2008-09 to 2013-06 PhD: University of Chinese Academy of Sciences
2004-09 to 2008-06 Bachelor's: Zhejiang University
2019-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
2013-10 to 2018-10 - National Institutes of Health, USA - Postdoctoral Fellow
2013-07 to 2013-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
2008-09 to 2013-06 - University of Chinese Academy of Sciences - PhD Student
2004-09 to 2008-06 - Zhejiang University - Bachelor's Student
Shanghai Youth Science and Technology Star A (Class), Provincial Level, 2020
Research
Metabolic Disease Pharmacology (Liver Diseases) Clinical Chinese Medicine
Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism, Cen Xie, 2024
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism, Cen Xie, 2023
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease, Cen Xie, 2022
Glycine muricholic acid antagonizes the intestinal farnesoid X receptor ceramide axis and ameliorates NASH in mice, Cen Xie, 2022
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis, Cen Xie, 2022
Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction, Cen Xie, 2022
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal, Cen Xie, 2022
Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists, Cen Xie, 2022
Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism, Cen Xie, 2021
Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota, Cen Xie, 2021
Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer, Cen Xie, 2021
Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila, Cen Xie, 2021
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity, Cen Xie, 2021
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients, Cen Xie, 2021
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma, Cen Xie, 2021
Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism, Cen Xie, 2021
An Integrated LC-MS/MS Strategy for Quantifying the Oxidative-Redox Metabolome in Multiple Biological Samples, Cen Xie, 2020
Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice, Cen Xie, 2020
Hepatocyte peroxisome proliferator-activated receptor regulates bile acid synthesis and transport, Cen Xie, 2019
Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport, Cen Xie, 2019
Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes, Cen Xie, 2015
Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms, Cen Xie, 2015
Effects of Renal Impairment on the Pharmacokinetics of Morinidazole: Uptake Transporter-Mediated Renal Clearance of the Conjugated Metabolites, Cen Xie, 2014
Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1, Cen Xie, 2014
Analysis of Perphenazine Metabolites in Human Bile, Cen Xie, 2014
EFFECT OF RENAL IMPAIRMENT ON THE PHARMACOKINETICS OF MORINIDAZOLE: ALTERED UPTAKE TRANSPORTER-MEDIATED RENAL CLEARANCE?, Cen Xie, 2014
Metabolism and Pharmacokinetics of Allitinib in Cancer Patients: The Roles of Cytochrome P450s and Epoxide Hydrolase in its Biotransformation, Cen Xie, 2014
High-Resolution Mass Spectrometry: An Ideal Analytical Tool for Drug Metabolism Studies, Cen Xie, 2013
High-Resolution Mass Spectrometry: An Ideal Premier Analytical Tool for Drug Metabolism Studies, Cen Xie, 2013
Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation, Cen Xie, 2013
Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis, Cen Xie, 2013
Crystal structures of two phytohormone signal-transducing KAI2 and strigolactone-signaling DWARF14, Cen Xie, 2013
Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans, Cen Xie, 2013
Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, Cen Xie, 2013
A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization, Cen Xie, 2013
Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients, Cen Xie, 2013
阿帕替尼在人体内的代谢、排泄和药动学研究, Cen Xie, 2012
Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations, Cen Xie, 2012
Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9, Cen Xie, 2012
Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS, Cen Xie, 2012
鉴定大鼠注射绿原酸后体内的代谢产物, Cen Xie, 2011
Investigation of Isomeric Transformations of Chlorogenic Acid in Buffers and Biological Matrixes by Ultraperformance Liquid Chromatography Coupled with Hybrid Quadrupole/Ion Mobility/Orthogonal Acceleration Time-of-Flight Mass Spectrometry, Cen Xie, 2011
Area of Focus
Drug Development | Formulations | Lipid Carriers | Injectables | Traditional Medicine | Chinese Medicine | Pharmaceuticals | Nanomedicine | Therapeutics | Bioavailability
Area of Focus
Drug Design | Pharmacology | Traditional Medicine | Chinese Medicine | Research | Development | Innovation | Therapeutics | Bioinformatics | Chemistry
