Huaqiang Xu
eric.xu@simm.ac.cn
English, Chinese
Shanghai
University of Chinese Academy of Sciences
Medical School
  • 1994-11--1996-12 Postdoctoral: Massachusetts Institute of Technology
  • 1991-01--1994-10 PhD: University of Texas Southwestern Medical Center
  • 1985-09--1988-12 Master's: Tsinghua University
  • 1980-09--1985-07 Bachelor's: Tsinghua University
  • 2019-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Selected Talent of Shanghai
  • 2013-04~2022-12 - Key Laboratory of Receptor Structure and Function, Chinese Academy of Sciences - Founder, Director
  • 2010-07~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Director of the Center for Drug Target Structure and Function
  • 2010-01~2010-07 - Van Andel Research Institute, USA - Director of the Center for Structural Science and Drug Discovery
  • 2007-03~2009-12 - Van Andel Research Institute, USA - Distinguished PI/Professor
  • 2002-08~2007-03 - Van Andel Research Institute, USA - Senior PI/Professor
  • 2001-08~2002-07 - Glaxo Wellcome Research Institute, USA - Senior Researcher
  • 1999-08~2001-07 - Glaxo Wellcome Research Institute, USA - Associate Researcher
  • 1996-12~1999-07 - Glaxo Wellcome Research Institute, USA - Researcher
  • 1994-11~1996-12 - Massachusetts Institute of Technology, USA - Postdoctoral
  • 1994-11~1996-12 - Massachusetts Institute of Technology, USA - Research Assistant
  • 1991-01~1994-10 - University of Texas Southwestern Medical Center, USA - PhD
  • 1985-09~1988-12 - Tsinghua University, China - Master's
  • 1980-09~1985-07 - Tsinghua University, China - Bachelor's
  • 2024: 'Revealing the molecular mechanism of GPCR kinase recognition and regulation of GPCR biased signal transduction' selected as one of the 'Top Ten Advances in Scientific Innovation' (Basic Research Category) by the Shanghai Branch of the Chinese Academy of Sciences
  • 2023: 'Pearl Leading Talent of Pudong New Area'
  • 2023: 'Elucidating the structure and function of multiple drug targets' selected as one of the 'Top Ten Advances in Scientific Innovation' (Basic Research Category) by the Shanghai Branch of the Chinese Academy of Sciences
  • 2022: 'Magnolia Honor Award' by Shanghai
  • 2022: 'First Prize of the Ninth 'Contribution Award' by the Chinese Federation of Returned Overseas Chinese
  • 2022: 'Excellent Mentor Award' by the Chinese Academy of Sciences
  • 2022: 'Twenty-second Wu Jieping-Paul Janssen Medical and Pharmaceutical Award'
  • 2021: 'Excellent Mentor Award' by the Chinese Academy of Sciences
  • 2021: 'Thirteenth Tan Jiazhen Life Science Achievement Award'
  • 2020: 'Magnolia Memorial Award' by Shanghai
  • 2020: 'Providing structural theoretical basis for new drug development by analyzing protein structure' selected as one of the 'Major Advances in Chinese Medicine' (Pharmacy Department) by the Chinese Academy of Medical Sciences
  • 2019: 'Excellent Mentor Award' by the Chinese Academy of Sciences
  • 2016: 'WuXi AppTec Life Chemistry Outstanding Achievement Award'
  • 2016: 'Hans Neurath Award' by the International Protein Society
  • 2015: 'Overcoming major scientific problems in cell signal transduction' selected as one of the 'Top Ten Scientific Advances' by the Chinese Academy of Sciences
  • 2014: 'Elucidating the signal pathway of strigolactone regulating rice tillering and plant type' selected as one of the 'Top Ten Scientific Advances in China'
  • 2001: 'GSK Outstanding Research Award'
  • 1999: 'GSK Distinguished Research Award'
Structural Biology
Biophysics
  • Molecular recognition of itch-associated neuropeptides by bombesin receptors, Huaqiang Xu, 2023
  • Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376, Huaqiang Xu, 2023
  • AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors, Huaqiang Xu, 2023
  • Structures of the entire human opioid receptor family, Huaqiang Xu, 2023
  • GPCR activation and GRK2 assembly by a biased intracellular agonist, Huaqiang Xu, 2023
  • Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2, Huaqiang Xu, 2022
  • Structural insights into the ligand binding and G(i) coupling of serotonin receptor 5-HT5A, Huaqiang Xu, 2022
  • Structural basis for the tethered peptide activation of adhesion GPCRs, Huaqiang Xu, 2022
  • Hormone- and antibody-mediated activation of the thyrotropin receptor, Huaqiang Xu, 2022
  • Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, Huaqiang Xu, 2022
  • Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19, Huaqiang Xu, 2022
  • Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor, Huaqiang Xu, 2022
  • Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, Huaqiang Xu, 2022
  • Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor, Huaqiang Xu
Gpcr Kinase Signal Transduction Protein Structure Drug Discovery Neurotransmitter Receptors Ligand Binding Cryo-Em Structural Insights Molecular Mechanism

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