Areas of Focus
- Structure-based drug design
- Discovery of new antiviral and anti-inflammatory drugs
Work Experience
- 2009-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Group Leader
- 2005-07~Present - Weizmann Institute of Science, Israel - Postdoctoral
- 2004-07~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2001-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Ph.D.
- 1999-09~Present - Department of Chemistry, East China Normal University - Master's
- 1995-09~Present - Department of Chemistry, East China Normal University - Bachelor's
Academic Background & Achievements
- 2005-07 - Postdoctoral: Weizmann Institute of Science, Israel
- 2001-09 - Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1999-09 - Master's: Department of Chemistry, East China Normal University
- 1995-09 - Bachelor's: Department of Chemistry, East China Normal University
Publications
- Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2, 7th Author, 2024
- Structure-based development of potent and selective type-II kinase inhibitors of RIPK1, 13th Author, 2024
- Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3, 8th Author, 2024
- Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers, 8th Author, 2023
- Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, 20th Author, 2023
- Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay, 0th Author, 2023
- Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors, 9th Author, 2023
- Structure-based design of potent peptidomimetic inhibitors covalently targeting SARS-CoV-2 papain-like protease, 11th Author, 2023
- Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, 20th Author, 2023
- Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, 8th Author, 2023
- Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety, 8th Author, 2023
- Discovery, synthesis and mechanism study of 2,3,5-substituted 1,2,4-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2, 13th Author, 2023
- Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, 27th Author, 2023
- Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches, 11th Author, 2023
- High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, 25th Author, 2023
- Discovery of Polyphenolic Natural Products as SARS-CoV-2 M-pro Inhibitors for COVID-19, 11th Author, 2023
- Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors, 11th Author, 2023
- Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial, 7th Author, 2023
- Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir, 11th Author, 2023
- Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis, 8th Author, 2022
- Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease, 11th Author, 2022
- A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 9th Author, 2022
- Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, 11th Author, 2022
- Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease, 11th Author, 2022
- Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, 11th Author, 2022
- Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy, 7th Author, 2022
- In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2, 9th Author, 2022
- In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease, 11th Author, 2022
- Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination, 11th Author, 2022
- Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method, 11th Author, 2022
- Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection, 11th Author, 2022
- A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 9th Author, 2021
- Design and development of an oral remdesivir derivative W116 against SARS-CoV-2, 9th Author, 2021
- Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis, 8th Author, 2021
- Drug discovery and development targeting the life cycle of SARS-CoV-2, 2nd Author, 2021
- Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, 11th Author, 2021
- Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment, 11th Author, 2021
- Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2, 9th Author, 2021
- Recent Progress in Drug Development against COVID-19, 1st Author, 2021
- Drug discovery and development targeting the life cycle of SARS-CoV-2, 11th Author, 2021
- Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation, 11th Author, 2021
- Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, 14th Author, 2021
Awards
- China Young Female Scientist Award (2022): National Level
- Shulan Medical Youth Award (2020): Other
- WuXi AppTec Life Chemistry Research Award (2020): Other
- Outstanding Mentor Award of the Chinese Academy of Sciences (2020): Institute Level
- Shanghai 'Science and Technology System Craftsman' (2020): Provincial Level
- National Hundred, Thousand, and Ten Thousand Talent Project 'Outstanding Contribution Young and Middle-aged Expert' (2020): National Level
- CAS-Novo Nordisk Great Wall Professor Award (2009): Ministerial Level
- National Excellent Doctoral Dissertation (2006): National Level
