in Mouse, Zhang YL, Liu XM, Ji SY, Sha QQ, Zhang J, Fan HY, 2015 CBP-CITED4 is Required for Luteinizing Hormone-triggered Target Gene Expression during Ovulation, Zhang YL, Xia Y, Yu C, Richards JS, Liu J, Fan HY, 2014 YAP/TEAD Co-Activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells, Yan Xia, Yin-Li Zhang, Chao Yu, Ting Chang, and Heng-Yu Fan, 2014 TOP2B Is Essential for Ovarian Follicles that Are Hypersensitive to Chemotherapeutic Drugs, Zhang YL, Yu C, Ji SY, Li XM, Zhang YP, Zhang D, Zhou DW, Fan HY, 2013 CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins, Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, 2013

Areas of Focus

Mechanisms of oocyte maturation and early embryonic development in females
Screening and mechanisms of pathogenic genes in female reproductive disorders

Publications

Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation, Jin J, Ren P, Li X, Zhang Y, Yang W, Ma Y, Lai M, Yu C, Zhang S, Zhang YL, 2023
HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes, Zhang YY, Yang W, Zhang Y, Hu Z, Chen Y, Ma Y, Yang A, Shi Z, Zhou H, Ren P, Shi L, Jin J, Rong Y, Tong X, Zhang YL, Zhang S, 2023
Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest, Tong X, Jin J, Hu Z, Zhang Y, Fan HY, Zhang YL, Zhang S, 2022
Biallelic variants in MOS cause large polar body in oocyte and human female infertility, Yin-Li Zhang, Wei Zheng, Peipei Ren, Jiamin Jin, Zhanhong Hu, Qing Liu, Heng-Yu Fan, Fei Gong, Guang-Xiu Lu, Ge Lin, Songying Zhang, Xiaomei Tong, 2022
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation, Zhang YL, Zheng W, Ren P, Hu H, Tong X, Zhang SP, Li X, Wang H, Jiang JC, Jin J, Yang W, Cao L, He Y, Ma Y, Zhang Y, Gu Y, Hu L, Luo K, Gong F, Lu GX, Lin G, Fan HY, Zhang S, 2021
Lysophosphatidic acid improves oocyte quality during IVM by activating the ERK1/2 pathway in cumulus cells and oocytes, Ma Y, Yang W, Ren P, Li X, Jin J, Dai Y, Pan Y, Jiang L, Fan H, Zhang YL, Zhang S, 2021
Cyclophosphamide exposure causes long-term detrimental effect of oocytes developmental competence through affecting the epigenetic modification and maternal factors’ transcription during oocyte growth, Weijie Yang, Yerong Ma, Jiamin Jin, Peipei Ren, Hanjing Zhou, Shiqian Xu, Yingyi Zhang, Zhanhong Hu, Yan Rong, Yongdong Dai, Yinli Zhang, Songying Zhang, 2021
Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK, Jin J, Ma Y, Tong X, Yang W, Dai Y, Pan Y, Ren P, Liu L, Fan HY, Zhang Y, Zhang S, 2020
ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes, Ma Y, Jin J, Tong X, Yang W, Ren P, Dai Y, Pan Y, Zhang YL, Zhang S, 2020
The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation, Zhang J, Zhang YL, Zhao LW, Pi SB, Zhang SY, Tong C, Fan HY, 2019
Mammalian nucleolar protein DCAF13 is essential for ovarian follicle maintenance and oocyte growth by mediating rRNA processing, Zhang J, Zhang YL, Zhao LW, Guo JX, Yu JL, Ji SY, Cao LR, Zhang SY, Shen L, Ou XH, Fan HY, 2019
DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development, Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY, 2018
A MAPK Cascade Couples Maternal mRNA Translation and Degradation to Meiotic Cell Cycle Progression in Mouse Oocytes, Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY, 2017
BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes, Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY, 2016
Development and Characterization of a Novel Long-acting Recombinant Follicle Stimulating Hormone Agonist by Fusing Fc to an FSH-β Subunit, Zhang YL, Guo KP, Ji SY, Liu XM, Wang PL, Wu J, Gao L, Jiang TQ, Xu T, Fan HY, 2016
ERK1/2 Activities Are Dispensable for Oocyte Growth but Are Required for Meiotic Maturation and Pronuclear Formation in Mouse, Zhang YL, Liu XM, Ji SY, Sha QQ, Zhang J, Fan HY, 2015
CBP-CITED4 is Required for Luteinizing Hormone-triggered Target Gene Expression during Ovulation, Zhang YL, Xia Y, Yu C, Richards JS, Liu J, Fan HY, 2014
YAP/TEAD Co-Activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells, Yan Xia, Yin-Li Zhang, Chao Yu, Ting Chang, and Heng-Yu Fan, 2014
TOP2B Is Essential for Ovarian Follicles that Are Hypersensitive to Chemotherapeutic Drugs, Zhang YL, Yu C, Ji SY, Li XM, Zhang YP, Zhang D, Zhou DW, Fan HY, 2013
CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins, Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, 2013

Oocyte Maturation Early Embryonic Development Female Reproductive Disorders Pathogenic Genes Gene Screening Molecular Mechanisms Embryo Fertility Genetics Biomedical Research

Pengfei Xu - Zhejiang University

Xian Wang - Zhejiang University

Dan Zhang - Zhejiang University

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