Areas of Focus
- Metabolic Disease Pharmacology (Liver Diseases)
- Clinical Chinese Medicine
Work Experience
- 2019-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
- 2013-10 to 2018-10 - National Institutes of Health, USA - Postdoctoral Fellow
- 2013-07 to 2013-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2008-09 to 2013-06 - University of Chinese Academy of Sciences - PhD Student
- 2004-09 to 2008-06 - Zhejiang University - Bachelor's Student
Academic Background & Achievements
- 2008-09 to 2013-06 PhD: University of Chinese Academy of Sciences
- 2004-09 to 2008-06 Bachelor's: Zhejiang University
Publications
- Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism, Cen Xie, 2024
- Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism, Cen Xie, 2023
- Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPAR nucleus-cytoplasm shuttling, Cen Xie, 2023
- Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders, Cen Xie, 2022
- Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation, Cen Xie, 2022
- Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease, Cen Xie, 2022
- Glycine muricholic acid antagonizes the intestinal farnesoid X receptor ceramide axis and ameliorates NASH in mice, Cen Xie, 2022
- Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis, Cen Xie, 2022
- Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction, Cen Xie, 2022
- Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal, Cen Xie, 2022
- Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists, Cen Xie, 2022
- Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism, Cen Xie, 2021
- Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota, Cen Xie, 2021
- Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer, Cen Xie, 2021
- Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila, Cen Xie, 2021
- Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity, Cen Xie, 2021
- Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients, Cen Xie, 2021
- Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma, Cen Xie, 2021
- Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism, Cen Xie, 2021
- An Integrated LC-MS/MS Strategy for Quantifying the Oxidative-Redox Metabolome in Multiple Biological Samples, Cen Xie, 2020
- Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice, Cen Xie, 2020
- Hepatocyte peroxisome proliferator-activated receptor regulates bile acid synthesis and transport, Cen Xie, 2019
- Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport, Cen Xie, 2019
- Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes, Cen Xie, 2015
- Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms, Cen Xie, 2015
- Effects of Renal Impairment on the Pharmacokinetics of Morinidazole: Uptake Transporter-Mediated Renal Clearance of the Conjugated Metabolites, Cen Xie, 2014
- Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1, Cen Xie, 2014
- Analysis of Perphenazine Metabolites in Human Bile, Cen Xie, 2014
- EFFECT OF RENAL IMPAIRMENT ON THE PHARMACOKINETICS OF MORINIDAZOLE: ALTERED UPTAKE TRANSPORTER-MEDIATED RENAL CLEARANCE?, Cen Xie, 2014
- Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation, Cen Xie, 2014
- High-Resolution Mass Spectrometry: An Ideal Analytical Tool for Drug Metabolism Studies, Cen Xie, 2013
- High-Resolution Mass Spectrometry: An Ideal Premier Analytical Tool for Drug Metabolism Studies, Cen Xie, 2013
- Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation, Cen Xie, 2013
- Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis, Cen Xie, 2013
- Crystal structures of two phytohormone signal-transducing KAI2 and strigolactone-signaling DWARF14, Cen Xie, 2013
- Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans, Cen Xie, 2013
- Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, Cen Xie, 2013
- A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization, Cen Xie, 2013
- Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients, Cen Xie, 2013
- 阿帕替尼在人体内的代谢、排泄和药动学研究, Cen Xie, 2012
- Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations, Cen Xie, 2012
- Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9, Cen Xie, 2012
- Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS, Cen Xie, 2012
- 鉴定大鼠注射绿原酸后体内的代谢产物, Cen Xie, 2011
- Investigation of Isomeric Transformations of Chlorogenic Acid in Buffers and Biological Matrixes by Ultraperformance Liquid Chromatography Coupled with Hybrid Quadrupole/Ion Mobility/Orthogonal Acceleration Time-of-Flight Mass Spectrometry, Cen Xie, 2011
- UPLC/Q-TOFMS法研究吗啉硝唑人体内外代谢, Cen Xie, 2011
- UPLC/Q-TOFMS法检测和鉴定阿帕替尼在肿瘤患者血浆和尿中代谢产物, Cen Xie, 2011
- 液相色谱-串联质谱法检测
Awards
- Shanghai Youth Science and Technology Star A (Class), Provincial Level, 2020
