Areas of Focus
- Structural Pharmacology
Work Experience
- 2022-01 to Present - Zhongshan Institute for Drug Innovation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
- 2020-10 to 2021-12 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2020-08 to 2020-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2017-07 to 2020-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
- 2006-12 to 2008-12 - Qingdao Garrison, Marine Defense Regiment - Volunteer Soldier
Academic Background & Achievements
- 2011-07 to 2017-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2004-09 to 2011-07 Bachelor's Degree: Soochow University
Publications
- Molecular recognition of itch-associated neuropeptides by bombesin receptors, 11th Author, 2023
- Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84, 11th Author, 2023
- A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 3rd Author, 2022
- Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, 1st Author, 2022
- Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins, 11th Author, 2022
- Molecular recognition of itch-associated neuropeptides by bombesin receptors, 11th Author, 2022
- Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2, 2nd Author, 2021
- Molecular basis for kinin selectivity and activation of the human bradykinin receptors, 11th Author, 2021
- Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin, 1st Author, 2021
- Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, 3rd Author, 2021
- Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir, 1st Author, 2020
- A complex structure of arrestin-2 bound to a G protein-coupled receptor, 1st Author, 2019
- Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, 1st Author, 2018
- 5-HT1BR和拮抗剂及NTSR1和β-arrestin 1功能复合物的结构研究, 1st Author, 2017
Awards
- Shanghai Youth May Fourth Medal (2023): Provincial Level
- 2023 Pudong New Area 'Mingzhu Elite Talent' (2023): Municipal Level
- Shanghai Pharmaceutical Science and Technology Award Youth Talent Award (2022): Provincial Level
- Outstanding Young Scientific Worker (2021): Institute Level
- Outstanding Communist Party Member (2021): Institute Level
- Sanofi 2021 Outstanding Young Scientific Talent (2021): Institute Level
- Shanghai 'Most Beautiful Retired Soldier' Nomination Award (2020): Provincial Level