Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, 20th Author, 2023
Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, 8th Author, 2023
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety, 8th Author, 2023
Discovery, synthesis and mechanism study of 2,3,5-substituted 1,2,4-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2, 13th Author, 2023
Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, 27th Author, 2023
Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches, 11th Author, 2023
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, 25th Author, 2023
Discovery of Polyphenolic Natural Products as SARS-CoV-2 M-pro Inhibitors for COVID-19, 11th Author, 2023
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors, 11th Author, 2023
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial, 7th Author, 2023
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir, 11th Author, 2023
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis, 8th Author, 2022
Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease, 11th Author, 2022
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 9th Author, 2022
Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, 11th Author, 2022
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease, 11th Author, 2022
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, 11th Author, 2022
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy, 7th Author, 2022
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2, 9th Author, 2022
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease, 11th Author, 2022
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination, 11th Author, 2022
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method, 11th Author, 2022
Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection, 11th Author, 2022
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 9th Author, 2021
Design and development of an oral remdesivir derivative W116 against SARS-CoV-2, 9th Author, 2021
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis, 8th Author, 2021
Drug discovery and development targeting the life cycle of SARS-CoV-2, 2nd Author, 2021
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, 11th Author, 2021
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment, 11th Author, 2021
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2, 9th Author, 2021
Recent Progress in Drug Development against COVID-19, 1st Author, 2021
Drug discovery and development targeting the life cycle of SARS-CoV-2, 11th Author, 2021
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation, 11th Author, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, 14th Author, 2021
Keywords
Drug DesignStructure-BasedMolecular DesignAntiviralAnti-InflammatoryNew DrugsDiscoveryResearchPharmaceuticalInnovation
